Publicación:
Vigilancia de coronavirus en murciélagos del departamento de Córdoba- Colombia

Vista sencilla de ítem
dc.contributor.advisorCalderón Rangel, Alfonso
dc.contributor.authorMartínez Bravo, Caty Milena
dc.contributor.educationalvalidatorSalim Mattar
dc.contributor.juryMantilla-Meluk, Hugo
dc.contributor.jurySampedro, Alcides Casimiro
dc.contributor.juryRuíz-Saenz, Julián
dc.date.accessioned2025-08-01T16:02:55Z
dc.date.available2026-07-31
dc.date.available2025-08-01T16:02:55Z
dc.date.issued2025-07-31
dc.description.abstractIntroducción. Los murciélagos desempeñan funciones ecológicas esenciales y han sido identificados como reservorios naturales de virus. La creciente pérdida de hábitats puede favorecer la interacción entre murciélagos, animales domésticos y humanos, facilitando las zoonosis. Objetivo. Implementar una vigilancia de coronavirus en murciélagos del departamento de Córdoba. Materiales y Métodos. Entre 2022 y 2023, se realizó una vigilancia epidemiológica en once municipios del departamento de Córdoba. Se capturaron murciélagos mediante un muestreo no probabilístico, a través de redes de niebla. Se realizaron pruebas serológicas para detección de anticuerpos. Las muestras positivas por PCR anidada dirigida al gen RdRp de coronavirus, fueron secuenciadas mediante los métodos Sanger y NGS. Se realizaron análisis filogenéticos y estructurales con herramientas bioinformáticas. Se ejecutaron estrategias de apropiación social del conocimiento y actividades de divulgación en redes sociales. Resultados. Se capturaron 262 murciélagos. La serología reveló anticuerpos contra la proteína N en cinco individuos (2,7%). La PCR detectó el gen RdRp de coronavirus en 55 (21,0 %) murciélagos pertenecientes a Alfacoronavirus. Se halló un Alphacoronavirus por NGS en Phyllostomus hastatus. El análisis de la proteína S y del dominio de unión al receptor (RBD) reveló homología con HCoV-229E y TEGV porcino, lo que sugiere un posible riesgo de salto inter-especie. Las estrategias de divulgación permitieron transformar de manera positiva las percepciones en las comunidades locales, facilitando el enfoque One Health. Conclusiones. Los hallazgos confirman la circulación de coronavirus en poblaciones de murciélagos del departamento de Córdoba, y aportan evidencia científica sobre la diversidad viral y su potencial zoonótico en Colombia.spa
dc.description.degreelevelDoctorado
dc.description.degreenameDoctor(a) en Microbiología y Salud Tropical
dc.description.modalityTrabajos de Investigación y/o Extensión
dc.description.tableofcontentsRESUMEN ………………………………………………………………………..…………………………………….10spa
dc.description.tableofcontentsABSTRACT ………………………………………………………………..………………………………………..….12eng
dc.description.tableofcontentsINTRODUCCIÓN …………………………………………………………………………………………………..…14spa
dc.description.tableofcontentsOBJETIVOS ………………………………………………………………………………………..…………………..18spa
dc.description.tableofcontentsGeneral …………………………………………………………….…………………………………………….…… 18spa
dc.description.tableofcontentsEspecíficos …………………………………………………………………………………………………….……. 18spa
dc.description.tableofcontentsMETODOLOGÍA …………………………………………………………………………………………………….. 19spa
dc.description.tableofcontentsTipo de estudio ……………………………………………………………………………………………………. 19spa
dc.description.tableofcontentsÁrea de estudio. ……………………………………………………………………………………………………19spa
dc.description.tableofcontentsAspectos éticos. …………………………………………………………………………………………………… 20spa
dc.description.tableofcontentsTamaño de la muestra …………………………………………………………………………………………..20spa
dc.description.tableofcontentsMétodos de campo. ……………………………………………………………………………………………….21spa
