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Evaluación del eje de la hormona de crecimiento, factor de crecimiento similar a la insulina 1 y su principal proteína de unión 3, en una población con malaria por Plasmodium vivax y Geohelmintiasis.

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dc.audience
dc.contributor.advisorCantero Guevara, Miriam Elena
dc.contributor.advisorVelasco Pareja, María Camila
dc.contributor.authorRamos González, Luis Stevens
dc.contributor.authorBerrocal Almanza, Sonia Alejandra
dc.contributor.juryAlvis Ramos, Erasmo Manuel
dc.contributor.juryRuiz Pérez, Rander Antonio
dc.date.accessioned2025-07-18T16:40:32Z
dc.date.available2026-07-17
dc.date.available2025-07-18T16:40:32Z
dc.date.issued2025-07-16
dc.description.abstractLas enfermedades parasitarias, como la malaria y la geohelmintiasis, son un problema de salud pública, afectan el estado nutricional e inmunológico de las poblaciones afectadas. En Colombia, afectan principalmente a niños de áreas rurales y deprimidas. El Departamento de Córdoba es uno de los macro focos de malaria por Plasmodium vivax. En la actualidad, no está definida la relación del eje de la hormona de crecimiento (GH)/factor de crecimiento similar a la insulina-I (IGF-I), con las complicaciones clínicas de los pacientes con coinfección malaria por Plasmodium vivax - geohelmintiasis. Objetivo: Evaluar el efecto de la coinfección por Plasmodium vivax y geohelmintos, sobre la concentración plasmática del eje de la hormona de crecimiento (GH)/Factor de crecimiento similar a la insulina 1 (IGF-1) y la proteína de unión 3 al factor de crecimiento similar a la insulina 1 (IGFBP-3). Materiales y métodos: Se realizó un estudio, analítico y de corte transversal, donde participaron 60 individuos, distribuidos en 4 grupos, malaria (n=15); geohelmintiasis (n=15); coinfección malaria – geohemintiasis (n=15) e individuos aparentemente sanos (n=15), en la región de Tierralta (Córdoba- Colombia). El diagnóstico de la malaria se realizó por gota gruesa y la geohelmintiasis por Kato Katz. La concentración plasmática de albúmina se determinó mediante una técnica colorimétrica a través de la reacción con el colorante verde de bromocresol en un medio ligeramente ácido. La GH, el IGF-1 y la IGFBP-3 se determinaron por un ensayo inmunoabsorbente ligado a enzimas (ELISA), específico para cada molécula. Resultados. Se observó que los individuos de sexo masculino mostraron una mayor susceptibilidad a la coinfección malaria por P. vivax – geohelmintiasis, mientras que los participantes que se encontraban en edades >10 años presentaron mayor susceptibilidad a malaria y coinfección malaria por P. vivax – geohelmintiasis. Por otro lado, la especie de geohelmintos Trichuris trichiura, presentó mayor prevalencia de infección en la población de estudio. La concentración promedio de la albúmina (2,8 ± 0,53 g/dL), GH (8,3 ± 5,54 g/dL), IGF-1 (23,9 ± 10,9 g/dL) e IGFBP-3 (257,3 ± 136 g/dL) disminuyó significativamente en los pacientes con malaria con respecto a los controles (p ≤ 0,05). Conclusión: La coinfección por Plasmodium vivax– geohelmintiasis tienen un impacto negativo sobre el eje de la GH/GF-1 y su principal proteína de unión IGFBP-3, lo que en infecciones recurrentes puede afectar el estado nutricional y complicar a los pacientes con la coinfección malaria por P. vivax y geohelmintiasis.spa
