Publicación:
Estudio sobre Coxiella burnetii en Córdoba: genotipificación y distribución espacial en rumiantes domésticos y humanos

Vista sencilla de ítem
dc.audience
dc.contributor.advisorMáttar Velilla, Salim
dc.contributor.advisorCalderon Rangel, Alfonso
dc.contributor.advisorGonzález Tous, Marco
dc.contributor.advisorOteo Revuelta, José Antonio
dc.contributor.advisorSánchez Lerma, Liliana
dc.contributor.authorContreras Cogollo, Verónica
dc.contributor.juryRODRÍGUEZ, VIRGINIA
dc.contributor.jurySerrano Coll, Héctor
dc.contributor.juryPalomar Urbina, Ana María
dc.date.accessioned2025-07-22T13:44:47Z
dc.date.available2026-07-18
dc.date.available2025-07-22T13:44:47Z
dc.date.issued2025-07-22
dc.description.abstractCoxiella burnetii es el agente causal de la fiebre Q, una zoonosis altamente infecciosa catalogada como una de las trece zoonosis de mayor importancia a nivel mundial. Objetivo. Caracterizar Coxiella burnetii en rumiantes domésticos y humanos en el departamento de Córdoba. Metodología. Entre noviembre de 2021 y noviembre de 2024, se realizó un estudio descriptivo, de corte transversal. Con base en un muestreo no probabilístico, se incluyeron 38 fincas ganaderas, 2 asociaciones productivas bovinas y 24 fincas de ovinos de 17 municipios del departamento de Córdoba, distribuidos en las zonas agroecológicas: Alto, Medio y Bajo Sinú, Sabanas y Costa. Se tomaron muestras de leche bovina de tanques de enfriamiento y de ordeño (n=142), hisopados vaginales de bovinos (n=564) y ovinos (n=171). Se registraron las características del manejo productivo del ganado y los puntos de georeferenciación (GPS) de las fincas. Por otro lado, se evaluaron pacientes que ingresaron al hospital San Jerónimo de Montería con síntomas compatibles de un síndrome febril agudo indiferenciado, neumonía atípica adquirida en comunidad con cultivo negativo para gérmenes comunes y pacientes con diagnóstico presuntivo de endocarditis, miocarditis o pericarditis. De 37 pacientes se recolectaron muestras de sangre con EDTA, suero, líquido pleural y secreción bronquial, e información clínico-epidemiológica. El consentimiento informado se obtuvo teniendo en cuenta las normas éticas de la declaración de Helsinki y el Ministerio de Salud. Los sueros se analizaron mediante IFI para detección de anticuerpos IgG contra C. burnetii (fases I y II). Las muestras de humanos y animales se analizaron por qPCR para la detección del gen IS1111 de C. burnetii. Algunas muestras positivas (qPCR) seleccionadas se analizaron por PCR anidada (gen rpoB). Los genotipos de C. burnetii fueron determinados mediante Tipificación de Secuencias Multiespaciadoras (MST) y se realizó un análisis filogenético. Las áreas de riesgo potencial de infección a humanos fueron caracterizadas mediante análisis de distribución espacial de fincas infectadas utilizando software ArcGIS. Las variables estudiadas y la frecuencia de infección fueron analizadas mediante estadística descriptiva, test de Chi cuadrado, Odds ratio, análisis multivariado de correspondencia múltiple y modelos ajustados de regresión logística (Lasso y Ridge). Resultados. Se detectó ADN de C. burnetii en muestras de leche (9,8%) e hisopados vaginales (1,1%) de bovinos. El 12,5% de fincas bovinas del departamento de Córdoba se encontraron infectadas con C. burnetii. No se encontró infección en ovinos. El ADN detectado reveló un 100% de identidad con el gen rpoB de cepas de C. burnetii descritas a nivel mundial. El genotipo MST61 fue identificado en una muestra leche de tanque de una finca de Montería. Las zonas de influencia de las fincas infectadas cubren totalmente la cabecera municipal y zonas periurbanas de Montería. No se detectó presencia de anticuerpos o ADN de C. burnetii en muestras de humanos estudiados. Conclusiones. El estudio demostró una importante prevalencia de C. burnetii en fincas de ganado bovino. No se halló evidencia de infección en humanos ni ovinos. Se encontró por primera vez en Colombia el genotipo MST61 de C. burnetii en leche bovina. Las características de manejo de las fincas de ganado bovino como tipo de producción tecnificada, ordeño mecánico y cuarentena para animales comprados (p-valor < 0.05) estuvieron asociados con la presencia de infección. La distribución espacial de fincas infectadas permitió identificar áreas de potencial riesgo de exposición a C. burnetii en poblaciones humanas de dos municipios y sugieren que la zona agroecológica del medio Sinú constituye un área endémica de C. burnetii en el departamento de Córdoba.spa
dc.description.abstractCoxiella burnetii is the causative agent of Q fever, a highly infectious zoonosis listed as one of the thirteen most important zoonoses worldwide. Objective. To characterize Coxiella burnetii in domestic ruminants and humans in the department of Córdoba. Methodology. A descriptive, cross-sectional study was carried out between November 2021 and November 2024. Based on a non-probabilistic sampling, 38 cattle farms, 2 cattle production associations and 24 sheep farms from 17 municipalities in the department of Córdoba, distributed in the agroecological zones: Alto, Medio and Bajo Sinú, Sabanas and Costa, were included. Bovine milk samples were taken from cooling and milking tanks (n=142), vaginal swabs from cattle (n=564) and sheep (n=171). The characteristics of the productive management of the cattle and the georeferencing points (GPS) of the farms were recorded. On the other hand, patients admitted to the San Jerónimo de Monteria hospital with symptoms compatible with undifferentiated acute febrile syndrome, atypical community-acquired pneumonia with negative culture for common germs and patients with presumptive diagnosis of endocarditis, myocarditis or pericarditis were evaluated. Samples of EDTA blood, serum, pleural fluid and bronchial secretion, and clinical-epidemiological information were collected from 37 patients. Informed consent was obtained considering the ethical standards of the Helsinki declaration and the Ministry of Health. Sera were tested by IFA for IgG antibodies against C. burnetii (phase I and II). Human and animal samples were tested by qPCR for detection of the IS1111 gene of C. burnetii. Selected positive (qPCR) samples were tested by nested PCR (rpoB gene). C. burnetii genotypes were determined by Multispacer Sequence Typing (MST) and phylogenetic analysis was performed. Areas of potential risk of infection to humans were characterized by spatial distribution analysis of infected farms using ArcGIS software. The variables studied and the frequency of infection were analyzed by descriptive statistics, Chi-square test, Odds ratio, multivariate multiple correspondence analysis and adjusted logistic regression models (Lasso and Ridge). Results. C. burnetii DNA was detected in milk samples (9.8%) and vaginal swabs (1.1%) from cattle. A total of 12.5% of cattle farms in the department of Córdoba were found to be infected with C. burnetii. No infection was found in sheep. The DNA detected revealed 100% identity with the rpoB gene of C. burnetii strains described worldwide. The MST61 genotype was identified in a tank milk sample from a farm in Monteria. The areas of influence of the infected farms totally cover the municipal capital and peri-urban areas of Monteria. No C. burnetii antibodies or DNA were detected in human samples studied. Conclusions. The study showed a significant prevalence of C. burnetii in cattle farms. No evidence of infection in humans or sheep was found. The MST61 genotype of C. burnetii was found for the first time in Colombia in bovine milk. The management characteristics of cattle farms such as type of technified production, mechanical milking and quarantine for purchased animals (p-value < 0.05) were associated with the presence of infection. The spatial distribution of infected farms allowed the identification of areas of potential risk of exposure to C. burnetii in human populations in two municipalities and suggests that the agroecological zone of the middle Sinú constitutes an endemic area of C. burnetii in the department of Córdoba.eng
dc.description.degreelevelDoctorado
dc.description.degreenameDoctor(a) en Microbiología y Salud Tropical
dc.description.modalityTrabajos de Investigación y/o Extensión
dc.description.tableofcontentsLista de acrónimosspa
dc.description.tableofcontents1. INTRODUCCIÓNspa
dc.description.tableofcontents2. OBJETIVOSspa
dc.description.tableofcontents3. MARCO TEÓRICO Y ESTADO DEL ARTEspa
dc.description.tableofcontents3.1. Características biológicas de Coxiella burnetii, importancia de la variación de la fase antigénicaspa
dc.description.tableofcontents3.1.1. Mecanismos de patogénesisspa
dc.description.tableofcontents3.1.2. Características genómicasspa
dc.description.tableofcontents3.1.3. Ancestro evolutivospa
dc.description.tableofcontents3.1.4. Genotipificación de Coxiella burnetiispa
dc.description.tableofcontents3.1.5. Comparación genómica de Coxiella burnetiispa
dc.description.tableofcontents3.2. Epidemiologia de Coxiella burnetiispa
dc.description.tableofcontents3.2.1. Reservorios y hospederosspa
dc.description.tableofcontents3.2.2. Mecanismos de transmisión.spa
dc.description.tableofcontents3.2.3. Factores de riesgo del hospederospa
dc.description.tableofcontents3.2.4 Estudios en las Américasspa
dc.description.tableofcontents3.3. Infección por Coxiella burnetii en rumiantes domésticos.spa
dc.description.tableofcontents3.4. Infección por Coxiella burnetii en humanos y manifestaciones clínicas.spa
dc.description.tableofcontents3.4.1. Infección primaria.spa
dc.description.tableofcontents3.4.2. Fiebre Q aguda.spa
dc.description.tableofcontents3.4.3. Infecciones persistentes focalizadas por Coxiella burnetii (Fiebre Q crónica).spa
dc.description.tableofcontents3.5. Respuesta inmunológicaspa
dc.description.tableofcontents3.6. Diagnóstico de laboratorio.spa
dc.description.tableofcontents3.6.1. Diagnóstico serológico.spa
dc.description.tableofcontents3.6.2. Diagnóstico por inmunohistoquímica y cultivospa
dc.description.tableofcontents3.6.3. Detección molecular.spa
dc.description.tableofcontents3.6.4. Genotipificación.spa
dc.description.tableofcontents3.7. Tratamientospa
dc.description.tableofcontents3.7.1. Tratamiento en humanosspa
dc.description.tableofcontents3.7.2. Tratamiento en animalesspa
dc.description.tableofcontents3.8. Estrategias de prevención y controlspa
dc.description.tableofcontents4. MATERIALES Y MÉTODOSspa
dc.description.tableofcontents4.1. Tiempo y tipo de estudio.spa