dc.description.tableofcontentsLugares de captura. ……………………………………….22spa
dc.description.tableofcontentsMétodos serológicos ……………………………………….….23spa
dc.description.tableofcontentsMétodos moleculares …………………………………….….23spa
dc.description.tableofcontentsMétodos de secuenciación …………………………….….23spa
dc.description.tableofcontentsMétodos de apropiación social del conocimiento …………..25spa
dc.description.tableofcontentsRESULTADOS Objetivo 1. Bats from an area of the Colombian Caribbean reveal the circulation of Alphacoronavirus ……….26eng
dc.description.tableofcontentsAbstract ……………………………........………… 27eng
dc.description.tableofcontentsIntroduction ……………………………..………………… 27eng
dc.description.tableofcontentsMaterials and methods …………..……………………. 28eng
dc.description.tableofcontentsResults ………………………………………….. 28eng
dc.description.tableofcontentsDiscussion …………………………… 30eng
dc.description.tableofcontentsConclusion …………………………………………… 32eng
dc.description.tableofcontentsCRediT authorship contribution statement …………………. 32eng
dc.description.tableofcontentsEthical approval …………..………………………… 32eng
dc.description.tableofcontentsFunding ………………………………………………………...32eng
dc.description.tableofcontentsDeclaration of competing interest………..…………………… 32eng
dc.description.tableofcontentsData availability …………………………..………………… 32eng
dc.description.tableofcontentsReferences …………………………………………… 32eng
dc.description.tableofcontentsObjetivo 2. New coronavirus in bats in the Colombian Caribbean, possible risk of interspecies jump ……. 34eng
dc.description.tableofcontentsAbstract ………………………………………..…… 35eng
dc.description.tableofcontentsIntroduction …………………………………………..… 35eng
dc.description.tableofcontentsMethods ……………………………………….………….... 36eng
dc.description.tableofcontentsResults ……………………………………………….... 37eng
dc.description.tableofcontentsDiscussion ………………………………………………….…… 42eng
dc.description.tableofcontentsFunding ………………………………………………………… 44eng
dc.description.tableofcontentsAcknowledgements …………………………………… 44eng
dc.description.tableofcontentsConflict of interest……………………………………..... 44eng
dc.description.tableofcontentsReferences …………………………………………………….….. 44eng
dc.description.tableofcontentsSupplementary Material ……………………………………..….. 47eng
dc.description.tableofcontentsObjetivo 3. Intervenciones educativas comunitarias relacionadas con vigilancia zoonótica en murciélagos del departamento de Córdoba- Colombia …… 52spa
dc.description.tableofcontentsResumen …………………………………………………… 53spa
dc.description.tableofcontentsIntroducción ……………………………………………………..54spa
dc.description.tableofcontentsMateriales y Métodos …………………………….. 55spa
dc.description.tableofcontentsResultados ………………………………………………………... 57spa
dc.description.tableofcontentsDiscusión …………………………………………………………………. 63spa
dc.description.tableofcontentsConflicto de intereses…………………………………..….. 65spa
dc.description.tableofcontentsAgradecimientos ……………………………………………………… 65spa
dc.description.tableofcontentsReferencias …………………………………………………………………….. 66spa
dc.description.tableofcontentsArchivo suplementario………………………………………………68spa
dc.description.tableofcontentsCONCLUSIONES …………………………………………………………. 72spa
dc.description.tableofcontentsRECOMENDACIONES ………………………………………………………. 73spa
dc.description.tableofcontentsREFERENCIAS BIBLIOGRAFICAS ……………………………………… 74spa
dc.description.tableofcontentsANEXOS …………………………………………………………….. 80spa
dc.format.mimetypeapplication/pdf
dc.identifier.instnameUniversidad de Córdoba
dc.identifier.reponameRepositorio Universidad de Córdoba
dc.identifier.repourlhttps://repositorio.unicordoba.edu.co/
dc.identifier.urihttps://repositorio.unicordoba.edu.co/handle/ucordoba/9521
dc.language.isospa
