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Actividad antifúngica de extractos obtenidos de Zanthoxylum caribaeum (Rutaceae) contra aislados clínicos de Candida spp. (Saccharomycetales: Saccharomycetaceae)

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dc.contributor.advisorContreras Martínez Orfa Inésspa
dc.contributor.advisorAngulo Ortiz Alberto Antoniospa
dc.contributor.authorPérez Noriega, Gabriela
dc.date.accessioned2023-08-04T17:35:31Z
dc.date.available2025-08-01
dc.date.available2023-08-04T17:35:31Z
dc.date.issued2023-08-04
dc.description.abstractLa incidencia de Candida spp., en las infecciones intrahospitalarias, su resistencia a múltiples fármacos y su elevada tasa de mortalidad, principalmente en personas inmunocomprometidas, han convertido su tratamiento en una tarea desafiante para el personal de la salud. Actualmente se ha informado del efecto antifúngico de compuestos naturales como posibles alternativas a utilizar. El objetivo de este estudio fue evaluar la actividad antifúngica de los extractos EtOH de hojas y corteza obtenidos de Zanthoxylum caribaeum Lam (Rutaceae) contra aislados clínicos de Candida spp. Para los ensayos de actividad antifúngica se empleó el método de microdilución en caldo y se encontró efecto inhibidor del crecimiento de Candida spp., con Concentraciones Mínimas Inhibitorias (CMI) de 125 a 3500 μg/mL. Los extractos mostraron ser erradicadores de biopelículas maduras, en algunos casos con un mayor efecto que la Anfotericina B (AFB). Mediciones en el pH extracelular y ensayos de tinción con azul de Evans revelaron daño en la integridad de la membrana fúngica con liberación de constituyentes intracelular comparado con células no tratadas. Estos resultados sirven como base para futuros estudios encaminados en la búsqueda de compuestos activos de origen vegetal contra Candida spp.spa
dc.description.degreelevelPregradospa
dc.description.degreenameBiólogo(a)spa
dc.description.modalityArtículospa
dc.description.tableofcontentsResumen ______________________________________1spa
dc.description.tableofcontentsIntroducción ___________________________________1spa
dc.description.tableofcontentsMateriales y Métodos ___________________________ 2spa
dc.description.tableofcontentsResultados ____________________________________ 5spa
dc.description.tableofcontentsDiscusión _____________________________________ 12spa
dc.description.tableofcontentsConclusión ____________________________________ 13spa
dc.description.tableofcontentsRecomendaciones ___________________________ 13spa
dc.description.tableofcontentsAgradecimientos _____________________________ 13spa
dc.description.tableofcontentsReferencias __________________________________ 13spa
dc.format.mimetypeapplication/pdfspa
dc.identifier.urihttps://repositorio.unicordoba.edu.co/handle/ucordoba/7578
dc.language.isospaspa
dc.publisher.facultyFacultad de Ciencias Básicasspa
dc.publisher.placeMontería, Córdoba, Colombiaspa
dc.publisher.programBiologíaspa
dc.rightsCopyright Universidad de Córdoba, 2023spa
dc.rights.accessrightsinfo:eu-repo/semantics/embargoedAccessspa
dc.rights.creativecommonsAtribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)spa
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/spa
dc.subject.keywordsAntifungaleng
dc.subject.keywordsCandidaeng
dc.subject.keywordsExtracteng
dc.subject.keywordsSecondary metaboliteseng
dc.subject.proposalAntifúngicospa
dc.subject.proposalCandidaspa
dc.subject.proposalExtractospa
dc.subject.proposalMetabolitos secundariosspa
dc.titleActividad antifúngica de extractos obtenidos de Zanthoxylum caribaeum (Rutaceae) contra aislados clínicos de Candida spp. (Saccharomycetales: Saccharomycetaceae)spa
dc.typeTrabajo de grado - Pregradospa
dc.type.coarhttp://purl.org/coar/resource_type/c_7a1fspa
dc.type.contentTextspa
dc.type.driverinfo:eu-repo/semantics/articlespa
dc.type.redcolhttps://purl.org/redcol/resource_type/ART
dc.type.versioninfo:eu-repo/semantics/submittedVersionspa
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