Publicación:
Caracterización genética de influenzavirus y coronavirus en murciélagos de los departamentos de Córdoba y Bolívar- Colombia

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dc.audience
dc.contributor.advisorMartinez Bravo, Caty Milena
dc.contributor.advisorGastelbondo Pastrana, Bertha Irina
dc.contributor.authorEcheverri De la Hoz, Daniel Mauricio
dc.contributor.educationalvalidatorMattar Velilla, Salim
dc.contributor.juryRodriguez Villamizar, Fernando
dc.contributor.jurySoler-Tovar, Diego
dc.date.accessioned2024-07-10T15:03:46Z
dc.date.available2025-07-10
dc.date.available2024-07-10T15:03:46Z
dc.date.issued2024-07-10
dc.description.abstractLos murciélagos son un grupo de mamíferos caracterizados por albergar patógenos de importancia en salud pública y animal. A pesar de ser caracterizados como un grupo taxonómica de vigilancia epidemiológica, el surgimiento del nuevo influenza virus de murciélagos y la reciente pandemia del COVID-19 causada por el SARS-CoV-2, aumentó el interés de los investigadores en comprender el papel de estos mamíferos en el mantenimiento y circulación de dichos virus. El objetivo de este estudio fue caracterizar la diversidad genética de coronavirus e influenza virus en murciélagos de los departamentos de Córdoba y Bolívar, Colombia. Se procesaron 106 animales para la detección molecular de coronavirus e influenza. Quince muestras fueron secuenciadas por RNA-Seq (NGS). Se obtuvo el genoma completo de un coronavirus y un influenza virus. Los análisis filogenéticos y reloj molecular indican que se trata de un nuevo virus del género Alphacoronavirus altamente divergente que proviene de un nodo ancestral. Mientras que, el influenza virus está asociado a los influenza A virus de murciélagos descritos anteriormente. En el análisis de la arquitectura antigénica, la proteína Spike del AlphaCov muestra similitud con TGEV y HCoV-229E con capacidad de unirse al CD13 de humanos y porcinos. La neuraminidasa del influenza A virus presenta cambios antigénicos en el sitio putativo de unión que le permite unirse al HLA-DR de murciélagos, lo que sugiere que recupera su actividad catalítica. Este es el primer estudio de caracterización filogenética, evolutiva y antigénica de coronavirus e influenza virus en murciélagos de Colombia.spa
dc.description.abstractBats are a group of mammals characterized by harboring pathogens of importance in public and animal health. Despite being characterized as a taxonomic epidemiological surveillance group, the emergence of the new bat influenza virus and the recent COVID-19 pandemic caused by SARS-CoV-2, increased the interest of researchers in understanding the role of these mammals in the maintenance and circulation of these viruses. The objective of this study was to characterize the genetic diversity of coronaviruses and influenza viruses in bats from the departments of Córdoba and Bolívar, Colombia. We process 106 animals for the molecular detection of coronavirus and influenza. Fifteen samples were sequenced by RNA-Seq (NGS). The complete genome of a coronavirus and an influenza virus was obtained. Phylogenetic analyses and molecular clock indicate that it is a new virus of the genus Alphacoronavirus, highly divergent, that comes from an ancestral node. Influenza viruses are associated with the influenza A bat viruses described above. In the analysis of the antigenic architecture, the AlphaCov Spike protein shows similarity to TGEV and HCoV-229E with the ability to bind to CD13 from humans and pigs. The neuraminidase of influenza A virus exhibits antigenic changes at the putative binding site that allows it to bind to bat HLA-DR, suggesting that it regains its catalytic activity. This is the first study of phylogenetic, evolutionary and antigenic characterization of coronaviruses and influenza viruses in bats in Colombia.eng
dc.description.degreelevelMaestría
dc.description.degreenameMagíster en Microbiología Tropical
dc.description.modalityTrabajos de Investigación y/o Extensión
dc.description.tableofcontents1. Introducción...13spa
dc.description.tableofcontents2. Objetivo general...17spa
dc.description.tableofcontents2.1 Objetivos específicos...17spa
dc.description.tableofcontents3. Marco conceptual...18spa
dc.description.tableofcontents3.1 Caracteríticas generales de los murciélagos...18spa
dc.description.tableofcontents3.2 Los murciélagos como reservorios de patógenos virales emergentes y reemergentes...18spa
dc.description.tableofcontents3.3 Virus en murciélagos del nuevo mundo...21spa
dc.description.tableofcontents3.3.1 Coronavirus en murciélagos...23spa
dc.description.tableofcontents3.3.2 Influenzavirus en murciélagos...26spa
dc.description.tableofcontents3.4 Caracterización genética de los virus en murciélagos...29spa
dc.description.tableofcontents3.5 El sistema inmune de los murciélagos en la conservación y trasmisión de los virus...30spa
dc.description.tableofcontents3.6 Factores asociados al contacto murciélago-humano y la diseminación de virus patógenos...31spa
dc.description.tableofcontents4. Materiales y métodos...33spa
dc.description.tableofcontents4.1 Ubicación y tipo de estudio...33spa
dc.description.tableofcontents4.2 Tipo de muestra...33spa