dc.description.tableofcontents4.2. Área geográfica de estudio.spa
dc.description.tableofcontents4.2.1. Zonas de estudio de fincas ganaderas.spa
dc.description.tableofcontents4.3. Diseño muestrealspa
dc.description.tableofcontents4.3.1. Estudio en rumiantes domésticos.spa
dc.description.tableofcontents4.3.1.1. Universo.spa
dc.description.tableofcontents4.3.1.2. Población de estudio en rumiantes y unidad de análisis.spa
dc.description.tableofcontents4.3.1.3. Tamaño de muestras.spa
dc.description.tableofcontents4.3.1.4. Tipo de muestreo en rumiantes.spa
dc.description.tableofcontents4.3.1.5. Muestreo de fincas de bovinos y ovinos.spa
dc.description.tableofcontents4.3.1.6. Variables epidemiológicas y características de manejo de fincas de rumiantesspa
dc.description.tableofcontents4.3.2. Estudio en humanos.spa
dc.description.tableofcontents4.3.2.1. Población de estudio de humanos.spa
dc.description.tableofcontents4.3.2.2. Tipo de muestreo, muestreo de pacientes, definiciones de caso, criterios de inclusión y exclusiónspa
dc.description.tableofcontents4.3.2.3. Obtención de muestras de pacientesspa
dc.description.tableofcontents4.3.2.4. Variables clínico-epidemiológicas de pacientes.spa
dc.description.tableofcontents4.4. Metodología asociada a objetivo específico 1spa
dc.description.tableofcontents4.4.1. Detección molecular de Coxiella burnetiispa
dc.description.tableofcontents4.4.1.1. Extracción de ácidos nucleicos.spa
dc.description.tableofcontents4.4.1.2. Técnica de Reacción en Cadena de la Polimerasa en Tiempo Real (qPCR) y convencional para amplificación del gen IS1111 de Coxiella burnetii.spa
dc.description.tableofcontents4.4.1.3. Detección molecular de gen rpoB de Coxiella burnetiispa
dc.description.tableofcontents4.4.1.4. Tipificación de Secuencias Multiespaciadoras (MST)spa
dc.description.tableofcontents4.4.1.5. Visualización de los productos amplificadosspa
dc.description.tableofcontents4.4.1.6. Análisis filogenéticospa
dc.description.tableofcontents4.5. Metodología asociada a objetivo específico 2 y 3spa
dc.description.tableofcontents4.5.1 Caracterización de la distribución espacial de fincas infectadas y sus áreas de influenciaspa
dc.description.tableofcontents4.5.2. Generación del evento central.spa
dc.description.tableofcontents4.5.3. Determinación de áreas de influenciaspa
dc.description.tableofcontents4.6. Metodología asociada al objetivo 4spa
dc.description.tableofcontents4.6.1. Detección molecular de Coxiella burnetii en humanosspa
dc.description.tableofcontents4.6.2 Detección serológica de anticuerpos contra Coxiella burnetii en pacientesspa
dc.description.tableofcontents4.7. Consideraciones éticasspa
dc.description.tableofcontents4.8. Metodología asociada al objetivo 5spa
dc.description.tableofcontents4.8.1. Análisis estadísticospa
dc.description.tableofcontents5. RESULTADOSspa
dc.description.tableofcontents5.1. Identificación de genotipos por MST de Coxiella burnetii circulantes en bovinos y ovinos del departamento de Córdobaspa
dc.description.tableofcontents5.1.1. Detección molecular de ADN de Coxiella burnetii en muestras de leche bovina e hisopado vaginal de bovinos y ovinosspa
dc.description.tableofcontents5.1.2. Caracterización molecular de Coxiella burnetii mediante detección del gen rpoBspa
dc.description.tableofcontents5.1.3. Genotipificación MSTspa
dc.description.tableofcontents5.1.4. Análisis filogenético de genotiposspa
dc.description.tableofcontents5.2. Frecuencia de infección en fincas ganaderasspa
dc.description.tableofcontents5.3. Determinación de áreas de riesgo potencial de infección a humanos por Coxiella burnetii en fincas ganaderas en el departamento de Córdobaspa
dc.description.tableofcontents5.3.1 Distribución geográfica de fincas infectadas por Coxiella burnetii.spa
dc.description.tableofcontents5.4. Identificación de características de manejo de fincas de ganaderas y su relación con la frecuencia de infecciónspa
dc.description.tableofcontents5.5. Frecuencia de infección por Coxiella burnetii en pacientes que ingresan al hospital San Jerónimo de Montería, con síndrome febril indiferenciado, neumonías atípicas adquiridas en comunidad, y afectaciones cardíacas como endocarditis, miocarditis y/o pericarditisspa
dc.description.tableofcontents6. DISCUSIÓNspa
dc.description.tableofcontents7. CONCLUSIONESspa
dc.description.tableofcontents8. RECOMENDACIONES Y PERSPECTIVASspa
dc.description.tableofcontents9. REFERENCIASspa
dc.description.tableofcontents10. ANEXOSspa
dc.format.mimetypeapplication/pdf
dc.identifier.instnameUniversidad de Córdoba
dc.identifier.reponameRepositorio Institucional Unicórdoba
dc.identifier.repourlhttps://repositorio.unicordoba.edu.co
dc.identifier.urihttps://repositorio.unicordoba.edu.co/handle/ucordoba/9454
dc.language.isospa
dc.publisherUniversidad de Córdoba
dc.publisher.facultyFacultad de Medicina Veterinaria y Zootecnia
dc.publisher.placeBerástegui, Córdoba, Colombia
dc.publisher.programDoctorado en Microbiología y Salud Tropical
dc.relation.references1. Sahu R, Rawool DB, Dhaka P, Yadav JP, Mishra SP, Kumar M, et al. Current perspectives on the occurrence of Q fever: highlighting the need for systematic surveillance for a neglected zoonotic disease in Indian subcontinent. Environ Microbiol Rep. 2021;13(2):138-58.
dc.relation.references2. Contreras V, González M, Guzmán C, Máttar S. Fiebre Q: una zoonosis olvidada en Colombia. Rev Médica Risaralda. julio de 2013;19(2):137-46.
dc.relation.references3. Barlow J, Rauch B, Welcome F, Kim S, Dubovi E, Schukken Y. Association between Coxiella burnetii shedding in milk and subclinical mastitis in dairy cattle. Vet Res. 2008;39(3):1
dc.relation.references4. Saegerman C, Grégoire F, Delooz L. Diagnosis of Coxiella burnetii Cattle Abortion: A One-Year Observational Study. Pathogens. abril de 2022;11(4):429.
dc.relation.references5. Macías-Rioseco M, Riet-Correa F, Miller MM, Sondgeroth K, Fraga M, Silveira C, et al. Bovine abortion caused by Coxiella burnetii: report of a cluster of cases in Uruguay and review of the literature. J Vet Diagn Invest. 1 de julio de 2019;31(4):634-9.
dc.relation.references6. Schimmer B, ter Schegget R, Wegdam M, Züchner L, de Bruin A, Schneeberger PM, et al. The use of a geographic information system to identify a dairy goat farm as the most likely source of an urban Q-fever outbreak. BMC Infect Dis. 16 de marzo de 2010;10(1):69.
dc.relation.references7. Tissot-Dupont H, Amadei MA, Nezri M, Raoult D. Wind in November, Q Fever in December. Emerg Infect Dis. julio de 2004;10(7):1264-9.
dc.relation.references8. van der Hoek W, Hunink J, Vellema P, Droogers P. Q fever in The Netherlands: the role of local environmental conditions. Int J Environ Health Res. 1 de diciembre de 2011;21(6):441-51.
dc.relation.references9. Epelboin L, De Souza Ribeiro Mioni M, Couesnon A, Saout M, Guilloton E, Omar S, et al. Coxiella burnetii Infection in Livestock, Pets, Wildlife, and Ticks in Latin America and the Caribbean: a Comprehensive Review of the Literature. Curr Trop Med Rep. 1 de septiembre de 2023;10(3):94-137.
dc.relation.references10. Mioni M de SR, Sidi-Boumedine K, Morales Dalanezi F, Fernandes Joaquim S, Denadai R, Reis Teixeira WS, et al. New Genotypes of Coxiella burnetii Circulating in Brazil and Argentina. Pathogens. enero de 2020;9(1):30.
dc.relation.references11. Mioni M de SR, Henker LC, Teixeira WSR, Lorenzett MP, Labruna MB, Pavarini SP, et al. Molecular detection of Coxiella burnetii in aborted bovine fetuses in Brazil. Acta Trop. 1 de marzo de 2022;227:106258.
dc.relation.references12. de Oliveira JMB, Rozental T, de Lemos ERS, Forneas D, Ortega-Mora LM, Porto WJN, et al. Coxiella burnetii in dairy goats with a history of reproductive disorders in Brazil. Acta Trop. 1 de julio de 2018;183:19-22.
dc.relation.references13. Nascimento C de F, de Mello VVC, Machado RZ, André MR, Bürger KP. Molecular Detection of Coxiella burnetii in Unstandardized Minas Artisanal Cheese Marketed in Southeastern Brazil. Acta Trop. 1 de agosto de 2021;220:105942.
dc.relation.references14. Rozental T, Faria LS de, Silva MR, Ribeiro JB, Araujo FR, Costa RR da, et al. Ocorrência de Coxiella burnetii em queijo Minas artesanal de leite cru: resultados preliminares de um preocupante problema de saúde pública. 2018 [citado 5 de noviembre de 2024]; Disponible en: http://www.alice.cnptia.embrapa.br/handle/doc/1117128
dc.relation.references15. Rojas MI, Barragán V, P GAT, O’Neill HMH, Pearson T, Keim P. Detección de Coxiella burnetii en leche de bovinos domésticos del Ecuador. ACI Av En Cienc E Ing [Internet]. 8 de abril de 2013 [citado 5 de noviembre de 2024];5(1).
dc.relation.references16. Cornejo J, Araya P, Ibáñez D, Hormazabal JC, Retamal P, Fresno M, et al. Identification of Coxiella burnetii in Tank Raw Cow Milk: First Findings from Chile. Vector-Borne Zoonotic Dis. marzo de 2020;20(3):228-30
dc.relation.references17. Hernández-Agudelo JM, Bartolotti C, Tejeda C, Tomckowiak C, Soto JP, Steuer P, et al. Molecular and serological prevalence of Coxiella burnetii in bovine dairy herds in southern Chile: A PCR and ELISA-based assessment of bulk tank milk samples. Acta Trop. 1 de noviembre de 2023;247:107008.
dc.relation.references18. Macías-Rioseco M, Silveira C, Fraga M, Casaux L, Cabrera A, Francia ME, et al. Causes of abortion in dairy cows in Uruguay. Pesqui Veterinária Bras. 17 de julio de 2020;40:325-32
dc.relation.references19. Máttar S, Parra M. Detección de anticuerpos contra Anaplasma, Bartonella and Coxiella en habitantes rurales de un área del caribe colombiano. Rev MVZ Córdoba [Internet]. 1 de julio de 2006 [citado 19 de noviembre de 2023];11(2).
dc.relation.references20. Mattar V S, Contreras C V, Gonzalez T M, Camargo F, Alvarez J, Oteo JA. Infection by Coxiella burnetii in a patient from a rural area of Monteria, Colombia. Rev Salud Pública. 16 de julio de 2015;16(6):958-61.
dc.relation.references21. Contreras V, Máttar S, González M, Álvarez J, Oteo JA. Coxiella burnetii in bulk tank milk and antibodies in farm workers at Montería, Colombia. Rev Colomb Cienc Pecu. 17 de abril de 2015;28(2):181-7.
dc.relation.references22. Contreras V, Gonzalez M, Alvarez J, Mattar S. Coxiella burnetii infection in sheep and goats: a public risk health, Colombia. Infectio. 2 de julio de 2018;173-7.
dc.relation.references23. Orrego RC, Ríos-Osorio LA, Keynan Y, Rueda ZV, Gutiérrez LA. Molecular detection of Coxiella burnetii in livestock farmers and cattle from Magdalena Medio in Antioquia, Colombia. PLOS ONE. 10 de junio de 2020;15(6):e0234360.