dc.publisherUniversidad de Córdoba
dc.publisher.facultyFacultad de Medicina Veterinaria y Zootecnia
dc.publisher.placeBerástegui, Córdoba, Colombia
dc.publisher.programDoctorado en Microbiología y Salud Tropical
dc.relation.referencesAltschul, S. F., Gish, W., Miller, W., Myers, E. W., & Lipman, D. J. (1990). Basic local alignment search tool. Journal of Molecular Biology, 215(3), 403–410. https://doi.org/10.1016/S0022-2836(05)80360-2
dc.relation.referencesAnthony, S. J., Johnson, C. K., Greig, D. J., Kramer, S., Che, X., Wells, H., Hicks, A. L., Joly, D. O., Wolfe, N. D., Daszak, P., Karesh, W., Lipkin, W. I., Morse, S. S., Mazet, J. A. K., & Goldstein, T. (2017). Global patterns in coronavirus diversity. Virus Evolution, 3(1). https://doi.org/10.1093/ve/vex012
dc.relation.referencesArtika, I. M., Dewantari, A. K., & Wiyatno, A. (2020). Molecular biology of coronaviruses: current knowledge. In Heliyon (Vol. 6, Issue 8). Elsevier Ltd. https://doi.org/10.1016/j.heliyon.2020.e04743
dc.relation.referencesAVMA. (2020). American Veterinary Medical Association guidelines for the euthanasia of animals: 2020 edition. In American Veterinary Medical Association guidelines for the euthanasia of animals: 2020 edition.
dc.relation.referencesBanerjee, A., Kulcsar, K., Misra, V., Frieman, M., & Mossman, K. (2019). Bats and coronaviruses. In Viruses (Vol. 11, Issue 1). MDPI AG. https://doi.org/10.3390/v11010041
dc.relation.referencesBenson, D. A., Karsch-Mizrachi, I., Lipman, D. J., Ostell, J., & Wheeler, D. L. (2004). GenBank: Update. Nucleic Acids Research, 32(DATABASE ISS.). https://doi.org/10.1093/nar/gkh045
dc.relation.referencesBrook, C. E., & Dobson, A. P. (2015). Bats as “special” reservoirs for emerging zoonotic pathogens. In Trends in Microbiology (Vol. 23, Issue 3, pp. 172–180). Elsevier Ltd. https://doi.org/10.1016/j.tim.2014.12.004
dc.relation.referencesBudeski, K., & Lipsitch, M. (2025). Focusing a viral risk ranking tool on prediction. Proceedings of the National Academy of Sciences of the United States of America, 122(16). https://doi.org/10.1073/pnas.2419337122
dc.relation.referencesCaiza-Villegas, A., Ginn, F., & van Hoven, B. (2024). Learning to live with synanthropic bats: Practices of tolerance and care in domestic space. Social and Cultural Geography, 25(6). https://doi.org/10.1080/14649365.2023.2209054
dc.relation.referencesCalderón, A., Guzmán, C., Mattar, S., Rodriguez, V., Martínez, C., Violet, L., Martínez, J., & Figueiredo, L. T. M. (2019). Dengue Virus in Bats from Córdoba and Sucre, Colombia. Vector-Borne and Zoonotic Diseases, 19(10), 747–751. https://doi.org/10.1089/vbz.2018.2324
dc.relation.referencesCalderón- Rangel, A., Guzmán, C., Mattar, S., Rodríguez, V., Acosta, A., & Martínez, C. (2019). Frugivorous bats in the Colombian Caribbean region are reservoirs of the rabies virus. Annals of Clinical Microbiology and Antimicrobials, 18(1). https://doi.org/10.1186/s12941-019-0308-y
dc.relation.referencesCalisher, C. H., Childs, J. E., Field, H. E., Holmes, K. V., & Schountz, T. (2006). Bats: Important reservoir hosts of emerging viruses. In Clinical Microbiology Reviews (Vol. 19, Issue 3, pp. 531–545). https://doi.org/10.1128/CMR.00017-06
dc.relation.referencesCarpenter, J. P., Morrison, S. A., Craft, M., & Lee, M. (2020). How and why are educators using Instagram? Teaching and Teacher Education, 96. https://doi.org/10.1016/j.tate.2020.103149
dc.relation.referencesChacón, J., Pacheco, C., & Ballesteros, J. (2024). Chacón, 2024. Bats Cordoba. Revista de Biología Tropical, 72(1). https://doi.org/http://dx.doi.org/10.15517/rev.biol.trop..v72i1.54761.
