Publicación:
Detección de DENV y ZIKV en pacientes con síndrome febril agudo en el departamento de Córdoba

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dc.contributor.advisorRicardo Caldera, Dina Marcela
dc.contributor.authorAvilés Vergara, Paula Andrea
dc.date.accessioned2022-01-25T23:27:30Z
dc.date.available2022-01-25T23:27:30Z
dc.date.issued2022-01-24
dc.description.abstractObjective To determine simultaneous circulation of DENV serotypes and ZIKV in Córdoba, Colombia, during 2015 and 2016. Material and methods A total of 294 samples from patients with clinical diagnosis of febrile syndrome compatible with dengue were collected between June 2015 and December 2016. All samples were tested for DENV and ZIKV by RT-PCR using C6/36 cells culture supernatant. Results Thirty-three percent of the samples were positive (97/294); from these, 61.8% were positive for DENV and 31% were positive for Zika. The predominant serotype was DENV-2 (70.1%), followed by DENV-3 (8.9%), DENV-4 (6%), and DENV-1 (3%). DENV/ZIKV coinfection was identified in 7.2% of the cases associated with DENV-2 and DENV-4 serotypes. The confirmed cases of dengue, Zika, and DENV/ZIKV coinfections were clinically mild and self-limited. Conclusions We reported the co-circulation of all four DENV serotypes, with a higher frequency of DENV-2. ZIKV introduction in Córdoba department-Colombia in August 2015 favored the appearance of DENV/ZIKV coinfections.eng
dc.description.degreelevelMaestríaspa
dc.description.degreenameMagíster en Microbiología Tropicalspa
dc.description.modalityTrabajos de Investigación y/o Extensiónspa
dc.description.resumenObjetivo: Detectar la co-circulación de los serotipos del DENV y confirmar la circulación simultánea de ZIKV en el departamento de Córdoba. Materiales y métodos: Se recolectaron 294 muestras de pacientes con diagnóstico clínico de síndrome febril agudo y con sospecha clinica de dengue entre junio de 2015 y diciembre de 2016. Todas las muestras fueron analizadas para DENV y ZIKV mediante RT-PCR utilizando sobrenadante de cultivo de células C6/36. Resultados: El 33% de las muestras fueron positivas (97/294); de ellas, el 61,8% fueron positivas para el DENV y el 31% para el Zika. El serotipo predominante fue el DENV-2 (70,1%), seguido del DENV-3 (8,9%), el DENV-4 (6%) y el DENV-1 (3%). La coinfección DENV/ZIKV se identificó en el 7,2% de los casos, asociados a los serotipos DENV-2 y DENV-4. Los casos confirmados de dengue, Zika y coinfecciones DENV/ZIKV fueron clínicamente leves y autolimitados. Conclusiones: Reportamos la co-circulación de los cuatro serotipos de DENV, con una mayor frecuencia de DENV-2. La introducción del ZIKV en el departamento de Córdoba-Colombia en agosto de 2015, favoreció la aparición de coinfecciones por DENV/ZIKV.spa
dc.description.tableofcontents1. INTRODUCCIÓN ..................................................................................................................................... 10spa
dc.description.tableofcontents2.JUSTIFICACIÓN................................................................................................................................13spa
dc.description.tableofcontents3.MARCOTEÓRICO.............................................................................................................................14spa
dc.description.tableofcontents3.1Epidemiología.............................................................................................................................. 14spa
dc.description.tableofcontents3.1.1 Serotipos y genotipos del DENV.............................................................................................. 15spa
dc.description.tableofcontents3.2 Biología del virus ....................................................................................................................... 16spa
dc.description.tableofcontents3.2.1 Estructura y genoma del DENV ............................................................................................... 16spa
dc.description.tableofcontents3.2.2 Transmisión y ciclo de vida ..................................................................................................... 18spa
dc.description.tableofcontents3.3 Interacciones primarias del DENV con componentes de la respuesta inmune innata. ............. 19spa
dc.description.tableofcontents3.3.1 Respuesta inmunitaria innata contra el DENV........................................................................ 19spa
dc.description.tableofcontents3.3.2 Respuesta inmunitaria adaptativa contra el DENV ................................................................. 20spa
dc.description.tableofcontents3.4 Inmunopatogénesis de la enfermedad por el virus del dengue ................................................ 21spa