dc.relation.references24. Nusinovici S, Hoch T, Brahim ML, Joly A, Beaudeau F. The Effect of Wind on Coxiella burnetii Transmission Between Cattle Herds: a Mechanistic Approach. Transbound Emerg Dis. 2017;64(2):585-92.
dc.relation.references25. Eldin C, Mélenotte C, Mediannikov O, Ghigo E, Million M, Edouard S, et al. From Q Fever to Coxiella burnetii Infection: a Paradigm Change. Clin Microbiol Rev. enero de 2017;30(1):115-90.
dc.relation.references26. Million M, Walter G, Thuny F, Habib G, Raoult D. Evolution From Acute Q Fever to Endocarditis Is Associated With Underlying Valvulopathy and Age and Can Be Prevented by Prolonged Antibiotic Treatment. Clin Infect Dis. 15 de septiembre de 2013;57(6):836-44.
dc.relation.references27. Bauer BU, Knittler MR, Andrack J, Berens C, Campe A, Christiansen B, et al. Interdisciplinary studies on Coxiella burnetii: From molecular to cellular, to host, to one health research. Int J Med Microbiol. 1 de noviembre de 2023;313(6):151590
dc.relation.references28. Nielsen SY, Nørskov-Lauritsen N. Multispacer sequence typing of Coxiella burnetii DNA from removed prosthetic heart valve material discloses first human case of infective endocarditis caused by MST_18. Int J Infect Dis. 1 de febrero de 2019;79:139-41
dc.relation.references29. Edouard S, Mahamat A, Demar M, Abboud P, Djossou F, Raoult D. Comparison between Emerging Q Fever in French Guiana and Endemic Q fever in Marseille, France. Am J Trop Med Hyg. 7 de mayo de 2014;90(5):915-9.
dc.relation.references30. Mioni M de SR, Sidi-Boumedine K, Morales Dalanezi F, Fernandes Joaquim S, Denadai R, Reis Teixeira WS, et al. New Genotypes of Coxiella burnetii Circulating in Brazil and Argentina. Pathogens. enero de 2020;9(1):30.
dc.relation.references31. Dijkstra F, van der Hoek W, Wijers N, Schimmer B, Rietveld A, Wijkmans CJ, et al. The 2007–2010 Q fever epidemic in the Netherlands: characteristics of notified acute Q fever patients and the association with dairy goat farming. FEMS Immunol Med Microbiol. 1 de febrero de 2012;64(1):3-12
dc.relation.references32. Mattar V S, Contreras C V, Gonzalez T M, Camargo F, Alvarez J, Oteo R J. Infection by Coxiella burnetii in a patient from a rural area of Monteria, Colombia. Rev Salud Pública. 16 de julio de 2015;16(6):958-61.
dc.relation.references33. Tapia T, Olivares MF, Stenos J, Iglesias R, Díaz N, Vergara N, et al. National Seroprevalence of Coxiella burnetii in Chile, 2016–2017. Pathogens. mayo de 2021;10(5):531.
dc.relation.references34. Mares-Guia MAMM, Rozental T, Guterres A, Ferreira M dos S, Botticini RDG, Terra AKC, et al. Molecular Identification of Q Fever in Patients with a Suspected Diagnosis of Dengue in Brazil in 2013–2014. Am J Trop Med Hyg. 4 de mayo de 2016;94(5):1090
dc.relation.references35. Cardona JCM. Neumonía por Coxiella burnetii: presentación de un caso y revisión de la literatura / Coxiella burnetii pneumonia: Case report and literature review. CES Med. 14 de diciembre de 2012;26(2):201-8.
dc.relation.references36. Uribe Pulido N, Escorcia García C, Cabrera Orrego R, Gutiérrez LA, Agudelo CA. Acute Q Fever With Dermatologic Manifestations, Molecular Diagnosis, and No Seroconversion. Open Forum Infect Dis. 1 de octubre de 2021;8(10):ofab458.
dc.relation.references37. Betancur CA, Múnera AG. Endocarditis por Coxiella burnetii: Acta Médica Colomb. 2012;37(1):31-3
dc.relation.references38. Montufar F, Rueda Z, Correa L, Vélez L, Ortega H, Ortega J. Características y comportamiento de la Neumonía Adquirida en la Comunidad (NAC) en adultos mayores (≥ 65 años) hospitalizados en el Valle de Aburrá, Antioquia, Colombia. Infectio. 1 de enero de 2006;10.
dc.relation.references39. Valade S, Biard L, Lemiale V, Argaud L, Pène F, Papazian L, et al. Severe atypical pneumonia in critically ill patients: a retrospective multicenter study. Ann Intensive Care. 13 de agosto de 2018;8(1):81.
dc.relation.references40. Jang YR, Song JS, Jin CE, Ryu BH, Park SY, Lee SO, et al. Molecular detection of Coxiella burnetii in heart valve tissue from patients with culture-negative infective endocarditis. Medicine (Baltimore). 24 de agosto de 2018;97(34):e11881.
dc.relation.references41. Shaw EI, Voth DE. Coxiella burnetii: A Pathogenic Intracellular Acidophile. Microbiology. enero de 2019;165(1):1-3.
dc.relation.references42. Beare PA, Jeffrey BM, Long CM, Martens CM, Heinzen RA. Genetic mechanisms of Coxiella burnetii lipopolysaccharide phase variation. PLoS Pathog. 26 de febrero de 2018;14(3):e1006922.
dc.relation.references43. Narasaki CT, Toman R. Lipopolysaccharide of Coxiella burnetii. Coxiella Burn Recent Adv New Perspect Res Q Fever Bact. 2012;65-90.
dc.relation.references44. Right on Q: genetics begin to unravel Coxiella burnetii host cell interactions | Future Microbiology [Internet]. [citado 27 de enero de 2023]. Disponible en: https://www.futuremedicine.com/doi/full/10.2217/fmb-2016-0044
dc.relation.references45. Sandoz KM, Popham DL, Beare PA, Sturdevant DE, Hansen B, Nair V, et al. Transcriptional Profiling of Coxiella burnetii Reveals Extensive Cell Wall Remodeling in the Small Cell Variant Developmental Form. PLOS ONE. 24 de febrero de 2016;11(2):e0149957.
dc.relation.references46. Coleman SA, Fischer ER, Howe D, Mead DJ, Heinzen RA. Temporal Analysis of Coxiella burnetii Morphological Differentiation. J Bacteriol. noviembre de 2004;186(21):7344-52.
dc.relation.references47. Oyston PCF, Davies C. Q fever: the neglected biothreat agent. J Med Microbiol. 2011;60(1):9-21.
dc.relation.references48. Voth DE, Heinzen RA. Lounging in a lysosome: the intracellular lifestyle of Coxiella burnetii. Cell Microbiol. 2007;9(4):829-40.
dc.relation.references49. Dragan AL, Voth DE. Coxiella burnetii: international pathogen of mystery. Microbes Infect. 1 de abril de 2020;22(3):100-10.
dc.relation.references50. Mulye M, Zapata B, Gilk SD. Altering lipid droplet homeostasis affects Coxiella burnetii intracellular growth. PLOS ONE. 1 de febrero de 2018;13(2):e0192215.
dc.relation.references51. Voth DE, Heinzen RA. Coxiella type IV secretion and cellular microbiology. Curr Opin Microbiol. 1 de febrero de 2009;12(1):74-80.
dc.relation.references52. Seshadri R, Paulsen IT, Eisen JA, Read TD, Nelson KE, Nelson WC, et al. Complete genome sequence of the Q-fever pathogen Coxiella burnetii. Proc Natl Acad Sci. 29 de abril de 2003;100(9):5455-60.
dc.relation.references53. Zamboni DS, McGrath S, Rabinovitch M, Roy CR. Coxiella burnetii express type IV secretion system proteins that function similarly to components of the Legionella pneumophila Dot/Icm system. Mol Microbiol. 2003;49(4):965-76.
dc.relation.references54. van Schaik EJ, Chen C, Mertens K, Weber MM, Samuel JE. Molecular pathogenesis of the obligate intracellular bacterium Coxiella burnetii. Nat Rev Microbiol. agosto de 2013;11(8):561-73.
dc.relation.references55. Duron O, Noël V, McCoy KD, Bonazzi M, Sidi-Boumedine K, Morel O, et al. The Recent Evolution of a Maternally-Inherited Endosymbiont of Ticks Led to the Emergence of the Q Fever Pathogen, Coxiella burnetii. PLOS Pathog. 15 de mayo de 2015;11(5):e1004892.
dc.relation.references56. Brenner AE, Muñoz-Leal S, Sachan M, Labruna MB, Raghavan R. Coxiella burnetii and Related Tick Endosymbionts Evolved from Pathogenic Ancestors. Genome Biol Evol. 1 de julio de 2021;13(7):evab108.
dc.relation.references57. Pearson T, Hornstra HM, Sahl JW, Schaack S, Schupp JM, Beckstrom-Sternberg SM, et al. When Outgroups Fail; Phylogenomics of Rooting the Emerging Pathogen, Coxiella burnetii. Syst Biol. 1 de septiembre de 2013;62(5):752-62.
dc.relation.references58. Beare PA, Samuel JE, Howe D, Virtaneva K, Porcella SF, Heinzen RA. Genetic Diversity of the Q Fever Agent, Coxiella burnetii, Assessed by Microarray-Based Whole-Genome Comparisons. J Bacteriol. abril de 2006;188(7):2309-24.
dc.relation.references59. Duron O. The IS1111 insertion sequence used for detection of Coxiella burnetii is widespread in Coxiella-like endosymbionts of ticks. FEMS Microbiol Lett. 1 de septiembre de 2015;362(17):fnv132.
dc.relation.references60. Beare PA, Unsworth N, Andoh M, Voth DE, Omsland A, Gilk SD, et al. Comparative Genomics Reveal Extensive Transposon-Mediated Genomic Plasticity and Diversity among Potential Effector Proteins within the Genus Coxiella. Infect Immun. febrero de 2009;77(2):642-56.
dc.relation.references61. Piñero A, Barandika JF, García-Pérez AL, Hurtado A. Genetic diversity and variation over time of Coxiella burnetii genotypes in dairy cattle and the farm environment. Infect Genet Evol. 1 de abril de 2015;31:231-5.
dc.relation.references62. Hornstra HM, Priestley RA, Georgia SM, Kachur S, Birdsell DN, Hilsabeck R, et al. Rapid Typing of Coxiella burnetii. PLOS ONE. 2 de noviembre de 2011;6(11):e26201.
dc.relation.references63. Jäger C, Willems H, Thiele D, Baljer G. Molecular characterization of Coxiella burnetii isolates. Epidemiol Infect. marzo de 1998;120(2):157-64.
dc.relation.references64. D’Amato F, Eldin C, Raoult D. The Contribution of Genomics to the Study of Q Fever. Future Microbiol. 1 de febrero de 2016;11(2):253-72.
dc.relation.references65. Arricau-Bouvery N, Hauck Y, Bejaoui A, Frangoulidis D, Bodier CC, Souriau A, et al. Molecular characterization of Coxiella burnetii isolates by infrequent restriction site-PCR and MLVA typing. BMC Microbiol. 26 de abril de 2006;6(1):38.