dc.description.abstractParasitic diseases, such as malaria and geohelminthiasis, are a public health problem, affecting the nutritional and immunological status of affected populations. In Colombia, they mainly affect children in rural and depressed areas. The Department of Córdoba is one of the macro foci of malaria caused by Plasmodium vivax. At present, the relationship between the growth hormone (GH)/insulin-like growth factor-I (IGF-I) axis and the clinical complications of patients with Plasmodium vivax malaria co-infection - geohelminthiasis is not defined. Objective: To evaluate the effect of co-infection with Plasmodium vivax and geohelminths on the plasma concentration of the growth hormone (GH)/insulin-like growth factor 1 (IGF-1) axis and insulin-like growth factor 1 binding protein 3 (IGFBP-3). Materials and methods: An analytical, cross-sectional study was carried out with the participation of 60 individuals, distributed in 4 groups: malaria (n=15); geohelminthiasis (n=15); malaria-geoheminthiasis co-infection (n=15) and apparently healthy individuals (n=15), in the Tierralta region (Córdoba- Colombia). The diagnosis of malaria was made by thick drop and geohelminthiasis by Kato Katz. The plasma concentration of albumin was determined by a colorimetric technique through the reaction with the green dye bromocresol in a slightly acidic medium. GH, IGF-1, and IGFBP-3 were determined by an enzyme-linked immunosorbent assay (ELISA), specific to each molecule. Results: It was observed that male individuals showed a greater susceptibility to malaria coinfection with P. vivax – geohelminthiasis, while participants who were aged >10 years had greater susceptibility to malaria and coinfection malaria with P. vivax – geohelminthiasis. On the other hand, the species of geohelminths Trichuris trichiura presented a higher prevalence of infection in the study population. The average concentration of albumin (2.8 ± 0.53 g/dL), GH (8.3 ± 5.54 g/dL), IGF-1 (23.9 ± 10.9 g/dL), and IGFBP-3 (257.3 ± 136 g/dL) decreased significantly in malaria patients compared to controls (p ≤ 0.05). Conclusion: Co-infection by Plasmodium vivax-geohelminthiasis has a negative impact on the GH/GF-1 axis and its main binding protein IGFBP-3, which in recurrent infections can affect nutritional status and complicate patients with co-infection with P. vivax malaria and geohelminthiasis.eng
dc.description.degreelevelPregrado
dc.description.degreenameBacteriólogo(a)
dc.description.modalityArtículo
dc.description.tableofcontentsIntroducción
dc.description.tableofcontentsObjetivo general
dc.description.tableofcontentsObjetivos específicos
dc.description.tableofcontentsMateriales y Métodos
dc.description.tableofcontentsResultados
dc.description.tableofcontentsDiscusión
dc.description.tableofcontentsRecomendaciones
dc.description.tableofcontentsCoclusiones
dc.description.tableofcontentsAgradecimientos
dc.description.tableofcontentsReferencias bibliográficas
dc.format.mimetypeapplication/pdf
dc.identifier.instnameUniversidad de Córdoba
dc.identifier.reponameRepositorio Institucional Unicórdoba
dc.identifier.repourlhttps://repositorio.unicordoba.edu.co
dc.identifier.urihttps://repositorio.unicordoba.edu.co/handle/ucordoba/9399
dc.language.isospa
dc.publisherUniversidad de Córdoba
dc.publisher.facultyFacultad de Ciencias de la Salud
dc.publisher.programBacteriología
dc.relation.referencesColombia. Instituto Nacional de Salud. Protocolo de Vigilancia en Salud Pública de Malaria. versión 6. [Internet] 2024. https://doi.org/10.33610/FLCL8388
dc.relation.referencesWorld Health Organization. Report on the Situation of Malaria in the Americas. 2023
dc.relation.referencesHernández López LV. Efecto de la diversidad y abundancia de vectores sobre la transmisión de la Malaria en Córdoba, Colombia. 2021.
dc.relation.referencesGeohelmintiasis. (s. f.-b) [Internet]. Paho.org. 2022. Disponible en: https://www.paho.org/es/temas/geohelmintiasis.
dc.relation.referencesINd S. Informe De Evento Malaria, Colombia, Semana Epidemiológica 24, 2019. 2019.
dc.relation.referencesINd S. Informe de Evento: MALARIA. Período epidemiológico XIII. Colombia, 2019. 2020.
