Publicación:
Farmacocinética y efectos adversos de la doxiciclina en el tratamiento de la Ehrlichiosis: fundamentos teóricos para ensayos clínicos en caninos

dc.contributor.authorMonsalve B, Santiagospa
dc.contributor.authorGallego L, Vanessaspa
dc.contributor.authorMolina, Victor Manuelspa
dc.contributor.authorRodas G, Juanspa
dc.date.accessioned2017-05-25 00:00:00
dc.date.accessioned2022-07-01T21:00:36Z
dc.date.available2017-05-25 00:00:00
dc.date.available2022-07-01T21:00:36Z
dc.date.issued2017-05-25
dc.format.mimetypeapplication/pdfspa
dc.identifier.doi10.21897/rmvz.1076
dc.identifier.eissn1909-0544
dc.identifier.issn0122-0268
dc.identifier.urihttps://repositorio.unicordoba.edu.co/handle/ucordoba/5891
dc.identifier.urlhttps://doi.org/10.21897/rmvz.1076
dc.language.isospaspa
dc.publisherUniversidad de Córdobaspa
dc.relation.bitstreamhttps://revistamvz.unicordoba.edu.co/article/download/1076/pdf
dc.relation.citationeditionNúm. supl , Año 2017 : Revista MVZ Córdoba Volumen 22(Supl) Mayo 2017spa
dc.relation.citationendpage6074
dc.relation.citationissuesuplspa
dc.relation.citationstartpage6062
dc.relation.citationvolume22spa
dc.relation.ispartofjournalRevista MVZ Córdobaspa
dc.relation.referencesAronson AL. Pharmacotherapeutics of the newer tetracyclines. J Am Vet Med Assoc 1980; 176(10):1061–8.spa
dc.relation.referencesCunha, B.A. Sibley, C.M. Ristuccia AM. Doxyxycline. Ther Drug Monit 1982; 4(2):115. https://doi.org/10.1097/00007691-198206000-00001spa
dc.relation.referencesRiond JL, Vaden SL, Riviere JE. Comparative Pharmacokinetics of Doxycycline in Cats and Dogs. J Vet Pharmacol Ther 1990; 13(4):415–24. https://doi.org/10.1111/j.1365-2885.1990.tb00797.xspa
dc.relation.referencesBarza M, Brown RB, Shanks C, Gamble C, Weinstein L. Relation between lipophilicity and pharmacological behavior of minocycline, doxycycline, tetracycline, and oxytetracycline in dogs. Antimicrob Agents Chemother 1975; 8(6):713–20. https://doi.org/10.1128/AAC.8.6.713spa
dc.relation.referencesVillaescusa A, García-Sancho M, Rodríguez-Franco F, Tesouro MÁ, Sainz Á. Effects of doxycycline on haematology, blood chemistry and peripheral blood lymphocyte subsets of healthy dogs and dogs naturally infected with Ehrlichia canis. Vet J 2015; 204(3):263–8. https://doi.org/10.1016/j.tvjl.2015.03.031spa
dc.relation.referencesVon Wittenau, M.S. Yeary R. The excretion and distribution in body fluids of tetracyclines after intravenous administration to dogs. J Pharmacol Exp Ther 1963; 140(2):258–66.spa
dc.relation.referencesNeer TM, Breitschwerdt EB, Greene RT, Lappin MR. Consensus statement on ehrlichial disease of small animals from the infectious disease study group of the ACVIM. American College of Veterinary Internal Medicine. J Vet Intern Med 2002; 16(3):309–15. https://doi.org/10.1111/j.1939-1676.2002.tb02374.xspa
dc.relation.referencesSumano H, Ocampo L. Tetraciclinas. Farmacología veterinaria. México: MC Graw Hill; 2006.spa
dc.relation.referencesChambers HE. Inhibidores de la síntesis de proteína y otros antibacterianos. En: Laurence L. Brunton(Ed). Las Bases Farmacológicas de la Terapéutica. Undécima e. México: MC Graw Hill; 2008.spa
dc.relation.referencesVicente D, Pérez-Trallero E. Tetraciclinas, sulfamidas y metronidazol. Enferm Infecc Microbiol Clin 2010; 28(2):122–30. https://doi.org/10.1016/j.eimc.2009.10.002spa