dc.description.tableofcontents4.3 Componentes éticos...33spa
dc.description.tableofcontents4.4 Metodología para el cumplimiento del objetivo específico 1...34spa
dc.description.tableofcontents4.4.1 Extracción de material genético...34spa
dc.description.tableofcontents4.4.2 Identificación molecular...35spa
dc.description.tableofcontents4.5 Metodología para el cumplimiento del objetivo específico 2...36spa
dc.description.tableofcontents4.5.1 Secuenciación de Nueva Generación (NGS)...36spa
dc.description.tableofcontents4.5.2 Análisis bioinformático...37spa
dc.description.tableofcontents4.5.2.1 Procesamiento de secuencias...37spa
dc.description.tableofcontents4.5.2.2 Recuperación de genomas y análisis filogenético...38spa
dc.description.tableofcontents4.5.3 Reconstrucción filogenética y estimación del ancestro común más cercano (TMCRA)...38spa
dc.description.tableofcontents4.6 Metodología para el cumplimiento del objetivo específico número 3...39spa
dc.description.tableofcontents4.6.1 Modelamiento de la estructura antigénica...39spa
dc.description.tableofcontents4.6.1.1 Obtención de modelos 3D...39spa
dc.description.tableofcontents4.6.1.2 Predicción de epítopos predichos...39spa
dc.description.tableofcontents4.6.2 Docking molecular (proteína-proteína)...40spa
dc.description.tableofcontents4.7 Metodología para el cumplimiento del objetivo específico número 4....40spa
dc.description.tableofcontents4.7.1 Estrategias de difusión...40spa
dc.description.tableofcontents4.7.1.1 Población...40spa
dc.description.tableofcontents4.7.1.2 Diseño y ejecución de las estrategias de difusión...41spa
dc.description.tableofcontents5. Resultados....42spa
dc.description.tableofcontents5.1 Resultados relacionados con el cumplimiento del objetivo específico número 1...42spa
dc.description.tableofcontents5.1.1 Extracción de material genético y detección molecular...42spa
dc.description.tableofcontents5.2 Resultados relacionados con el cumplimiento del objetivo específico número 2...44spa
dc.description.tableofcontents5.2.1 Secuenciación y análisis bioinformático ....44spa
dc.description.tableofcontents5.2.1.1 Optimización de muestras para obtención de genomas de CoV...45spa
dc.description.tableofcontents5.2.1.2 Optimización de muestras para secuenciación de genoma de IV...45spa
dc.description.tableofcontents5.2.2 Análisis filogenético....46spa
dc.description.tableofcontents5.2.2.1 Coronavirus....46spa
dc.description.tableofcontents5.2.2.2 Influenza A virus...50spa
dc.description.tableofcontents5.2.3 Determinación del ancestro común más cercano (TMCRA)...52spa
dc.description.tableofcontents5.2.3.1 Coronavirus...52spa
dc.description.tableofcontents5.2.3.2 Influenza A virus ...53spa
dc.description.tableofcontents5.3 Resultados relacionados con el cumplimiento del objetivo específico 3...54spa
dc.description.tableofcontents5.3.1 Modelamiento de la proteína de la espícula (S) de coronavirus...54spa
dc.description.tableofcontents5.3.1.1 Docking molecular...57spa
dc.description.tableofcontents5.3.2 Modelamiento de la neuraminidasa (N) de Influenza A virus...59spa
dc.description.tableofcontents5.3.2.1 Docking molecular...63spa
dc.description.tableofcontents5.4 Resultados relacionados con el cumplimiento del objetivo específico 4...63spa
dc.description.tableofcontents5.4.1 Comunidades rurales...63spa
dc.description.tableofcontents5.4.2 Población estudiantil...65spa
dc.description.tableofcontents6. Discusión...66spa
dc.description.tableofcontents7. Conclusiones...74spa
dc.description.tableofcontents8. Recomendaciones...75spa
dc.description.tableofcontents9. Glosario...75spa
dc.description.tableofcontents10. Referencias...76spa
dc.description.tableofcontents11. Anexos...93spa
dc.format.mimetypeapplication/pdf
dc.identifier.instnameUniversidad de Córdoba
dc.identifier.reponameRepositorio Universidad de Córdoba
dc.identifier.repourlhttps://repositorio.unicordoba.edu.co
dc.identifier.urihttps://repositorio.unicordoba.edu.co/handle/ucordoba/8368
dc.language.isospa
dc.publisherUniversidad de Córdoba
dc.publisher.facultyFacultad de Medicina Veterinaria y Zootecnia
dc.publisher.placeMontería, Córdoba, Colombia
dc.publisher.programMaestría en Microbiología Tropical
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dc.rightsCopyright Universidad de Córdoba, 2024
dc.rights.accessrightsinfo:eu-repo/semantics/embargoedAccess
dc.rights.coarhttp://purl.org/coar/access_right/c_f1cf
dc.rights.licenseAtribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.keywordsViruses
dc.subject.keywordsNeotropical bats
dc.subject.keywordsColombian Caribbean
dc.subject.keywordsZoonosis
dc.subject.proposalVirus
dc.subject.proposalMurciélagos neotropicales
dc.subject.proposalCaribe Colombiano
dc.subject.proposalZoonosis
dc.titleCaracterización genética de influenzavirus y coronavirus en murciélagos de los departamentos de Córdoba y Bolívar- Colombiaspa
dc.typeTrabajo de grado - Maestría
dc.type.coarhttp://purl.org/coar/resource_type/c_bdcc
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.contentText
dc.type.driverinfo:eu-repo/semantics/masterThesis
dc.type.redcolhttp://purl.org/redcol/resource_type/TM
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dspace.entity.typePublication
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