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dc.contributor.advisorAngulo Ortiz, Alberto
dc.contributor.authorFuentes Medina, Leandro Luis
dc.date.accessioned2021-01-20T17:57:09Z
dc.date.available2021-01-20T17:57:09Z
dc.date.issued2020-12-19
dc.identifier.urihttps://repositorio.unicordoba.edu.co/handle/ucordoba/3894
dc.description.abstractEl género Duguetia abarca alrededor de 100 especies y es uno de los más abundantes de la familia Annonaceae. En numerosos estudios se informan sobre el uso tradicional de algunas especies de este género como alternativas medicinales para el tratamiento de diferentes problemas de salud por parte de los habitantes de diferentes regiones tropicales del mundo en las cuales se distribuyen estas plantas. En el presente trabajo se realizó la recolección de todos los componentes químicos que forman parte de las especies del género Duguetia estudiadas hasta la actualidad, clasificándolos en alcaloides, flavonoides, compuestos aromáticos, terpenos y lignanos; se presentan las fórmulas estucturales y las actividades biológicas de los metabolitos que fueron mayoritarios en las especies que fueron objeto de estudio, y se mencionan en última instancia algunos de los usos populares que se les ha dado a varias de ellas. La metodología llevada a cabo para la realización de esta monografía consistió en la búsqueda y clasificación de material bibliográfico basado en información química del género Duguetia. Encontrando así, finalmente, un total de 27 especies de Duguetia referencias con estudio químico, así como también la bioactividad de sus principales constituyentes y los aceites esenciales extraídos de algunas de estas especies, dentro de las cuales se destacan la actividad citotóxica, antiplasmodial, antioxidante, insecticida, antinociceptiva, anticorrosiva, antimicrobiana, antisincitio, enzimática, larvicida y antiinflamatoria. Concluyendo conforme a estos resultados, la importancia de seguir explorando químicamente las especies del género Duguetia para la identificación de sustancias prometedoras para el desarrollo de fármacos y formulaciones comerciales que contribuyan al área medicinal, terapéutica y agronómica.spa
dc.description.tableofcontentsI. RESUMEN ................................................................................................... 1spa
dc.description.tableofcontentsII. INTRODUCCIÓN ......................................................................................... 2spa
dc.description.tableofcontentsIII. OBJETIVOS ................................................................................................ 4spa
dc.description.tableofcontentsIII.1. OBJETIVO GENERAL ..................................................................................... 4spa
dc.description.tableofcontentsIII.2. OBJETIVOS ESPECÍFICOS ............................................................................ 4spa
dc.description.tableofcontentsIV. PLANTEAMIENTO DE PROBLEMA........................................................... 5spa
dc.description.tableofcontentsV. JUSTIFICACIÓN DEL PROBLEMA ............................................................ 6spa
dc.description.tableofcontentsVI. MARCO TEÓRICO .........................................................................7spa
dc.description.tableofcontentsVI.1. LA FAMILIA ANNONACEAE ........................................................................... 7spa
dc.description.tableofcontentsVI.1.1. CARACTERÍSTICAS BOTÁNICAS ..................................7spa
dc.description.tableofcontentsVI.1.2. DISTRIBUCIÓN Y ORIGEN ................................................7spa
dc.description.tableofcontentsVI.1.3. USOS E IMPORTANCIA COMERCIAL ............................................ 9spa
dc.description.tableofcontentsVI.1.4. FITOQUÍMICA DE LAS ANNONACEAE ........................................ 11spa
dc.description.tableofcontentsVII. GÉNERO Duguetia ....................................................................17spa
dc.description.tableofcontentsVII.1. DISTRIBUCIÓN ........................................................................17spa
dc.description.tableofcontentsVII.2. DISTRIBUCIÓN DEL GÉNERO Duguetia EN COLOMBIA .......................... 17spa
dc.description.tableofcontentsVII.3. DESCRIPCIÓN BOTÁNICA DE LAS ESPECIES DEL GÉNERO Duguetia ...................................................18spa
dc.description.tableofcontentsVIII. ESTUDIO QUÍMICO DEL GÉNERO DUGUETIA ...................................... 18spa
dc.description.tableofcontentsVIII.1. ALCALOIDES ...........................................................................19spa
dc.description.tableofcontentsVIII.1.1. Benciltetrahidroisoquinolínas ........................................................ 19spa
dc.description.tableofcontentsVIII.1.2. Bisbenciltetrahidroisoquinolínas ................................................... 19spa
dc.description.tableofcontentsVIII.1.3. Berberinas y Protoberberinas ....................................................... 19spa
dc.description.tableofcontentsVIII.1.4. Morfinandienona ........................................................................... 21spa
dc.description.tableofcontentsVIII.1.5. Aporfinoides.................................................................................. 22spa
dc.description.tableofcontentsVIII.1.6. Alcaloides diversos relacionados con aporfinoides y berbinoides 28spa
dc.description.tableofcontentsVIII.2. FLAVONOIDES ........................................................................................... 34spa
dc.description.tableofcontentsVIII.3. COMPUESTOS AROMÁTICOS .................................................................. 36spa
dc.description.tableofcontentsVIII.4. TERPENOS .....................................................37spa
dc.description.tableofcontentsVIII.5. LIGNANOS ...............................................................42spa
dc.description.tableofcontentsVIII.6. DERIVADOS DE ÁCIDOS GRASOS ........................................................... 43spa
dc.description.tableofcontentsVIII.7. OTROS COMPUESTOS AISLADOS ........................................................... 44spa
dc.description.tableofcontentsIX. FARMACOLOGÍA Y USOS TRADICIONALES DE LAS ESPECIES DEL GÉNERO Duguetia ......................................................................................... 44spa
dc.description.tableofcontentsX. CONCLUSIONES ...................................................................................... 60spa
dc.description.tableofcontentsXI. BIBLIOGRAFÍA ......................................................................................... 62spa
dc.format.mimetypeapplication/pdfspa
dc.language.isospaspa
dc.rightsCopyright Universidad de Córdoba, 2020spa
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/spa
dc.titleQuímica del género Duguetia (Annonaceae)spa
dc.typeTrabajo de grado - Pregradospa
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dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.creativecommonsAtribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)spa
dc.subject.proposalDuguetiaspa
dc.subject.proposalAnnonaceaespa
dc.subject.proposalComponentes químicosspa
dc.subject.proposalFármacosspa
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dc.subject.keywordsDuguetiaspa
dc.subject.keywordsAnnonaceaespa
dc.subject.keywordsChemical componentsspa
dc.subject.keywordsDrugsspa
dc.description.degreelevelPregradospa
dc.description.degreenameQuímico(a)spa
dc.publisher.facultyFacultad de Ciencias Básicasspa
dc.publisher.placeMontería, Córdoba, Colombiaspa
dc.publisher.programQuímicaspa
dc.type.contentTextspa
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