Every territorial entity must be attentive to the public health of the population, at a global level given the Covid-19 pandemic, social coexistence and mental health was one of the affected dimensions. Therefore, this business practice aimed to analyze the actions of the social coexistence and mental health component developed by the Ministry of Health of the municipality of Cereté, Córdoba, Colombia during the Covid-19 pandemic, years 2020 to 2021. As a methodology for the development from practice, observation and analysis were used; A diagnosis was made using the DOFA matrix and a checklist was designed to verify the activities that comply with three actions proposed by the Ministry of Health. As a result, it was found that the activities carried out were moderately fulfilled, given the accessibility restrictions due to the Covid-19 pandemic, the expected staff did not attend due to the fear caused by the fact of being infected if they went out into the street; therefore, a large part of the activities were carried out by telephone. The activities carried out encouraged the participants to express the various situations they presented such as suicide attempts, domestic violence, consumption of psychoactive substances, and sexual abuse. The interventions carried out allowed a great advance in the recognition of the problems by the actors, and the acceptance to receive the intervention as a means of facing and seeking a solution to their problems. It is expected that in the post-pandemic period these interventions will continue to be carried out through which full compliance with the actions and activities of the Ministry of Health will be achieved, in order to improve the social coexistence and mental health component