dc.relation.references66. Jäger C, Willems H, Thiele D, Baljer G. Molecular characterization of Coxiella burnetii isolates. Epidemiol Infect. marzo de 1998;120(2):157-64.
dc.relation.references67. Svraka S, Toman R, Skultety L, Slaba K, Homan WL. Establishment of a genotyping scheme for Coxiella burnetii. FEMS Microbiol Lett. 1 de enero de 2006;254(2):268-74.
dc.relation.references68. Santos AS, Tilburg JJHC, Botelho A, Barahona MJ, Núncio MS, Nabuurs-Franssen MH, et al. Genotypic diversity of clinical Coxiella burnetii isolates from Portugal based on MST and MLVA typing. Int J Med Microbiol. 1 de noviembre de 2012;302(6):253-6.
dc.relation.references69. Glazunova O, Roux V, Freylikman O, Sekeyova Z, Fournous G, Tyczka J, et al. Coxiella burnetii Genotyping. Emerg Infect Dis. agosto de 2005;11(8):1211.
dc.relation.references70. Abou Abdallah R, Million M, Delerce J, Anani H, Diop A, Caputo A, et al. Pangenomic analysis of Coxiella burnetii unveils new traits in genome architecture. Front Microbiol [Internet]. 2022 [citado 23 de noviembre de 2023];13. Disponible en: https://www.frontiersin.org/articles/10.3389/fmicb.2022.1022356
dc.relation.references71. Hemsley CM, Essex-Lopresti A, Norville IH, Titball RW. Correlating Genotyping Data of Coxiella burnetii with Genomic Groups. Pathogens. mayo de 2021;10(5):604.
dc.relation.references72. Abou Abdallah R, Million M, Delerce J, Anani H, Diop A, Caputo A, et al. Pangenomic analysis of Coxiella burnetii unveils new traits in genome architecture. Front Microbiol [Internet]. 2022 [citado 23 de noviembre de 2023];13.
dc.relation.references73. Mahamat A, Edouard S, Demar M, Abboud P, Patrice JY, La Scola B, et al. Unique Clone of Coxiella burnetii Causing Severe Q Fever, French Guiana. Emerg Infect Dis. julio de 2013;19(7):1102-4.
dc.relation.references74. D’Amato F, Eldin C, Georgiades K, Edouard S, Delerce J, Labas N, et al. Loss of TSS1 in hypervirulent Coxiella burnetii 175, the causative agent of Q fever in French Guiana. Comp Immunol Microbiol Infect Dis. 1 de agosto de 2015;41:35-41.
dc.relation.references75. Angelakis E, Million M, D’Amato F, Rouli L, Richet H, Stein A, et al. Q fever and pregnancy: disease, prevention, and strain specificity. Eur J Clin Microbiol Infect Dis. 1 de marzo de 2013;32(3):361-8.
dc.relation.references76. Ruiz-Fons F, Rodríguez Ó, Torina A, Naranjo V, Gortázar C, de la Fuente J. Prevalence of Coxiella burnetti infection in wild and farmed ungulates. Vet Microbiol. 1 de enero de 2008;126(1):282-6.
dc.relation.references77. Berri M, Laroucau K, Rodolakis A. The detection of Coxiella burnetii from ovine genital swabs, milk and fecal samples by the use of a single touchdown polymerase chain reaction. Vet Microbiol. 15 de marzo de 2000;72(3):285-93.
dc.relation.references78. Guatteo R, Beaudeau F, Berri M, Rodolakis A, Joly A, Seegers H. Shedding routes of Coxiella burnetii in dairy cows: implications for detection and control. Vet Res. 2006;37(6):827.
dc.relation.references79. Rodolakis A, Berri M, Héchard C, Caudron C, Souriau A, Bodier CC, et al. Comparison of Coxiella burnetii Shedding in Milk of Dairy Bovine, Caprine, and Ovine Herds. J Dairy Sci. 1 de diciembre de 2007;90(12):5352-60.
dc.relation.references80. Zhong J. Coxiella-like Endosymbionts. En: Toman R, Heinzen RA, Samuel JE, Mege JL, editores. Coxiella burnetii: Recent Advances and New Perspectives in Research of the Q Fever Bacterium [Internet]. Dordrecht: Springer Netherlands; 2012 [citado 29 de enero de 2023]. p. 365-79. (Advances in Experimental Medicine and Biology).
dc.relation.references81. Duron O, Sidi-Boumedine K, Rousset E, Moutailler S, Jourdain E. The Importance of Ticks in Q Fever Transmission: What Has (and Has Not) Been Demonstrated? Trends Parasitol. 1 de noviembre de 2015;31(11):536-52.
dc.relation.references82. Körner S, Makert GR, Mertens-Scholz K, Henning K, Pfeffer M, Starke A, et al. Uptake and fecal excretion of Coxiella burnetii by Ixodes ricinus and Dermacentor marginatus ticks. Parasit Vectors. 14 de febrero de 2020;13(1):75.
dc.relation.references83. Mares-Guia MAMM, Guterres A, Rozental T, Ferreira M dos S, Lemos ERS. Clinical and epidemiological use of nested PCR targeting the repetitive element IS1111 associated with the transposase gene from Coxiella burnetii. Braz J Microbiol. marzo de 2018;49:138-43.
dc.relation.references84. Pacheco RC, Echaide IE, Alves RN, Beletti ME, Nava S, Labruna MB. Coxiella burnetii in Ticks, Argentina. Emerg Infect Dis. febrero de 2013;19(2):344-6.
dc.relation.references85. Noda AA, Rodríguez I, Miranda J, Contreras V, Mattar S. First molecular evidence of Coxiella burnetii infecting ticks in Cuba. Ticks Tick-Borne Dis. 1 de febrero de 2016;7(1):68-70.
dc.relation.references86. Davoust B, Marié JL, Santi VP de, Berenger JM, Edouard S, Raoult D. Three-Toed Sloth as Putative Reservoir of Coxiella burnetii, Cayenne, French Guiana. Emerg Infect Dis. octubre de 2014;20(10):1760.
dc.relation.references87. Buysse M, Duron O. Evidence that microbes identified as tick-borne pathogens are nutritional endosymbionts. Cell. 29 de abril de 2021;184(9):2259-60.
dc.relation.references88. Human dose response relation for airborne exposure to Coxiella burnetii | BMC Infectious Diseases | Full Text [Internet]. [citado 29 de enero de 2023]
dc.relation.references89. Wind in November, Q Fever in December [Internet]. [citado 29 de enero de 2023]. Disponible en: https://stacks.cdc.gov/view/cdc/14491
dc.relation.references90. Sahu R, Yadav JP, Vergis J, Rawool DB, Malik SVS, Barbuddhe SB. Coxiella and Q fever. En: Tang YW, Hindiyeh MY, Liu D, Sails A, Spearman P, Zhang JR, editores. Molecular Medical Microbiology (Third Edition) [Internet]. Academic Press; 2024 p. 1811-47
dc.relation.references91. Eldin C, Mélenotte C, Mediannikov O, Ghigo E, Million M, Edouard S, et al. From Q Fever to Coxiella burnetii Infection: a Paradigm Change. Clin Microbiol Rev. enero de 2017;30(1):115-90.
dc.relation.references92. Nielsen SY, Mølbak K, Henriksen TB, Krogfelt KA, Larsen CS, Villumsen S. Adverse Pregnancy Outcomes and Coxiella burnetii Antibodies in Pregnant Women, Denmark. Emerg Infect Dis. junio de 2014;20(6):925-31.
dc.relation.references93. Amara AB, Ghigo E, Priol YL, Lépolard C, Salcedo SP, Lemichez E, et al. Coxiella burnetii, the Agent of Q Fever, Replicates within Trophoblasts and Induces a Unique Transcriptional Response. PLOS ONE. 14 de diciembre de 2010;5(12):e15315.
dc.relation.references94. Benoit M, Thuny F, Priol YL, Lepidi H, Bastonero S, Casalta JP, et al. The Transcriptional Programme of Human Heart Valves Reveals the Natural History of Infective Endocarditis. PLOS ONE. 28 de enero de 2010;5(1):e8939.
dc.relation.references95. Thuny F, Textoris J, Amara AB, Filali AE, Capo C, Habib G, et al. The Gene Expression Analysis of Blood Reveals S100A11 and AQP9 as Potential Biomarkers of Infective Endocarditis. PLOS ONE. 3 de febrero de 2012;7(2):e31490.
dc.relation.references96. Cripe L, Andelfinger G, Martin LJ, Shooner K, Benson DW. Bicuspid aortic valve is heritable. J Am Coll Cardiol. 7 de julio de 2004;44(1):138-43.
dc.relation.references97. Schoffelen T, Wong A, Rümke HC, Netea MG, Timen A, van Deuren M, et al. Adverse events and association with age, sex and immunological parameters of Q fever vaccination in patients at risk for chronic Q fever in the Netherlands 2011. Vaccine. 20 de noviembre de 2014;32(49):6622-30.
dc.relation.references98. McQuiston JH, Childs JE. Q Fever in Humans and Animals in the United States. Vector-Borne Zoonotic Dis. septiembre de 2002;2(3):179-91.
dc.relation.references99. Miller HK, Branan M, Priestley RA, Álvarez-Alonso R, Cherry C, Smith C, et al. Coxiella burnetii in domestic doe goats in the United States, 2019–2020. Front Vet Sci [Internet]. 7 de mayo de 2024 [citado 5 de noviembre de 2024];11.
dc.relation.references100. Welch JL, Branan M, Urie N, Shrestha R, Wiedenheft A, Marshall K, et al. Coxiella burnetii seroprevalence in domestic goat does in the United States: Prevalence, distribution, and associated risk factors. Prev Vet Med. 1 de febrero de 2024;223:106114.
dc.relation.references101. Pearson T, Hornstra HM, Hilsabeck R, Gates LT, Olivas SM, Birdsell DM, et al. High prevalence and two dominant host-specific genotypes of Coxiella burnetii in U.S. milk. BMC Microbiol. 17 de febrero de 2014;14(1):41.
dc.relation.references102. Olivas S, Hornstra H, Priestley RA, Kaufman E, Hepp C, Sonderegger DL, et al. Massive dispersal of Coxiella burnetii among cattle across the United States. Microb Genomics. 2016;2(8):e000068.
dc.relation.references103. Villagra-Blanco R, Esquivel-Suárez A, Wagner H, Romero-Zúñiga JJ, Taubert A, Wehrend A, et al. Seroprevalence and factors associated with Toxoplasma gondii-, Neospora caninum- and Coxiella burnetii-infections in dairy goat flocks from Costa Rica. Vet Parasitol Reg Stud Rep. 1 de diciembre de 2018;14:79-84
dc.relation.references104. Salinas-Melédez J, Avalos-Ramírez R, Riojas-Valdez V, Kawas J, Fimbres-Durazo H, Hernández Vidal G. Serologic survey in animals of «Q» fever in Nuevo Leon. Rev Latinoam Microbiol. 1 de abril de 2002;44:75-8.
dc.relation.references105. Flores Pérez C, Díaz Aparicio E, Palomares Reséndiz EG, Gutiérrez Hernández JL, Herrera López E, Hernández Castro R. Molecular detection of Coxiella burnetii in vaginal swabs from aborted cattle in Mexico. Rev Colomb Cienc Pecu. 2024;37(1):52-9.