dc.relation.referencesChacón, J., Sánchez-Londoño, J. D., Villada-Cadavid, T., & Ballesteros-Correa, J. (2022). Update of the list of wild mammals of the department of Córdoba, Colombia. Biota Colombiana, 23(1). https://doi.org/10.21068/2539200X.966
dc.relation.referencesChen, S., Zhou, Y., Chen, Y., & Gu, J. (2018). Fastp: An ultra-fast all-in-one FASTQ preprocessor. Bioinformatics, 34(17), i884–i890. https://doi.org/10.1093/bioinformatics/bty560
dc.relation.referencesChu, D. K. W., Leung, C. Y. H., Gilbert, M., Joyner, P. H., Ng, E. M., Tse, T. M., Guan, Y., Peiris, J. S. M., & Poon, L. L. M. (2011). Avian Coronavirus in Wild Aquatic Birds. Journal of Virology, 85(23), 12815–12820. https://doi.org/10.1128/jvi.05838-11
dc.relation.referencesDi Rienzo, J. A. (2020). InfoStat, version 2020. Grupo InfoStat, FCA, Universidad Nacional de Córdoba Argentina.
dc.relation.referencesDíaz, M., Solari, S., Gregorin, R., Aguirre, L., & Barquez, R. (2021). Clave de identificación de los murciélagos neotropicales. http://hdl.handle.net/11336/156765
dc.relation.referencesEby, P., Peel, A. J., Hoegh, A., Madden, W., Giles, J. R., Hudson, P. J., & Plowright, R. K. (2023). Pathogen spillover driven by rapid changes in bat ecology. Nature, 613(7943), 340–344. https://doi.org/10.1038/s41586-022-05506-2
dc.relation.referencesEcheverri-De la Hoz, D., Martínez-Bravo, C., Gastelbondo-Pastrana, B., Rivero, R., López, Y., Bertel, V., Alemán-Santos, M., Garay, E., Hoyos, R., Arrieta, G., Ramírez, J. D., & Mattar, S. (2025). Genomics of novel influenza A virus (H18N12) in bats, Caribe Colombia. Scientific Reports, 15(1), 6507. https://doi.org/10.1038/s41598-025-91026-8
dc.relation.referencesFrick, W. F., Kingston, T., & Flanders, J. (2020). A review of the major threats and challenges to global bat conservation. In Annals of the New York Academy of Sciences (Vol. 1469, Issue 1). https://doi.org/10.1111/nyas.14045
dc.relation.referencesGBIF.org. (2024). GBIF Home Page. GBIF Secretariat, Denmark. Ge, X. Y., Li, J. L., Yang, X. Lou, Chmura, A. A., Zhu, G., Epstein, J. H., Mazet, J. K., Hu, B., Zhang, W., Peng, C., Zhang, Y. J., Luo, C. M., Tan, B., Wang, N., Zhu, Y., Crameri, G., Zhang, S. Y., Wang, L. F., Daszak, P., & Shi, Z. L. (2013). Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor. Nature, 503(7477), 535–538. https://doi.org/10.1038/nature12711
dc.relation.referencesGuzmán, C., Calderón, A., Martinez, C., Oviedo, M., & Mattar, S. (2019). Eco-epidemiology of the Venezuelan equine encephalitis virus in bats of Córdoba and Sucre, Colombia. Acta Tropica, 191, 178–184. https://doi.org/10.1016/J.ACTATROPICA.2018.12.016
dc.relation.referencesHorefti, E. (2023). The Importance of the One Health Concept in Combating Zoonoses. In Pathogens (Vol. 12, Issue 8). Multidisciplinary Digital Publishing Institute (MDPI). https://doi.org/10.3390/pathogens12080977
dc.relation.referencesHu, B., Ge, X., Wang, L. F., & Shi, Z. (2015). Bat origin of human coronaviruses Coronaviruses: Emerging and re-emerging pathogens in humans and animals Susanna Lau Positive-strand RNA viruses. In Virology Journal (Vol. 12, Issue 1). BioMed Central Ltd. https://doi.org/10.1186/s12985-015-0422-1
