Dinámica clínica, sociodemográfica y espacial de la infección por SARS-COV-2 en el departamento de Córdoba

Abstract

The serological evaluation of SARS-CoV-2 is an alternative that allows knowing the prevalence and dynamics of this infection in populations. Aim. To determine the clinical and socio-demographic dynamics of SARS-CoV-2 infection in a region of the Colombian Caribbean. Methods. Between July and November 2020, a cross-sectional observational study was carried out. The work was carried out in Córdoba, located in the northeast of Colombia in the Caribbean area. Eight municipalities with the largest population were chosen, and 2,564 blood samples were taken. The commercial ELISA was used with the recombinant protein antigen N of SARS-CoV-2. The people included in the study were asked for sociodemographic and clinical data related to pulmonary and extra-pulmonary manifestation of this disease, which were analyzed by statistical methods. Results. A seroposivity of 40.8% was obtained for SARS-CoV-2 in the Cordoba region of the Colombian Caribbean. In the bivariate analysis, no differences were observed in seropositivity against SARS-CoV-2 about gender or age range (P> 0.05). Higher seropositivity was found in low socioeconomic status and symptomatic patients (P <0.0001). 30.7% of the asymptomatic patients were seropositive for SARS-CoV-2, which would be linked to the spread of this infection. In the multivariate analysis, seroconversion was related to poverty and clinical manifestations such as anosmia and ageusia (P <0.05). Conclusions. The high seropositivity in the department of Córdoba would be related to a possible community immunity. Seropositivity would be related to clinical manifestations such as anosmia and ageusia. In addition, the association between seropositivity and socioeconomic level suggests an appropriate context for the transmission of the virus, this being determined by informal economic activities in low-income groups.