dc.relation.references106. Oropeza M, Dickson L, Maldonado J, Kowalski A. Seropositividad a Coxiella burnetii en cabras de la parroquia Trinidad Samuel del municipio Torres, estado Lara, Venezuela. Zootec Trop. diciembre de 2010;28(4):557-60.
dc.relation.references107. Cornejo J, Araya P, Ibáñez D, Hormazabal JC, Retamal P, Fresno M, et al. Identification of Coxiella burnetii in Tank Raw Cow Milk: First Findings from Chile. Vector-Borne Zoonotic Dis. marzo de 2020;20(3):228-30.
dc.relation.references108. Carbonero A, Guzmán LT, Montaño K, Torralbo A, Arenas-Montes A, Saa LR. Coxiella burnetii seroprevalence and associated risk factors in dairy and mixed cattle farms from Ecuador. Prev Vet Med. 1 de marzo de 2015;118(4):427-35.
dc.relation.references109. Echeverría G, Reyna-Bello A, Minda-Aluisa E, Celi-Erazo M, Olmedo L, García HA, et al. Serological evidence of Coxiella burnetii infection in cattle and farm workers: is Q fever an underreported zoonotic disease in Ecuador? Infect Drug Resist. 9 de abril de 2019;12:701-6.
dc.relation.references110. Zanatto DCS, Gatto IRH, Labruna MB, Jusi MMG, Samara SI, Machado RZ, et al. Coxiella burnetii associated with BVDV (Bovine Viral Diarrhea Virus), BoHV (Bovine Herpesvirus), Leptospira spp., Neospora caninum, Toxoplasma gondii and Trypanosoma vivax in reproductive disorders in cattle. Rev Bras Parasitol Veterinária. 13 de junio de 2019;28:245-57.
dc.relation.references111. Kaplan MM, Bertagna P. The geographical distribution of Q fever. Bull World Health Organ. 1955;13(5):829.
dc.relation.references112. Mares-Guia MAM de M, Rozental T, Guterres A, Gomes R, Almeida DN de, Moreira NS, et al. Molecular identification of the agent of Q fever – Coxiella burnetii – in domestic animals in State of Rio de Janeiro, Brazil. Rev Soc Bras Med Trop. abril de 2014;47:231-4.
dc.relation.references113. Zanatto DC de S, Duarte JMB, Labruna MB, Tasso JB, Calchi AC, Machado RZ, et al. Evidence of exposure to Coxiella burnetii in neotropical free-living cervids in South America. Acta Trop. 1 de septiembre de 2019;197:105037.
dc.relation.references114. Gardon J, Héraud J, Laventure S, Ladam A, Capot P, Fouquet E, et al. Suburban Transmission of Q Fever in French Guiana: Evidence of a Wild Reservoir. J Infect Dis. 1 de agosto de 2001;184(3):278-84.
dc.relation.references115. de Oliveira GMB, da Silva IWG, da Cruz Ferreira Evaristo AM, de Azevedo Serpa MC, Silva Campos AN, Dutra V, et al. Tick-borne pathogens in dogs, wild small mammals and their ectoparasites in the semi-arid Caatinga biome, northeastern Brazil. Ticks Tick-Borne Dis. 1 de julio de 2020;11(4):101409.
dc.relation.references116. Christen JR, Edouard S, Lamour T, Martinez E, Rousseau C, Laval F de, et al. Capybara and Brush Cutter Involvement in Q Fever Outbreak in Remote Area of Amazon Rain Forest, French Guiana, 2014. Emerg Infect Dis. mayo de 2020;26(5):993.
dc.relation.references117. Rozental T, Ferreira MS, Guterres A, Mares-Guia MA, Teixeira BR, Gonçalves J, et al. Zoonotic pathogens in Atlantic Forest wild rodents in Brazil: Bartonella and Coxiella infections. Acta Trop. 1 de abril de 2017;168:64-73.
dc.relation.references118. Ferreira MS, Guterres A, Rozental T, Novaes RLM, Vilar EM, Oliveira RC de, et al. Coxiella and Bartonella spp. in bats (Chiroptera) captured in the Brazilian Atlantic Forest biome. BMC Vet Res. 10 de septiembre de 2018;14(1):279.
dc.relation.references119. Müller A, Sepúlveda P, Di Cataldo S, Cevidanes A, Lisón F, Millán J. Molecular investigation of zoonotic intracellular bacteria in Chilean bats. Comp Immunol Microbiol Infect Dis. 1 de diciembre de 2020;73:101541.
dc.relation.references120. Silva-Ramos CR, Faccini-Martínez ÁA, Pérez-Torres J, Hidalgo M, Cuervo C. First molecular evidence of Coxiella burnetii in bats from Colombia. Res Vet Sci. 5 de diciembre de 2022;150:33-5.
dc.relation.references121. Han HJ, Wen H ling, Zhou CM, Chen FF, Luo LM, Liu J wei, et al. Bats as reservoirs of severe emerging infectious diseases. Virus Res. 2 de julio de 2015;205:1-6.
dc.relation.references122. El Zein S, Challener DW, Ranganath N, Khodadadi RB, Theel ES, Abu Saleh OM. Acute Coxiella burnetii Infection: A 10-Year Clinical Experience at a Tertiary Care Center in the United States. Open Forum Infect Dis. 1 de junio de 2024;11(6):ofae277.
dc.relation.references123. Betancur CA, Rubio M, Barrera J, Bedoya JC. Seroprevalencia de Coxiella burnetii en trabajadores de fincas ganaderas del departamento de Antioquia 2011-2012. Acta Médica Colomb. 6 de mayo de 2015;40(1):20-3.
dc.relation.references124. Cabrera R, Mendoza W, López-Mosquera L, Cano MA, Ortiz N, Campo V, et al. Tick-Borne-Agents Detection in Patients with Acute Febrile Syndrome and Ticks from Magdalena Medio, Colombia. Pathogens. octubre de 2022;11(10):1090.
dc.relation.references125. Weitzel T, López J, Acosta-Jamett G, Edouard S, Parola P, Abarca K. Absence of convincing evidence of Coxiella burnetii infection in Chile: a cross-sectional serosurvey among healthy adults in four different regions. BMC Infect Dis. 6 de octubre de 2016;16(1):541.
dc.relation.references126. Tapia T, Stenos J, Flores R, Duery O, Iglesias R, Olivares MF, et al. Evidence of Q Fever and Rickettsial Disease in Chile. Trop Med Infect Dis. junio de 2020;5(2):99.
dc.relation.references127. Tapia T, Olivares MF, Stenos J, Iglesias R, Díaz N, Vergara N, et al. National Seroprevalence of Coxiella burnetii in Chile, 2016–2017. Pathogens. mayo de 2021;10(5):531.
dc.relation.references128. Brandão H, Vale LAR do, Christovão D de A. INVESTIGAÇõES SÔBRE A FEBRE «Q» EM SÃO PAULO. I - ESTUDO SOROLÓGICO EM OPERÁRIOS DE UM FRIGORÍFICO. Arq Fac Hig E Saúde Pública Universidade São Paulo. 1 de junio de 1953;7(1):127-31.
dc.relation.references129. Costa PSG da, Brigatte ME, Greco DB. Antibodies to Rickettsia rickettsii, Rickettsia typhi, Coxiella burnetii, Bartonella henselae, Bartonella quintana, and Ehrlichia chaffeensis among healthy population in Minas Gerais, Brazil. Mem Inst Oswaldo Cruz. diciembre de 2005;100:853-9.
dc.relation.references130. Siciliano RF, Strabelli TM, Zeigler R, Rodrigues C, Cas℡li JB, Grinberg M, et al. Infective Endocarditis due to Bartonella spp. and Coxiella burnetii. Ann N Y Acad Sci. 2006;1078(1):215-22.
dc.relation.references131. Costa PSG da, Brigatte ME, Greco DB. Questing one Brazilian query: reporting 16 cases of Q fever from Minas Gerais, Brazil. Rev Inst Med Trop São Paulo. febrero de 2006;48:5-9.
dc.relation.references132. Siciliano RF, Ribeiro HB, Furtado RH de M, Castelli JB, Sampaio RO, Santos FCP dos, et al. Endocardite por Coxiella burnetii (febre Q): doença rara ou pouco diagnosticada? Relato de caso. Rev Soc Bras Med Trop. agosto de 2008;41:409-12.
dc.relation.references133. Lamas CC, Rozental T, Bóia MN, Favacho ARM, Kirsten AH, Silva APM da, et al. Seroprevalence of Coxiella burnetii antibodies in human immunodeficiency virus-positive patients in Jacarepaguá, Rio de Janeiro, Brazil. Clin Microbiol Infect. 1 de diciembre de 2009;15:140-1.
dc.relation.references134. Lemos ERS, Rozental T, Mares-Guia MAM, Almeida DNP, Moreira N, Silva RG, et al. Q Fever as a Cause of Fever of Unknown Origin and Thrombocytosis: First Molecular Evidence of Coxiella burnetii in Brazil. Vector-Borne Zoonotic Dis. enero de 2011;11(1):85-7.
dc.relation.references135. Lamas C da C, Ramos RG, Lopes GQ, Santos MS, Golebiovski WF, Weksler C, et al. Bartonella and Coxiella infective endocarditis in Brazil: molecular evidence from excised valves from a cardiac surgery referral center in Rio de Janeiro, Brazil, 1998 to 2009. Int J Infect Dis. 1 de enero de 2013;17(1):e65-6.
dc.relation.references136. Meurer IR, Silva MR, Silva MVF, Duré AÍDL, Adelino TÉR, Costa AVBD, et al. SOROPREVALÊNCIA DE ANTICORPOS ANTI‐COXIELLA BURNETII EM PACIENTES COM SUSPEITA DE DENGUE NO ESTADO DE MINAS GERAIS, BRASIL. Braz J Infect Dis. enero de 2021;25:101415.
dc.relation.references137. França DA de, Mioni M de SR, Fornazari F, Duré AÍ de L, Silva MVF, Possebon FS, et al. Seropositivity for Coxiella burnetii in suspected patients with dengue in São Paulo state, Brazil. PLoS Negl Trop Dis. 10 de mayo de 2022;16(5):e0010392.
dc.relation.references138. Rabaza A, Fraga M, Corbellini LG, Turner KME, Riet-Correa F, Eisler MC. Molecular prevalence of Coxiella burnetii in bulk-tank milk from bovine dairy herds: Systematic review and meta-analysis. One Health. 1 de junio de 2021;12:100208.
dc.relation.references139. Guatteo R, Beaudeau F, Berri M, Rodolakis A, Joly A, Seegers H. Shedding routes of Coxiella burnetii in dairy cows: implications for detection and control. Vet Res. 2006;37(6):827.
dc.relation.references140. Agerholm JS. Coxiella burnetii associated reproductive disorders in domestic animals-a critical review. Acta Vet Scand. 18 de febrero de 2013;55(1):13.
dc.relation.references141. Radinović M, Davidov I, Kovačević Z, Erdeljan M, Pajić M, Galfi A. Transmission of Coxiella burnetii to Calves from Infected Cows. Acta Sci Vet [Internet]. 1 de enero de 2019 [citado 29 de enero de 2023];47.
dc.relation.references142. Brom RV den, Engelen E van, Roest HIJ, Hoek W van der, Vellema P. Coxiella burnetii infections in sheep or goats: an opinionated review. Vet Microbiol. diciembre de 2015;181(1-2):119-29.
