The objective of this document was to analyze how the design of a didactic unit, in which the didactic transposition is implemented, is applied as a strategy for teaching chemistry in 9th grade students of the Andrés Rodríguez de Sahagún Educational Institution (Córdoba), Where there is a situation of low academic performance and the achievements proposed for the advancement of the educational training process are not being exceeded. Taking as a reference the theory of Yves Chevallard (1991), from wise knowledge to taught knowledge. Considering the development and implementation of the objectives worked, a qualitative approach is used, with a descriptive method using semi-structured interviews where the required information is obtained. The final result is the assessment and relevance of the chemistry teaching unit with the implementation of the didactic transposition giving priority to DBAs and EBCs allowing a closer approach to learning and teaching chemistry in grade 9. For this purpose, a series of phases or stages that allowed determining a process as appropriate as possible to promote meaningful learning of the subject in question.