dc.relation.referencesHulswit, R. J. G., de Haan, C. A. M., & Bosch, B. J. (2016). Coronavirus Spike Protein and Tropism Changes. In Advances in Virus Research (Vol. 96, pp. 29–57). Academic Press Inc. https://doi.org/10.1016/bs.aivir.2016.08.004
dc.relation.referencesIrving, A. T., Ahn, M., Goh, G., Anderson, D. E., & Wang, L. F. (2021). Lessons from the host defences of bats, a unique viral reservoir. In Nature (Vol. 589, Issue 7842, pp. 363–370). Nature Research. https://doi.org/10.1038/s41586-020-03128-0
dc.relation.referencesKingston, T. (2015). Cute, creepy, or crispy—How values, attitudes, and norms shape human behavior toward bats. In Bats in the Anthropocene: Conservation of Bats in a Changing World (pp. 571–595). Springer International Publishing. https://doi.org/10.1007/978-3-319-25220-9_18
dc.relation.referencesLangmead, B., & Salzberg, S. L. (2012). Fast gapped-read alignment with Bowtie 2. Nature Methods, 9(4), 357–359. https://doi.org/10.1038/nmeth.1923
dc.relation.referencesLi, D., Liu, C. M., Luo, R., Sadakane, K., & Lam, T. W. (2015). MEGAHIT: An ultra-fast single-node solution for large and complex metagenomics assembly via succinct de Bruijn graph. Bioinformatics, 31(10), 1674–1676. https://doi.org/10.1093/bioinformatics/btv033
dc.relation.referencesLi, H., Handsaker, B., Wysoker, A., Fennell, T., Ruan, J., Homer, N., Marth, G., Abecasis, G., & Durbin, R. (2009). The Sequence Alignment/Map format and SAMtools. Bioinformatics, 25(16). https://doi.org/10.1093/bioinformatics/btp352
dc.relation.referencesLópez, Y., Muñoz-Leal, S., Martínez, C., Guzmán, C., Calderón, A., Martínez, J., Galeano, K., Muñoz, M., Ramírez, J. D., Faccini-Martínez, Á. A., & Mattar, S. (2023). Molecular evidence of Borrelia spp. in bats from Córdoba Department, northwest Colombia. Parasites and Vectors, 16(1). https://doi.org/10.1186/s13071-022-05614-y
dc.relation.referencesLopez-Baucells, A. (2018). When bats go viral: Negative framings in virological studies imperils bat conservation. https://doi.org/10.17863/CAM.21045
dc.relation.referencesLu, R., Zhao, X., Li, J., Niu, P., Yang, B., Wu, H., Wang, W., Song, H., Huang, B., Zhu, N., Bi, Y., Ma, X., Zhan, F., Wang, L., Hu, T., Zhou, H., Hu, Z., Zhou, W., Zhao, L., … Tan, W. (2020). Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. The Lancet, 395(10224), 565–574. https://doi.org/10.1016/S0140-6736(20)30251-8
dc.relation.referencesLuis, A. D., O’Shea, T. J., Hayman, D. T. S., Wood, J. L. N., Cunningham, A. A., Gilbert, A. T., Mills, J. N., & Webb, C. T. (2015). Network analysis of host-virus communities in bats and rodents reveals determinants of cross-species transmission. Ecology Letters, 18(11), 1153–1162. https://doi.org/10.1111/ele.12491
dc.relation.referencesMartínez, C., Echeverri, D., Calderón, A., Hurtado, E., Gastelbondo, B., López, Y., Martínez, J., López, Y., Botero, Y., Guzmán, C., Galeano, K., Bertel, V., Herrera, Y., Arrieta, G., Araujo, J. P., & Mattar, S. (2025). Bats from an area of the Colombian Caribbean reveal the circulation of Alphacoronavirus. Current Research in Parasitology & Vector-Borne Diseases, 100261. https://doi.org/10.1016/J.CRPVBD.2025.100261