dc.relation.references143. Oporto B, Barandika J f., Hurtado A, Aduriz G, Moreno B, Garcia-Perez A l. Incidence of Ovine Abortion by Coxiella burnetii in Northern Spain. Ann N Y Acad Sci. 2006;1078(1):498-501.
dc.relation.references144. Bouvery N, Souriau A, Lechopier P, Rodolakis A. Experimental Coxiella burnetii infection in pregnant goats: excretion routes. Vet Res. 2003;34(4):423-33.
dc.relation.references145. Roest HJ, Gelderen B van, Dinkla A, Frangoulidis D, Zijderveld F van, Rebel J, et al. Q Fever in Pregnant Goats: Pathogenesis and Excretion of Coxiella burnetii. PLOS ONE. 9 de noviembre de 2012;7(11):e48949.
dc.relation.references146. Rodolakis A, Berri M, Héchard C, Caudron C, Souriau A, Bodier CC, et al. Comparison of Coxiella burnetii Shedding in Milk of Dairy Bovine, Caprine, and Ovine Herds. J Dairy Sci. 1 de diciembre de 2007;90(12):5352-60.
dc.relation.references147. Tissot-Dupont H, Vaillant V, Rey S, Raoult D. Role of Sex, Age, Previous Valve Lesion, and Pregnancy in the Clinical Expression and Outcome of Q Fever after a Large Outbreak. Clin Infect Dis. 15 de enero de 2007;44(2):232-7.
dc.relation.references148. Maurin M, Raoult D. Q Fever. Clin Microbiol Rev. octubre de 1999;12(4):518-53.
dc.relation.references149. Terheggen U, Leggat PA. Clinical manifestations of Q fever in adults and children. Travel Med Infect Dis. 1 de mayo de 2007;5(3):159-64.
dc.relation.references150. Biecker A, Bitzer M, Biecker E. Q Fever Pneumonia in Southwest Germany: Radiographic and Clinical Findings. RöFo - Fortschritte Auf Dem Geb Röntgenstrahlen Bildgeb Verfahr. 21 de diciembre de 2016;189:146-51.
dc.relation.references151. von Ranke FM, Clemente Pessoa FM, Afonso FB, Gomes JB, Borghi DP, Alves de Melo AS, et al. Acute Q fever pneumonia: high-resolution computed tomographic findings in six patients. Br J Radiol. 1 de marzo de 2019;92(1095):20180292.
dc.relation.references152. Palmela C, Badura R, Valadas E. Acute Q fever in Portugal. Epidemiological and clinical features of 32 hospitalized patients. Germs. 1 de junio de 2012;2(2):43-59
dc.relation.references153. Voloudaki AE, Kofteridis DP, Tritou IN, Gourtsoyiannis NC, Tselentis YJ, Gikas AI. Q Fever Pneumonia: CT Findings. Radiology. junio de 2000;215(3):880-3.
dc.relation.references154. Wielders CCH, Wuister AMH, Visser VL de, Jager-Leclercq MG de, Groot CAR, Dijkstra F, et al. Characteristics of Hospitalized Acute Q Fever Patients during a Large Epidemic, The Netherlands. PLOS ONE. 10 de marzo de 2014;9(3):e91764.
dc.relation.references155. Epelboin L, Chesnais C, Boullé C, Drogoul AS, Raoult D, Djossou F, et al. Q Fever Pneumonia in French Guiana: Prevalence, Risk Factors, and Prognostic Score. Clin Infect Dis. 1 de julio de 2012;55(1):67-74.
dc.relation.references156. Rice PS, Kudesia G, McKendrick MW, Cullen DR. Coxiella burnetii serology in granulomatous hepatitis. J Infect. 1 de julio de 1993;27(1):63-6.
dc.relation.references157. Chang K, Yan JJ, Lee HC, Liu KH, Lee NY, Ko WC. Acute hepatitis with or without jaundice: a predominant presentation of acute Q fever in southern Taiwan. J Microbiol Immunol Infect Wei Mian Yu Gan Ran Za Zhi. 1 de abril de 2004;37(2):103-8.
dc.relation.references158. Lee M, Jang JJ, Kim YS, Lee SO, Choi SH, Kim SH, et al. Clinicopathologic Features of Q Fever Patients with Acute Hepatitis. Korean J Pathol. febrero de 2012;46(1):10-4.
dc.relation.references159. Hammami R, Bahloul A, Charfeddine S, Feki W, Ayed NB, Abid L, et al. Q fever presenting as myocarditis. IDCases. 1 de enero de 2021;23:e01056.
dc.relation.references160. Ohguchi H, Hirabayashi Y, Kodera T, Ishii T, Munakata Y, Sasaki T. Q Fever with Clinical Features Resembling Systemic Lupus Erythematosus. Intern Med. 2006;45(5):323-6.
dc.relation.references161. Million M, Thuny F, Bardin N, Angelakis E, Edouard S, Bessis S, et al. Antiphospholipid Antibody Syndrome With Valvular Vegetations in Acute Q Fever. Clin Infect Dis. 1 de marzo de 2016;62(5):537-44.
dc.relation.references162. Yılmaz G, Öztürk B, Memikoğlu O, Coşkun B, Yalçı A, Metin Ö, et al. An Unusual Manifestation of Q Fever: Peritonitis. J Infect Public Health. 1 de julio de 2015;8(4):373-6.
dc.relation.references163. Korkmaz S, Elaldi N, Kayatas M, Sencan M, Yildiz E. Unusual manifestations of acute Q fever: autoimmune hemolytic anemia and tubulointerstitial nephritis. Ann Clin Microbiol Antimicrob. 18 de mayo de 2012;11(1):14.
dc.relation.references164. Baziaka F, Karaiskos I, Galani L, Barmpouti E, Konstantinidis S, Kitas G, et al. Large vessel vasculitis in a patient with acute Q-fever: A case report. IDCases. 1 de enero de 2014;1(3):56-9.
dc.relation.references165. Schattner A, Bar I, Sandbank J, Adi M. An unusual presentation of acute Q fever. QJM Int J Med. 1 de marzo de 2016;109(3):199-200.
dc.relation.references166. Landais C, Fenollar F, Thuny F, Raoult D. From Acute Q Fever to Endocarditis: Serological Follow-Up Strategy. Clin Infect Dis. 15 de mayo de 2007;44(10):1337-40.
dc.relation.references167. Raoult D, Marrie T, Mege J. Natural history and pathophysiology of Q fever. Lancet Infect Dis. 1 de abril de 2005;5(4):219-26
dc.relation.references168. Jaltotage B, Ali U, Dorai-Raj A, Rankin J, Sanfilippo F, Dwivedi G. Q Fever Endocarditis: A Review of Local and all Reported Cases in the Literature. Heart Lung Circ. 1 de octubre de 2021;30(10):1509-15.
dc.relation.references169. Lepidi H, Houpikian P, Liang Z, Raoult D. Cardiac Valves in Patients with Q Fever Endocarditis: Microbiological, Molecular, and Histologic Studies. J Infect Dis. 1 de abril de 2003;187(7):1097-106.
dc.relation.references170. Wiley Z, Reddy S, Jacobs Slifka KM, Brandon DC, Jernigan J, Kersh GJ, et al. Chronic Q Fever with Vascular Involvement: Progressive Abdominal Pain in a Patient with Aortic Aneurysm Repair in the United States. Case Rep Infect Dis. 2019;2019(1):5369707.
dc.relation.references171. Botelho-Nevers E, Fournier PE, Richet H, Fenollar F, Lepidi H, Foucault C, et al. Coxiella burnetii infection of aortic aneurysms or vascular grafts: report of 30 new cases and evaluation of outcome. Eur J Clin Microbiol Infect Dis. 1 de septiembre de 2007;26(9):635-40.
dc.relation.references172. Kouijzer IJE, Kampschreur LM, Wever PC, Hoekstra C, Kasteren MEE van, Jager-Leclercq MGL de, et al. The Value of 18F-FDG PET/CT in Diagnosis and During Follow-up in 273 Patients with Chronic Q Fever. J Nucl Med. 1 de enero de 2018;59(1):127-33.
dc.relation.references173. Raoult D, Tissot-Dupont H, Foucault C, Gouvernet J, Fournier PE, Bernit E, et al. Q Fever 1985-1998: Clinical and Epidemiologic Features of 1,383 Infections. Medicine (Baltimore). marzo de 2000;79(2):109.
dc.relation.references174. Francis JR, Robson J, Wong D, Walsh M, Astori I, Gill D, et al. Chronic Recurrent Multifocal Q Fever Osteomyelitis in Children. Pediatr Infect Dis J. 1 de septiembre de 2016;35(9):972-6.
dc.relation.references175. Angelakis E, Edouard S, Lafranchi MA, Pham T, Lafforgue P, Raoult D. Emergence of Q Fever Arthritis in France. J Clin Microbiol. 21 de diciembre de 2020;52(4):1064-7.
dc.relation.references176. Eldin C, Melenotte C, Million M, Cammilleri S, Sotto A, Elsendoorn A, et al. 18F-FDG PET/CT as a central tool in the shift from chronic Q fever to Coxiella burnetii persistent focalized infection: A consecutive case series. Medicine (Baltimore). agosto de 2016;95(34):e4287.
dc.relation.references177. Million M, Bellevegue L, Labussiere AS, Dekel M, Ferry T, Deroche P, et al. Culture-negative Prosthetic Joint Arthritis Related to Coxiella burnetii. Am J Med. 1 de agosto de 2014;127(8):786.e7-786.e10.
dc.relation.references178. Landais C, Fenollar F, Constantin A, Cazorla C, Guilyardi C, Lepidi H, et al. Q fever osteoarticular infection: four new cases and a review of the literature. Eur J Clin Microbiol Infect Dis. 1 de mayo de 2007;26(5):341-7.
dc.relation.references179. Morroy G, Keijmel SP, Delsing CE, Bleijenberg G, Langendam M, Timen A, et al. Fatigue following Acute Q-Fever: A Systematic Literature Review. PLOS ONE. 25 de mayo de 2016;11(5):e0155884.
dc.relation.references180. Ankert J, Frosinski J, Weis S, Boden K, Pletz MW. Incidence of chronic Q fever and chronic fatigue syndrome: A 6 year follow-up of a large Q fever outbreak. Transbound Emerg Dis. 2022;69(4):2219-26.
dc.relation.references181. Melenotte C, Million M, Audoly G, Gorse A, Dutronc H, Roland G, et al. B-cell non-Hodgkin lymphoma linked to Coxiella burnetii. Blood. 7 de enero de 2016;127(1):113-21.
dc.relation.references182. Melenotte C, Protopopescu C, Million M, Edouard S, Carrieri MP, Eldin C, et al. Clinical Features and Complications of Coxiella burnetii Infections From the French National Reference Center for Q Fever. JAMA Netw Open. 24 de agosto de 2018;1(4):e181580.
dc.relation.references183. Eitan K, Howard A, Danny A. Q Fever in Pregnancy—Case Presentation and Literature Review. Int J Clin Med. 25 de julio de 2013;4(8):364-8.