dc.relation.referencesMora-Criollo P, Basu R, Qian Y, Costales JA, Guevara-Aguirre J, Grijalva MJ, et al. Growth hormone modulates Trypanosoma cruzi infection in vitro. Growth Hormone & IGF Research 2022;64:101460. https://doi.org/10.1016/j.ghir.2022.101460
dc.relation.referencesYbern MLG. Factor de crecimiento similar a la insulina y sus proteínas de transporte. Endocrinología y Nutrición 2006;53(7):467-475. https://doi.org/10.1016/S1575-0922(06)71133-0
dc.relation.referencesVargas M, Hernández E. The social determinants of child malnutrition in Colombia from a family medicine perspective. Medwave 2020;20(2):e7839. https://doi.org/10.5867/medwave.2020.02.7839
dc.relation.referencesAfolabi MO, Ale BM, Dabira ED, Agbla SC, Bustinduy AL, Ndiaye JLA, et al. Malaria and helminth co-infections in children living in endemic countries: A systematic review with meta-analysis. PLoS neglected tropical diseases 2021;15(2):e0009138. https://doi.org/10.1371/journal.pntd.0009138
dc.relation.referencesLS S. The public health significance of Trichuris trichiura. Parasitology 2000;121:S73-S95. https://doi.org/10.1017/S0031182000006867
dc.relation.referencesRestrepo Von Schiller IC, Mazo Berrío LP, Salazar Giraldo ML, Montoya Palacio MN, Botero Garcés JH. Evaluación de tres técnicas coproparasitoscópicas para el diagnóstico de geohelmintos intestinales. Iatreia 2013;26(1):15-24. https://doi.org/10.17533/udea.iatreia.14342
dc.relation.referencesNjua-Yafi C, Achidi EA, Anchang-Kimbi JK, Apinjoh TO, Mugri RN, Chi HF, et al. Malaria, helminths, co-infection and anaemia in a cohort of children from Mutengene, south western Cameroon. Malaria journal 2016;15:1-11. https://doi.org/10.1186/s12936-016-1111-2
dc.relation.referencesTeklemariam A, Alemseged M, Adugna S. Malaria-intestinal helminthes co-infection among patients in Wolkite health center and Attat hospital, Gurage zone, southern Ethiopia. Journal of Parasitology and Vector Biology 2018;10(2):26–32.
dc.relation.referencesFernández-Niño JA, Idrovo AJ, Cucunubá ZM, Reyes-Harker P, Guerra ÁP, Moncada LI, et al. Paradoxical associations between soil-transmitted helminths and Plasmodium falciparum infection. Trans R Soc Trop Med Hyg 2012;106(11):701-708. https://doi.org/10.1016/j.trstmh.2012.07.012
dc.relation.referencesEaston AV, Raciny-Aleman M, Liu V, Ruan E, Yasnot MF, Rodriguez A, et al. The immune response and microbiota profiles during co-infection with P. vivax and soil-transmitted helminths. bioRxiv 2020:2020.01. 30.925032. https://doi.org/10.1101/2020.01.30.925032
dc.relation.referencesNoland GS, Graves PM, Sallau A, Eigege A, Emukah E, Patterson AE, et al. Malaria prevalence, anemia and baseline intervention coverage prior to mass net distributions in Abia and Plateau States, Nigeria. BMC infectious diseases 2014;14:1-13. https://doi.org/10.1186/1471-2334-14-168
dc.relation.referencesSousa-Figueiredo JC, Gamboa D, Pedro JM, Fançony C, Langa AJ, Soares Magalhães RJ, et al. Epidemiology of malaria, schistosomiasis, geohelminths, anemia and malnutrition in the context of a demographic surveillance system in northern Angola. PloS one 2012;7(4):e33189. https://doi.org/10.1371/journal.pone.0033189
dc.relation.referencesGenton B. Distribution and risk factors for Plasmodium and helminth co-infections: a cross-sectional survey among children in Bagamoyo district, coastal region of Tanzania. 2015.
dc.relation.referencesKojom Foko LP, Nolla NP, Nyabeyeu Nyabeyeu H, Tonga C, Lehman LG. Prevalence, Patterns, and Determinants of Malaria and Malnutrition in Douala, Cameroon: A Cross‐Sectional Community‐Based Study. BioMed research international 2021;2021(1):5553344. https://doi.org/10.1155/2021/5553344
dc.relation.referencesVelasco Pareja MC. Moléculas asociadas a anemia y trombocitopenia en pacientes con malaria por Plasmodium vivax. 2021.