dc.relation.referencesMartinez, S., Sullivan, A., Hagan, E., Goley, J., Epstein, J. H., Olival, K. J., Saylors, K., Euren, J., Bangura, J., Zikankuba, S., Moctar, M., Mouiche, M., Camara, A. O., Desmond, J., Islam, A., Hughes, T., Wacharplusadee, S., Duong, V., Thi, N., … Francisco, L. (2022). Living Safely With Bats: Lessons in Developing and Sharing a Global One Health Educational Resource. Glob Health Sci Pract, 10(6). https://doi.org/10.9745/GHSP-D-22-00106
dc.relation.referencesMeli, P., Carlos Imio, J., & Lisón, F. (2024). Tradeoffs in people’s perceptions about ecosystem services and disservices related to bats: Implications for managing agroecosystems and conserving bats. Ecosystem Services, 66. https://doi.org/10.1016/j.ecoser.2024.101609
dc.relation.referencesMinh, B. Q., Schmidt, H. A., Chernomor, O., Schrempf, D., Woodhams, M. D., Von Haeseler, A., Lanfear, R., & Teeling, E. (2020). IQ-TREE 2: New Models and Efficient Methods for Phylogenetic Inference in the Genomic Era. Molecular Biology and Evolution, 37(5), 1530–1534. https://doi.org/10.1093/molbev/msaa015
dc.relation.referencesMishra, N., Fagbo, S. F., Alagaili, A. N., Nitido, A., Williams, S. H., Ng, J., Lee, B., Durosinlorun, A., Garcia, J. A., Jain, K., Kapoor, V., Epstein, J. H., Briese, T., Memish, Z. A., Olival, K. J., & Ian Lipkin, W. (2019). A viral metagenomic survey identifies known and novel mammalian viruses in bats from Saudi Arabia. PLoS ONE, 14(4). https://doi.org/10.1371/journal.pone.0214227
dc.relation.referencesNanni, V., Mammola, S., Macías-Hernández, N., Castrogiovanni, A., Salgado, A. L., Lunghi, E., Ficetola, G. F., Modica, C., Alba, R., Spiriti, M. M., Holtze, S., de Mello, É. M., De Mori, B., Biasetti, P., Chamberlain, D., & Manenti, R. (2022). Global response of conservationists across mass media likely constrained bat persecution due to COVID-19. Biological Conservation, 272. https://doi.org/10.1016/j.biocon.2022.109591
dc.relation.referencesNIH. (2015). Public health service policy on humane care and use of laboratory animals. Office of Laboratory Animal Welfare. Okonechnikov, K., Golosova, O., Fursov, M., Varlamov, A., Vaskin, Y., Efremov, I., German Grehov, O. G., Kandrov, D., Rasputin, K., Syabro, M., & Tleukenov, T. (2012). Unipro UGENE: A unified bioinformatics toolkit. In Bioinformatics (Vol. 28, Issue 8, pp. 1166–1167). https://doi.org/10.1093/bioinformatics/bts091
dc.relation.referencesPeprah, D., Bangura, J., Vandi, M., Thomas, H., Dea, M., Schneider, A., & Chittenden, K. (2021). Social and political dimensions of disseminating research findings on emerging zoonotic viruses: Our experience in sierra leone. Global Health Science and Practice, 9(3). https://doi.org/10.9745/GHSP-D-20-00321
dc.relation.referencesPlowright, R. K., Peel, A. J., Streicker, D. G., Gilbert, A. T., McCallum, H., Wood, J., Baker, M. L., & Restif, O. (2016). Transmission or Within-Host Dynamics Driving Pulses of Zoonotic Viruses in Reservoir–Host Populations. In PLoS Neglected Tropical Diseases (Vol. 10, Issue 8). Public Library of Science. https://doi.org/10.1371/journal.pntd.0004796
dc.relation.referencesRacero-Casarrubia, J., Ballesteros, J., & Perez, J. (2015). racero, 2015. Biota Colombiana, 16(2), 128–148.