dc.relation.references184. Million M, Roblot F, Carles D, D’Amato F, Protopopescu C, Carrieri MP, et al. Reevaluation of the Risk of Fetal Death and Malformation After Q Fever. Clin Infect Dis. 15 de julio de 2014;59(2):256-60
dc.relation.references185. Coste Mazeau P, Hantz S, Eyraud JL, Donadel L, Lacorre A, Rogez S, et al. Q fever and pregnancy: experience from the Limoges Regional University Hospital. Arch Gynecol Obstet. 1 de agosto de 2016;294(2):233-8.
dc.relation.references186. Jansen AFM, Raijmakers RPH, Keijmel SP, van der Molen RG, Vervoort GM, van der Meer JWM, et al. Autoimmunity and B-cell dyscrasia in acute and chronic Q fever: A review of the literature. Eur J Intern Med. 2018;54:6-12.
dc.relation.references187. Sahu R, Yadav JP, Vergis J, Rawool DB, Malik SVS, Barbuddhe SB. Coxiella and Q fever. En: Tang YW, Hindiyeh MY, Liu D, Sails A, Spearman P, Zhang JR, editores. Molecular Medical Microbiology (Third Edition) [Internet]. Academic Press; 2024 [citado 19 de abril de 2024]. p. 1811-47.
dc.relation.references188. Pellegrin M, Delsol G, Auvergnat JC, Familiades J, Faure H, Guiu M, et al. Granulomatous hepatitis in Q fever. Hum Pathol. 1980;11(1):51-7.
dc.relation.references189. Honstettre A, Ghigo E, Moynault A, Capo C, Toman R, Akira S, et al. Lipopolysaccharide from Coxiella burnetii Is Involved in Bacterial Phagocytosis, Filamentous Actin Reorganization, and Inflammatory Responses through Toll-Like Receptor 41. J Immunol. 2004;172(6):3695-703.
dc.relation.references190. Matthiesen S, Zaeck L, Franzke K, Jahnke R, Fricke C, Mauermeir M, et al. Coxiella burnetii-Infected NK Cells Release Infectious Bacteria by Degranulation. Infect Immun. 2020;88(11):10.1128/iai.00172-20.
dc.relation.references191. Ka MB, Bechah Y, Olive D, Mege JL. Programmed death ligand-1 expression and memory T-cell generation in Coxiella burnetii infection. Microb Pathog. 2015;80:1-6.
dc.relation.references192. Marmion BP, Ormsbee RA, Kyrkou M, Wright J, Worswick DA, Izzo AA, et al. Vaccine prophylaxis of abattoir-associated Q fever: eight years’ experience in Australian abattoirs. Epidemiol Infect. 1990;104(2):275-87.
dc.relation.references193. Sahu R, Rawool DB, Vinod VK, Malik SVS, Barbuddhe SB. Current approaches for the detection of Coxiella burnetii infection in humans and animals. J Microbiol Methods. 2020;179:106087.
dc.relation.references194. Miller HK, Priestley RA, Kersh GJ. Q Fever: A Troubling Disease and a Challenging Diagnosis. Clin Microbiol Newsl. 2021;43(13):109-18.
dc.relation.references195. Meekelenkamp JCE, Schneeberger PM, Wever PC, Leenders ACAP. Comparison of ELISA and indirect immunofluorescent antibody assay detecting Coxiella burnetii IgM phase II for the diagnosis of acute Q fever. Eur J Clin Microbiol Infect Dis. 2012;31(6):1267-70.
dc.relation.references196. Kumar M, Malik SS, Vergis J, Ramanjeneya S, Sahu R, Pathak R, et al. Development of the Com1 synthetic peptide-based Latex Agglutination Test (LAT) and its comparative evaluation with commercial indirect-ELISA for sero-screening of coxiellosis in cattle. J Microbiol Methods;162:83-5
dc.relation.references197. Herremans T, Hogema BM, Nabuurs M, Peeters M, Wegdam-Blans M, Schneeberger P, et al. Comparison of the performance of IFA, CFA, and ELISA assays for the serodiagnosis of acute Q fever by quality assessment. Diagn Microbiol Infect Dis. 2013;75(1):16-21.
dc.relation.references198. Woc-Colburn AM, Garner MM, Bradway D, West G, D’Agostino J, Trupkiewicz J, et al. Fatal Coxiellosis in Swainson’s Blue Mountain Rainbow Lorikeets (Trichoglossus haematodus moluccanus). Vet Pathol. 2008;45(2):247-54.
dc.relation.references199. Bildfell RJ, Thomson GW, Haines DM, McEwen BJ, Smart N. Coxiella Burnetii Infection is Associated with Placentitis in Cases of Bovine Abortion. J Vet Diagn Invest. 1 de septiembre de 2000;12(5):419-25.
dc.relation.references200. Lockhart MG, Islam A, Fenwick SG, Graves SR, Stenos J. Comparative sensitivity of four different cell lines for the isolation of Coxiella burnetii. FEMS Microbiol Lett. 1 de septiembre de 2012;334(2):75-8.
dc.relation.references201. Omsland A, Cockrell DC, Howe D, Fischer ER, Virtaneva K, Sturdevant DE, et al. Host cell-free growth of the Q fever bacterium Coxiella burnetii. Proc Natl Acad Sci. 17 de marzo de 2009;106(11):4430-4.
dc.relation.references202. Klee SR, Tyczka J, Ellerbrok H, Franz T, Linke S, Baljer G, et al. Highly sensitive real-time PCR for specific detection and quantification of Coxiella burnetii. BMC Microbiol. 19 de enero de 2006;6(1):2.
dc.relation.references203. Sidi-Boumedine K, Duquesne V, Prigent M, Yang E, Joulié A, Thiéry R, et al. Impact of IS1111 insertion on the MLVA genotyping of Coxiella burnetii. Microbes Infect. 1 de noviembre de 2015;17(11):789-94.
dc.relation.references204. Melenotte C, Million M, Raoult D. New insights in Coxiella burnetii infection: diagnosis and therapeutic update. Expert Rev Anti Infect Ther. 2 de enero de 2020;18(1):75-86.
dc.relation.references205. Million M, Walter G, Thuny F, Habib G, Raoult D. Evolution From Acute Q Fever to Endocarditis Is Associated With Underlying Valvulopathy and Age and Can Be Prevented by Prolonged Antibiotic Treatment. Clin Infect Dis. 15 de septiembre de 2013;57(6):836-44.
dc.relation.references206. Ghanem-Zoubi N, Paul M, Szwarcwort M, Agmon Y, Kerner A. Screening for Q Fever in Patients Undergoing Transcatheter Aortic Valve Implantation, Israel, June 2018–May 2020. Emerg Infect Dis. agosto de 2021;27(8):2205.
dc.relation.references207. Plummer PJ, McClure JT, Menzies P, Morley PS, Van den Brom R, Van Metre DC. Management of oxiella burnetii infection in livestock populations and the associated zoonotic risk: A consensus statement. J Vet Intern Med. 2018;32(5):1481-94.
dc.relation.references208. Ruiz S, Wolfe DN. Vaccination against Q fever for biodefense and public health indications. Front Microbiol [Internet]. 16 de diciembre de 2014 [citado 4 de noviembre de 2024];5.
dc.relation.references209. Long CM. Q Fever Vaccine Development: Current Strategies and Future Considerations. Pathogens. octubre de 2021;10(10):1223.
dc.relation.references210. Anderson A, Bijlmer H, Fournier PE, Graves S, Hartzell J, Kersh GJ, et al. Diagnosis and Management of Q Fever — United States, 2013: Recommendations from CDC and the Q Fever Working Group. Morb Mortal Wkly Rep Recomm Rep. 2013;62(3):1-29.
dc.relation.references211. Instituto Colombiano Agropecuario - ICA [Internet]. [citado 27 de enero de 2025]. Disponible en: https://www.ica.gov.co/areas/pecuaria/servicios/epidemiologia-veterinaria/censos-2016/censo-2018
dc.relation.references212. Cameron AR, Baldock FC. Two-stage sampling in surveys to substantiate freedom from disease. Prev Vet Med. 6 de febrero de 1998;34(1):19-30.
dc.relation.references213. Cortés JA, Romero-Moreno LF, Aguirre-León CA, Pinzón-Lozano L, Cuervo SI, Cortés JA, et al. Enfoque clínico del síndrome febril agudo en Colombia. Infectio. enero de 2017;21(1):39-50.
dc.relation.references214. Li JS, Sexton DJ, Mick N, Nettles R, Fowler VG Jr, Ryan T, et al. Proposed Modifications to the Duke Criteria for the Diagnosis of Infective Endocarditis. Clin Infect Dis. 2000;30(4):633-8.
dc.relation.references215. de Miguel IM, Martínez-Sellés M. Miocarditis (I). Med - Programa Form Médica Contin Acreditado. 2017;12(43):2535-47.
dc.relation.references216. Sagar S, Liu PP, Cooper LT. Myocarditis. The Lancet. 25 de febrero de 2012;379(9817):738-47.
dc.relation.references217. Berri M, Laroucau K, Rodolakis A. The detection of Coxiella burnetii from ovine genital swabs, milk and fecal samples by the use of a single touchdown polymerase chain reaction. Vet Microbiol. 2000;72(3):285-93.
dc.relation.references218. Palomar AM, Molina I, Bocanegra C, Portillo A, Salvador F, Moreno M, et al. Old zoonotic agents and novel variants of tick-borne microorganisms from Benguela (Angola), July 2017. Parasit Vectors. 2022;15(1):140.
dc.relation.references219. Katoh K, Misawa K, Kuma K, Miyata T. MAFFT: a novel method for rapid multiple sequence alignment based on fast Fourier transform. Nucleic Acids Res. 15 de julio de 2002;30(14):3059-66.
dc.relation.references220. Nguyen LT, Schmidt HA, von Haeseler A, Minh BQ. IQ-TREE: A Fast and Effective Stochastic Algorithm for Estimating Maximum-Likelihood Phylogenies. Mol Biol Evol. 1 de enero de 2015;32(1):268-74.
dc.relation.references221. Letunic I, Bork P. Interactive Tree Of Life (iTOL) v5: an online tool for phylogenetic tree display and annotation. Nucleic Acids Res. 2 de julio de 2021;49(W1):W293-6.
dc.relation.references222. Yuan S, Chan HCS, Filipek S, Vogel H. PyMOL and Inkscape Bridge the Data and the Data Visualization. Structure. 6 de diciembre de 2016;24(12):2041-2.
dc.relation.references223. WMA - The World Medical Association-Declaración de Helsinki de la AMM – Principios éticos para las investigaciones médicas con participantes humanos [Internet]. [citado 27 de enero de 2025].
dc.relation.references224. docs_DerechosAnimales-.pdf [Internet]. [citado 12 de febrero de 2025]
dc.relation.references225. Duron O, Noël V, McCoy KD, Bonazzi M, Sidi-Boumedine K, Morel O, et al. The Recent Evolution of a Maternally-Inherited Endosymbiont of Ticks Led to the Emergence of the Q Fever Pathogen, Coxiella burnetii. PLOS Pathog. 2015;11(5):e1004892.
dc.relation.references226. Szymańska-Czerwińska M, Jodełko A, Zaręba-Marchewka K, Niemczuk K. Shedding and genetic diversity of Coxiella burnetii in Polish dairy cattle. PLOS ONE. 2019;14(1):e0210244.