dc.description.tableofcontents3.4.1 Mejora de la enfermedad dependiente de anticuerpos (ADE) ............................................... 21spa
dc.description.tableofcontents3.4.2 El fenómeno del pecado antigénico original........................................................................... 22spa
dc.description.tableofcontents3.5 Diagnóstico................................................................................................................................. 23spa
dc.description.tableofcontents3.6 Vigilancia, prevención y control ............................................................................................... 24spa
dc.description.tableofcontents4. OBJETIVOS................................................................................................................................... 25spa
dc.description.tableofcontents4.1 Objetivo general ........................................................................................................................ 25spa
dc.description.tableofcontents4.2 Objetivos específicos.................................................................................................................. 25spa
dc.description.tableofcontents5. METODOLOGÍA ............................................................................................................................ 26spa
dc.description.tableofcontents5.1 Tipo, lugar y diseño del estudio.................................................................................................. 26spa
dc.description.tableofcontents5.2 Muestras..................................................................................................................................... 27spa
dc.description.tableofcontents5.3 Aislamiento viral en línea celular C6/36..................................................................................... 27spa
dc.description.tableofcontents5.4 Detección Molecular por RT-PCR para DENV ........................................................................... 28spa
dc.description.tableofcontents5.5 RT-PCR ZIKV................................................................................................................................ 28spa
dc.description.tableofcontents5.6 Análisis estadístico...................................................................................................................... 29spa
dc.description.tableofcontents5.7 Consideraciones éticas .............................................................................................................. 29spa
dc.description.tableofcontents6. RESULTADOS................................................................................................................................ 30spa
dc.description.tableofcontents7. DISCUSIÓN.................................................................................................................................... 34spa
dc.description.tableofcontents8. CONCLUSIONES ........................................................................................................................... 37spa
dc.description.tableofcontents9. PERSPECTIVAS Y RECOMENDACIONES ........................................................................................ 38spa
dc.description.tableofcontents10. REFERENCIAS BIBLIOGRÁFICAS................................................................................................... 39spa
dc.description.tableofcontents11. ANEXOS....................................................................................................................................... 46spa
dc.format.mimetypeapplication/pdfspa
dc.identifier.urihttps://repositorio.unicordoba.edu.co/handle/ucordoba/4773
dc.language.isospaspa
dc.publisher.facultyFacultad de Medicina Veterinaria y Zootecniaspa
dc.publisher.placeBerástegui, Córdoba, Colombiaspa
dc.publisher.programMaestría en Microbiología Tropicalspa
dc.rightsCopyright Universidad de Córdoba, 2022spa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.creativecommonsAtribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)spa
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/spa
dc.subject.keywordsDengue viruseng
dc.subject.keywordsZika Viruseng
dc.subject.keywordsCoinfectioneng
dc.subject.keywordsColombiaeng
dc.subject.proposalVirus del denguespa
dc.subject.proposalVirus del Zikaspa
dc.subject.proposalCoinfeccionesspa
dc.subject.proposalColombiaspa
dc.titleDetección de DENV y ZIKV en pacientes con síndrome febril agudo en el departamento de Córdobaspa
dc.typeTrabajo de grado - Maestríaspa
dc.type.coarhttp://purl.org/coar/resource_type/c_bdccspa
dc.type.contentTextspa
dc.type.driverinfo:eu-repo/semantics/masterThesisspa
dc.type.redcolhttps://purl.org/redcol/resource_type/TMspa
dc.type.versioninfo:eu-repo/semantics/submittedVersionspa
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