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Frequency of monoclonal B-cell lymphocytosis in relatives of patients with chronic lymphocytic leukemia

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dc.contributor.authorVILLEGAS, ROSSANAspa
dc.contributor.authorFRANCO, CATALINAspa
dc.contributor.authorRENDÓN, JAVIERspa
dc.contributor.authorTORRES, JOSÉspa
dc.contributor.authorJARAMILLO, PATRICIAspa
dc.date.accessioned2018-03-05T20:43:56Zspa
dc.date.available2018-03-05T20:43:56Zspa
dc.date.issued2016-05-04spa
dc.description.abstractIntroduction: monoclonal B-cell lymphocytosis is a symptom free condition characterized by the circulation of small clonal population of B lymphocytes in peripheral blood (less than 5x109/L) expressing an immunophenotype similar to chronic lymphocytic leukemia. Different studies based on big hospital series have manifested a higher risk in subjects with monoclonal B-cell lymphocytosis to progress to a chronic lymphocytic leukemia. The behavior of this hematologic entity is unknown therefore its frequency in sporadic chronic lymphocytic leukemia patient relatives was determined. Methods: transversal descriptive study, 8 color flow cytometry was performed using two of the tubes of the Euro Flow recommended panel, with modifications, for the diagnose of chronic lymphoproliferative disorders of B lymphocytes; besides, a fluorescence in situ hybridization was performed. univariate and bivariate analyses of the information were performed. Results: monoclonal B-cell lymphocytosis frequency found in 51 analyzed relatives was 2%, it was a female participant, 59 years old, with a total leukocyte count of 7.7x109/L and a B lymphocyte count of 0.124x109/L; from these, 0.04x109/L were clonal cells with restrictions of the kappa light chain. Rearrangements of the IGH gene (14q32) were found. Conclusion: monoclonal B-cell lymphocytosis was detected in one relative of a patient with sporadic chronic lymphocytic leukemia in a frequency similar to the one reported in general population.spa
dc.identifier.citationVillegas GR, Franco AC, Rendón HJ, Torres HJD, Jaramillo APE. Frequency of monoclonal B-cell lymphocytosis in relatives of patients with chronic lymphocytic leukemia. Colomb Med (Cali). 2016; 47(2): 81-6.spa
dc.identifier.issn1657-9534spa
dc.identifier.urihttps://repositorio.unicordoba.edu.co/handle/ucordoba/618spa
dc.language.isospaspa
dc.rightsCopyright Universidad de Córdoba, 2016spa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.creativecommonsAtribución 4.0 Internacional (CC BY 4.0)spa
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/spa
dc.subjectMonoclonal B-cell lymphocytosis, chronic lymphocytic leukemia, B cells, flow cytometryspa
dc.titleFrequency of monoclonal B-cell lymphocytosis in relatives of patients with chronic lymphocytic leukemiaspa
dc.title.alternativeFrecuencia de linfocitosis monoclonal de células B en familiares de pacientes con leucemia linfoide crónicaeng
dc.typeArtículo de revistaspa
dc.type.coarhttp://purl.org/coar/resource_type/c_6501spa
dc.type.contentTextspa
dc.type.driverinfo:eu-repo/semantics/articlespa
dc.type.redcolhttps://purl.org/redcol/resource_type/ARTspa
dc.type.versioninfo:eu-repo/semantics/publishedVersionspa
dspace.entity.typePublication
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2spa
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa
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