dc.relation.references227. Tomaiuolo S, Boarbi S, Fancello T, Michel P, Desqueper D, Grégoire F, et al. Phylogeography of Human and Animal Coxiella burnetii Strains: Genetic Fingerprinting of Q Fever in Belgium. Front Cell Infect Microbiol [Internet]. 2021
dc.relation.references228. Grantina-IevinaGrantiņa-Ieviņa L, SteingoldeŠteingolde Ž, Boikmanis G, LaizaneLaizāne L, Ringa-OslejaRinga-Ošleja G, Bubula I, et al. Shedding of Coxiella burnetii in milk of dairy cattle and evidence of Q-fever in domestic ruminants with emphasis on abortion cases in Latvia
dc.relation.references229. Mohabati Mobarez A, Baseri N, Khalili M, Mostafavi E, Stenos J, Esmaeili S. Genetic Diversity of Coxiella burnetii in Iran by Multi-Spacer Sequence Typing. Pathogens. 2022;11(10):1175.
dc.relation.references230. Truong AT, Youn SY, Yoo MS, Lim JY, Yoon SS, Cho YS. Genotyping of Coxiella burnetii from Cattle by Multispacer Sequence Typing and Multiple Locus Variable Number of Tandem Repeat Analysis in the Republic of Korea. Genes. 2022;13(11):1927.
dc.relation.references231. Astobiza I, Tilburg JJ, Piñero A, Hurtado A, García-Pérez AL, Nabuurs-Franssen MH, et al. Genotyping of Coxiella burnetiifrom domestic ruminants in northern Spain. BMC Vet Res. 10 de diciembre de 2012;8(1):241.
dc.relation.references232. Hornstra HM, Priestley RA, Georgia SM, Kachur S, Birdsell DN, Hilsabeck R, et al. Rapid Typing of Coxiella burnetii. PLOS ONE.2011;6(11):e26201.
dc.relation.references233. Tilburg JJHC, Roest HJIJ, Buffet S, Nabuurs-Franssen MH, Horrevorts AM, Raoult D, et al. Epidemic Genotype of Coxiella burnetii among Goats, Sheep, and Humans in the Netherlands. Emerg Infect Dis. 2012;18(5):887-9
dc.relation.references234. Priestley RA, Smith CB, Miller HK, Kersh GJ. Coxiella burnetii infections in mice: Immunological responses to contemporary genotypes found in the US. Virulence. 2021;12(1):2461-73.
dc.relation.references235. Frangoulidis D, Walter MC, Antwerpen M, Zimmermann P, Janowetz B, Alex M, et al. Molecular analysis of Coxiella burnetii in Germany reveals evolution of unique clonal clusters. Int J Med Microbiol. 2014;304(7):868-76.
dc.relation.references236. Chmielewski T, Tylewska-Wierzbanowska S. Q fever outbreaks in Poland during 2005–2011. Med Sci Monit Int Med J Exp Clin Res. 2013;19:1073-9
dc.relation.references237. Van Leuken JPG, Swart AN, Brandsma J, Terink W, Van de Kassteele J, Droogers P, et al. Human Q fever incidence is associated to spatiotemporal environmental conditions. One Health. 2016;2:77-87.
dc.relation.references238. Máttar S, Parra M. Detección de anticuerpos contra Anaplasma, Bartonella and Coxiella en habitantes rurales de un área del caribe colombiano. Rev MVZ Córdoba [Internet]. 2006;11(2).
dc.relation.references239. Contreras V, Máttar S, González M, Álvarez J, Oteo JA. Coxiella burnetii in bulk tank milk and antibodies in farm workers at Montería, Colombia. Rev Colomb Cienc Pecu. 2015;28(2):181-7.
dc.relation.references240. Anastácio S, Carolino N, Sidi-Boumedine K, da Silva GJ. Q Fever Dairy Herd Status Determination Based on Serological and Molecular Analysis of Bulk Tank Milk. Transbound Emerg Dis. 2016;63(2):e293-300.
dc.relation.references241. Astobiza I, Ruiz-Fons F, Piñero A, Barandika JF, Hurtado A, García-Pérez AL. Estimation of Coxiella burnetii prevalence in dairy cattle in intensive systems by serological and molecular analyses of bulk-tank milk samples. J Dairy Sci. 2012;95(4):1632-8.
dc.relation.references242. Muskens J, van Engelen E, van Maanen C, Bartels C, Lam TJGM. Prevalence of Coxiella burnetii infection in Dutch dairy herds based on testing bulk tank milk and individual samples by PCR and ELISA. Vet Rec. 2011;168(3):79-79
dc.relation.references243. Valkovska L, Mališevs A, Kovaļenko K, Bērziņš A, Grantiņa-Ieviņa L. Coxiella Burnetii DNA in Milk, Milk Products, and Fermented Dairy Products. J Vet Res. 20 de octubre de 2021;65(4):441.
dc.relation.references244. Barandika JF, Alvarez-Alonso R, Jado I, Hurtado A, García-Pérez AL. Viable Coxiella burnetii in hard cheeses made with unpasteurized milk. Int J Food Microbiol. 16 de agosto de 2019;303:42-5.
dc.relation.references245. Miller HK, Priestley RA, Kersh GJ. Transmission of Coxiella burnetii by ingestion in mice. Epidemiol Infect. enero de 2020;148:e21.
dc.relation.references246. Guatteo R, Beaudeau F, Joly A, Seegers H. Coxiella burnetii shedding by dairy cows. Vet Res. 2007;38(6):849.
dc.relation.references247. Barlow J, Rauch B, Welcome F, Kim S, Dubovi E, Schukken Y. Association between Coxiella burnetii shedding in milk and subclinical mastitis in dairy cattle. Vet Res. 2008;39(3):1.
dc.relation.references248. Rabaza A, Macías-Rioseco M, Fraga M, Uzal FA, Eisler MC, Riet-Correa F, et al. Coxiella burnetii abortion in a dairy farm selling artisanal cheese directly to consumers and review of Q fever as a bovine abortifacient in South America and a human milk-borne disease. Braz J Microbiol. 2021;52(4):2511-20.
dc.relation.references249. Corbellini LG, Pescador CA, Frantz F, Wunder E, Steffen D, Smith DR, et al. Diagnostic survey of bovine abortion with special reference to Neospora caninum infection: Importance, repeated abortion and concurrent infection in aborted fetuses in Southern Brazil. Vet J. 2006;172(1):114-20.
dc.relation.references250. Campero CM, Moore DP, Odeón AC, Cipolla AL, Odriozola E. Aetiology of Bovine Abortion in Argentina. Vet Res Commun. 2003;27(5):359-69.
dc.relation.references251. Morrell E. Caracterización diagnóstica de las causas infecciosas del aborto bovino [Internet] [Tesis]. Universidad Nacional de La Plata; 2010 [citado 5 de noviembre de 2024]. Disponible en: http://sedici.unlp.edu.ar/handle/10915/1588
dc.relation.references252. Hawker J, Ayres J, Blair I, Evans M, Smith D, Smith E, et al. A large outbreak of Q fever in the West Midlands: windborne spread into a metropolitan area? Commun Dis PUBLIC Health. 1998;1(3).
dc.relation.references253. Tissot-Dupont H, Amadei MA, Nezri M, Raoult D. Wind in November, Q Fever in December. Emerg Infect Dis. 2004;10(7):1264-9.
dc.relation.references254. Nusinovici S, Hoch T, Widgren S, Joly A, Lindberg A, Beaudeau F. Relative contributions of neighbourhood and animal movements to Coxiella burnetii infection in dairy cattle herds. Geospatial Health. 1 de mayo de 2014;8(2):471-7.
dc.relation.references255. Kersh GJ, Fitzpatrick KA, Self JS, Priestley RA, Kelly AJ, Lash RR, et al. Presence and Persistence of Coxiella burnetii in the Environments of Goat Farms Associated with a Q Fever Outbreak. Appl Environ Microbiol. marzo de 2013;79(5):1697-703.
dc.relation.references256. Cabrera R, Mendoza W, López-Mosquera L, Cano MA, Ortiz N, Campo V, et al. Tick-Borne-Agents Detection in Patients with Acute Febrile Syndrome and Ticks from Magdalena Medio, Colombia. Pathogens. octubre de 2022;11(10):1090.
dc.relation.references257. Cardona JCM. Neumonía por Coxiella burnetii: presentación de un caso y revisión de la literatura / Coxiella burnetii pneumonia: Case report and literature review. CES Med. 14 de diciembre de 2012;26(2):201-8.
dc.relation.references258. Caforio ALP, Pankuweit S, Arbustini E, Basso C, Gimeno-Blanes J, Felix SB, et al. Current state of knowledge on aetiology, diagnosis, management, and therapy of myocarditis: a position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases. Eur Heart J. 1 de septiembre de 2013;34(33):2636-48.
dc.relation.references259. Thomas Aretz H. Myocarditis: The Dallas criteria. Hum Pathol. 1 de junio de 1987;18(6):619-24
dc.relation.references260. Elliott P, Andersson B, Arbustini E, Bilinska Z, Cecchi F, Charron P, et al. Classification of the cardiomyopathies: a position statement from the european society of cardiology working group on myocardial and pericardial diseases. Eur Heart J. 1 de enero de 2008;29(2):270-6.
dc.relation.references261. Sathirareuangchai S, Armstrong S. The pathology of pericarditis. Diagn Histopathol. 2022;28(4):191-8.
dc.relation.references262. Imazio M, Brucato A, Cemin R, Ferrua S, Maggiolini S, Beqaraj F, et al. A Randomized Trial of Colchicine for Acute Pericarditis. N Engl J Med. 2013;369(16):1522-8.
dc.rightsCopyright Universidad de Córdoba, 2025
dc.rights.accessrightsinfo:eu-repo/semantics/embargoedAccess
dc.rights.coarhttp://purl.org/coar/access_right/c_f1cf
dc.rights.licenseAtribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.keywordsQ fever
dc.subject.keywordsZoonoses
dc.subject.keywordsCoxiella burnetii
dc.subject.keywordsGenotypes
dc.subject.keywordsRuminants
dc.subject.keywordsMolecular epidemiology
dc.subject.keywordsColombia
dc.subject.proposalFiebre Q
dc.subject.proposalZoonosis
dc.subject.proposalCoxiella burnetii
dc.subject.proposalGenotipos
dc.subject.proposalRumiantes
dc.subject.proposalEpidemiología molecular
dc.subject.proposalColombia
dc.titleEstudio sobre Coxiella burnetii en Córdoba: genotipificación y distribución espacial en rumiantes domésticos y humanosspa
dc.typeTrabajo de grado - Doctorado
dc.type.coarhttp://purl.org/coar/resource_type/c_db06
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.driverinfo:eu-repo/semantics/doctoralThesis
dc.type.redcolhttp://purl.org/redcol/resource_type/TD
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dspace.entity.typePublication
Archivos
Bloque original
Mostrando 1 - 2 de 2
No hay miniatura disponible
Nombre:
Tesis doctoral - Estudio sobre Coxiella burnetii - Verónica contreras 18-07-25.pdf
Tamaño:
4.57 MB
Formato:
Adobe Portable Document Format
Descargar
No hay miniatura disponible
Nombre:
AutorizaciónPublicación _22-07-25.pdf
Tamaño:
383.35 KB
Formato:
Adobe Portable Document Format
Descargar
Bloque de licencias
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
license.txt
Tamaño:
15.18 KB
Formato:
Item-specific license agreed upon to submission
Descripción:
Descargar
Colecciones
G.F.A. Tesis