dc.relation.referencesRamírez-Chaves, H. E., Leuro Robles N G, Castaño Rivera A, Morales-Martínez D M, Suárez Castro A F, Rodríguez-Posada M E, Zurc D, Concha Osbahr D C, Trujillo A, Noguera Urbano E A, Pantoja Peña G E, González Maya J F, Pérez Torres J, Mantilla Meluk H, López Castañeda C, Velásquez Valencia A, & Zárrate Charry D. (2024). Mamíferos de Colombia. Sociedad Colombiana de Mastozoología. Dataset/Checklist. https://doi.org/https://doi.org/10.15472/kl1whs
dc.relation.referencesRamírez-Fráncel, L. A., García-Herrera, L. V., Guevara, G., Losada-Prado, S., Lim, B. K., Villa-Navarro, F. A., & Reinoso-Flórez, G. (2021). Human-bat interactions in central Colombia: Regional perceptions of a worldwide fragile life zone. Ethnobiology and Conservation, 10. https://doi.org/10.15451/EC2021-10-10.32-1-18
dc.relation.referencesRocha, R., Aziz, S. A., Brook, C. E., Carvalho, W. D., Cooper-Bohannon, R., Frick, W. F., Huang, J. C. C., Kingston, T., López-Baucells, A., Maas, B., Mathews, F., Medellin, R. A., Olival, K. J., Peel, A. J., Plowright, R. K., Razgour, O., Rebelo, H., Rodrigues, L., Rossiter, S. J., … Webala, P. W. (2021). Bat conservation and zoonotic disease risk: a research agenda to prevent misguided persecution in the aftermath of COVID-19. In Animal Conservation (Vol. 24, Issue 3, pp. 303–307). Blackwell Publishing Ltd. https://doi.org/10.1111/acv.12636
dc.relation.referencesRodríguez Rodríguez, V. (2023). TESIS LEPTOSPIRA Rodriguez 2023. [Universidad de Córdoba]. https://repositorio.unicordoba.edu.co/search?query=Leptospira%20Murci%C3%A9lagos
dc.relation.referencesRosero-Taramuel, J. L., Mejía-Fontecha, I. Y., Marín-Ramírez, A., Marín-Giraldo, V., & Ramírez-Chaves, H. E. (2023). Urban and peri-urban bats (Mammalia: Chiroptera) in Manizales, Colombia: exploring a conservation area in sub-Andean and Andean ecosystems. Mammalia, 87(6). https://doi.org/10.1515/mammalia-2022-0138
dc.relation.referencesRozewicki, J., Li, S., Amada, K. M., Standley, D. M., & Katoh, K. (2019). MAFFT-DASH: Integrated protein sequence and structural alignment. Nucleic Acids Research, 47(W1), W5–W10. https://doi.org/10.1093/nar/gkz342
dc.relation.referencesSeemann, T. (2014). Prokka: Rapid prokaryotic genome annotation. Bioinformatics, 30(14), 2068–2069. https://doi.org/10.1093/bioinformatics/btu153
dc.relation.referencesSoliman, K. M., & Emam, W. W. (n.d.). Bats and Ecosystem Management. www.intechopen.com
dc.relation.referencesSoliman, K. M., & Emam, W. W. (2022). Bats and Ecosystem Management. In Heimo Mikkola (Ed.), Bats - Disease-Prone but Beneficial. https://doi.org/10.5772/intechopen.101600
dc.relation.referencesTao, Y., Shi, M., Chommanard, C., Queen, K., Zhang, J., Markotter, W., Kuzmin, I. V., Holmes, E. C., & Tong, S. (2017). Surveillance of Bat Coronaviruses in Kenya Identifies Relatives of Human Coronaviruses NL63 and 229E and Their Recombination History. Journal of Virology, 91(5). https://doi.org/10.1128/jvi.01953-16