dc.relation.referencesRodríguez-Morales AJ, Sánchez E, Vargas M, Piccolo C, Colina R, Arria M, et al. Is anemia in Plasmodium vivax malaria more frequent and severe than in Plasmodium falciparum? Am J Med 2006;119(11):e9-e10. https://doi.org/10.1016/j.amjmed.2005.08.014
dc.relation.referencesBretscher C, Boesiger F, Kaegi-Braun N, Hersberger L, Lobo DN, Evans DC, et al. Admission serum albumin concentrations and response to nutritional therapy in hospitalised patients at malnutrition risk: secondary analysis of a randomised clinical trial. EClinicalMedicine 2022;45. https://doi.org/10.1016/j.eclinm.2022.101301
dc.relation.referencesClark IA, Alleva LM, Mills AC, Cowden WB. Pathogenesis of malaria and clinically similar conditions. Clin Microbiol Rev 2004;17(3):509-539. https://doi.org/10.1128/CMR.17.3.509-539.2004
dc.relation.referencesStephenson LS, Latham MC, Ottesen EA. Malnutrition and parasitic helminth infections. Parasitology 2000;121(S1):S23-S38. https://doi.org/10.1017/S0031182000006491
dc.relation.referencesBrooker S, Akhwale W, Pullan R, Estambale B, Clarke SE, Snow RW, et al. Epidemiology of Plasmodium-helminth co-infection in Africa: populations at risk, potential impact on anemia and prospects for combining control. Am J Trop Med Hyg 2007;77(6 Suppl):88. https://doi.org/10.4269/ajtmh.2007.77.88
dc.relation.referencesGomes CM, Giannella-Neto D, Gama ME, Pereira JCR, Campos MB, Corbett CE. Correlation between the components of the insulin-like growth factor I system, nutritional status and visceral leishmaniasis. Trans R Soc Trop Med Hyg 2007;101(7):660-667. https://doi.org/10.1016/j.trstmh.2007.02.017
dc.relation.referencesFan J, Char D, Kolasa AJ, Pan W, Maitra SR, Patlak CS, et al. Alterations in hepatic production and peripheral clearance of IGF-I after endotoxin. American Journal of Physiology-28. Fan J, Char D, Kolasa AJ, Pan W, Maitra SR, Patlak CS, et al. Alterations in hepatic production and peripheral clearance of IGF-I after endotoxin. American Journal of Physiology-Endocrinology and Metabolism 1995;269(1):E33-E42. https://doi.org/10.1152/ajpendo.1995.269.1.E33 Endocrinology and Metabolism 1995;269(1):E33-E42. https://doi.org/10.1152/ajpendo.1995.269.1.E33
dc.relation.referencesLelbach A, Scharf J, Ramadori G. Regulation of insulin-like growth factor-I and of insulin-like growth factor binding protein-1,-3 and-4 in cocultures of rat hepatocytes and Kupffer cells by interleukin-6. J Hepatol 2001;35(5):558-567. https://doi.org/10.1016/S0168-8278(01)00170-2
dc.relation.referencesMaleta K, Fan Y, Luoma J, Ashorn U, Bendabenda J, Dewey KG, et al. Infections and systemic inflammation are associated with lower plasma concentration of insulin-like growth factor I among Malawian children. Am J Clin Nutr 2021;113(2):380-390. https://doi.org/10.1093/ajcn/nqaa327
dc.relation.referencesMizushima Y, Kato H, Ohmae H, Tanaka T, Bobogare A, Ishii A. Prevalence of malaria and its relationship to anemia, blood glucose levels, and serum somatomedin c (IGF-1) levels in the Solomon Islands. Acta Trop 1994;58(3-4):207-220. https://doi.org/10.1016/0001-706X(94)90015-9
dc.relation.referencesKurniawan F, Tahapary DL, de Ruiter K, Yunir E, Biermasz NR, Smit JW, et al. Effect of anthelmintic treatment on serum free IGF-1 and IGFBP-3: a cluster-randomized-controlled trial in Indonesia. Scientific reports 2020;10(1):19023. https://doi.org/10.1038/s41598-020-75781-4
dc.relation.referencesWatts EL, Perez‐Cornago A, Appleby PN, Albanes D, Ardanaz E, Black A, et al. The associations of anthropometric, behavioural and sociodemographic factors with circulating concentrations of IGF‐I, IGF‐II, IGFBP‐1, IGFBP‐2 and IGFBP‐3 in a pooled analysis of 16,024 men from 22 studies. International journal of cancer 2019;145(12):3244-3256. https://doi.org/10.1002/ijc.32276
dc.rights.accessrightsinfo:eu-repo/semantics/embargoedAccess
dc.rights.coarhttp://purl.org/coar/access_right/c_f1cf
dc.rights.licenseAtribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.keywordsGH
dc.subject.keywordsIGF-1
dc.subject.keywordsIGFBP-3
dc.subject.keywordsMalaria
dc.subject.keywordsGeohelminthiasis
dc.subject.proposalGH
dc.subject.proposalIGF-1
dc.subject.proposalIGFBP-3
dc.subject.proposalMalaria
dc.subject.proposalGeohelmintiasis
dc.titleEvaluación del eje de la hormona de crecimiento, factor de crecimiento similar a la insulina 1 y su principal proteína de unión 3, en una población con malaria por Plasmodium vivax y Geohelmintiasis.spa
dc.typeTrabajo de grado - Pregrado
dc.type.coarhttp://purl.org/coar/resource_type/c_7a1f
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.contentText
dc.type.driverinfo:eu-repo/semantics/bachelorThesis
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
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