Frequency of monoclonal B-cell lymphocytosis in relatives of patients with chronic lymphocytic leukemia
Artículo de revista
2016-05-04
Introduction: monoclonal B-cell lymphocytosis is a symptom free
condition characterized by the circulation of small clonal population
of B lymphocytes in peripheral blood (less than 5x109/L) expressing
an immunophenotype similar to chronic lymphocytic leukemia.
Different studies based on big hospital series have manifested a higher
risk in subjects with monoclonal B-cell lymphocytosis to progress to a
chronic lymphocytic leukemia. The behavior of this hematologic entity
is unknown therefore its frequency in sporadic chronic lymphocytic
leukemia patient relatives was determined.
Methods: transversal descriptive study, 8 color flow cytometry was
performed using two of the tubes of the Euro Flow recommended panel,
with modifications, for the diagnose of chronic lymphoproliferative
disorders of B lymphocytes; besides, a fluorescence in situ hybridization
was performed. univariate and bivariate analyses of the information
were performed.
Results: monoclonal B-cell lymphocytosis frequency found in 51
analyzed relatives was 2%, it was a female participant, 59 years old,
with a total leukocyte count of 7.7x109/L and a B lymphocyte count of
0.124x109/L; from these, 0.04x109/L were clonal cells with restrictions
of the kappa light chain. Rearrangements of the IGH gene (14q32)
were found.
Conclusion: monoclonal B-cell lymphocytosis was detected in one
relative of a patient with sporadic chronic lymphocytic leukemia in a
frequency similar to the one reported in general population.
1657-9534
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