dc.relation.referencesVoigt, C. C., & Kingston, T. (2015). Bats in the anthropocene: Conservation of bats in a changing world. In Bats in the Anthropocene: Conservation of Bats in a Changing World. Springer International Publishing. https://doi.org/10.1007/978-3-319-25220-9
dc.relation.referencesWang, Z., Huang, G., Huang, M., Dai, Q., Hu, Y., Zhou, J., & Wei, F. (2022). Global patterns of phylogenetic diversity and transmission of bat coronavirus. Science China Life Sciences. https://doi.org/10.1007/s11427-022-2221-5
dc.relation.referencesWong, A. C. P., Li, X., Lau, S. K. P., & Woo, P. C. Y. (2019). Global epidemiology of bat coronaviruses. In Viruses (Vol. 11, Issue 2). MDPI AG. https://doi.org/10.3390/v11020174
dc.relation.referencesYao, D., Wang, Z., & Tang, Y. (2023). Ecological Change and Analysis of Public Opinion under Social Media Environment. Advances in Applied Sociology, 13(01). https://doi.org/10.4236/aasoci.2023.131003
dc.rightsCopyright Universidad de Córdoba, 2025
dc.rights.accessrightsinfo:eu-repo/semantics/embargoedAccess
dc.rights.coarhttp://purl.org/coar/access_right/c_f1cf
dc.rights.licenseAtribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.keywordsOne Healtheng
dc.subject.keywordsEcosystemeng
dc.subject.keywordsEnvironment and Public Healtheng
dc.subject.keywordsAlphacoronaviruseng
dc.subject.keywordsChiropteraeng
dc.subject.keywordsHost Adaptationeng
dc.subject.keywordsZoonoseseng
dc.subject.proposalOne Healthspa
dc.subject.proposalEcosistemaspa
dc.subject.proposalAmbiente y Salud Públicaspa
dc.subject.proposalAlphacoronavirusspa
dc.subject.proposalChiropteraspa
dc.subject.proposalAdapatación a hospederospa
dc.subject.proposalZoonosisspa
dc.titleVigilancia de coronavirus en murciélagos del departamento de Córdoba- Colombiaspa
dc.typeTrabajo de grado - Doctorado
dc.type.coarhttp://purl.org/coar/resource_type/c_db06
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.contentText
dc.type.driverinfo:eu-repo/semantics/doctoralThesis
dc.type.redcolhttp://purl.org/redcol/resource_type/TD
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dspace.entity.typePublication
Archivos
Bloque original
Mostrando 1 - 2 de 2
No hay miniatura disponible
Nombre:
MartínezBravoCatyMilena.pdf
Tamaño:
15.5 MB
Formato:
Adobe Portable Document Format
Descargar
No hay miniatura disponible
Nombre:
AutorizaciónPublicación.pdf
Tamaño:
273.26 KB
Formato:
Adobe Portable Document Format
Descargar
Bloque de licencias
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
license.txt
Tamaño:
15.18 KB
Formato:
Item-specific license agreed upon to submission
Descripción:
Descargar
Colecciones
G.F.A. Tesis