dc.relation.referencesGutiérrez L, Velasco Z, Vázquez C, Vargas D, Sumano H. Pharmacokinetics of an injectable long-acting formulation of doxycycline hyclate in dogs. Acta Vet Scand 2012; 54(1):1. https://doi.org/10.1186/1751-0147-54-35spa
dc.relation.referencesDeck DH, Winston LG. Tetracyclines, Macrolides, Clindamycin, Chloramphenicol, Streptogramins, & Oxazolidinones. In: Katzung BG, Masters SB, Trevor AJ (editor). Basic & clinical pharmacology. Vol 12. 2012.spa
dc.relation.referencesSchulz BS, Hupfauer S, Ammer H, Sauter-Louis C, Hartmann K. Suspected side effects of doxycycline use in dogs - a retrospective study of 386 cases. Vet Rec 2011; 169(9):229. https://doi.org/10.1136/vr.d4344spa
dc.relation.referencesBartlett JG, Bustetter LA, Gorbach SL, Andrew B. Comparative Effect of Tetracycline and Doxycycline on the Occurrence of Resistant Escherichia coli in the Fecal Comparative Effect of Tetracycline and Doxycycline on the Occurrence of Resistant Escherichia coli in the Fecal Flora 1975; 7(1):55–7.spa
dc.relation.referencesLittle SE. Ehrlichiosis. In: Arthropod Borne Diseases. Springer International Publishing; 2017. https://doi.org/10.1007/978-3-319-13884-8_14spa
dc.relation.referencesPerez M, Bodor M, Zhang C, Xiong Q, Rikihisa Y. Human infection with Ehrlichia canis accompanied by clinical signs in Venezuela. Ann N Y Acad Sci 2006;1078:110–7. https://doi.org/10.1196/annals.1374.016spa
dc.relation.referencesBouza-mora L, Dolz G, Solórzano-morales A, Romero-zu JJ, Salazar-sánchez L, Labruna MB, et al. Novel genotype of Ehrlichia canis detected in samples of human blood bank donors in Costa Rica. Ticks Tick Borne Dis 2017; 8(1):36–40. https://doi.org/10.1016/j.ttbdis.2016.09.012spa
dc.relation.referencesLópez, J. Rivera, M. Concha, J. C. Gatica, S. Loeffeholz, M. Barriga O. Ehrlichiosis humana en Chile: evidencia serológica. Rev Med Chil 2003; 131(1):67–70. https://doi.org/10.4067/S0034-98872003000100010spa
dc.relation.referencesVargas-Hernandez, G., André, M. R., Cendales, D. M., Sousa, K. C. M. D., Gonçalves, L. R., Rondelli., Zacarías-Machado, R., Tinucci-Costa M. Molecular detection of Anaplasma species in dogs in Colombia. Braz J Vet Parasitol 2016; 25(4):459–64. https://doi.org/10.1590/s1984-29612016066spa
dc.relation.referencesNair ADS, Cheng C, Ganta CK, Sanderson MW, Alleman R, Munderloh UG, et al. Comparative Experimental Infection Study in Dogs with Ehrlichia canis, E . chaffeensis, Anaplasma platys and A . phagocytophilum. PLoS One 2016;11(2):1–21. https://doi.org/10.1371/journal.pone.0148239spa
dc.relation.referencesMiranda J, Mattar S. Molecular detection of Anaplasma sp. and ehrlichia sp. in ticks collected in domestical animals, Colombia. Trop Biomed 2015;32(4):726–35.spa
dc.relation.referencesWaner T, Harrus S, Jongejan F, Bark H, Keysary A. Cornelissen AWCA. Significance of serological testing for ehrlichial diseases in dogs with special emphasis on the diagnosis of canine monocytic ehrlichiosis caused by Ehrlichia canis. Vet Parasitol 2001; 95(1):1–15. https://doi.org/10.1016/S0304-4017(00)00407-6spa
dc.relation.referencesCasas EA. Seroprevalencia de la dirofilariosis y ehrlichiosis canina en tres distritos de Lima. Rev Inv Vet Peru 2003;14(1):43–8.spa
dc.relation.referencesSwann JW, Woods K, Wu Y, Glanemann B, Garden OA. Characterisation of the Immunophenotype of Dogs with Primary Immune-Mediated Haemolytic Anaemia. PLoS One 2016; 11(2):1-18. https://doi.org/10.1371/journal.pone.0168296spa
dc.relation.referencesMccullough S. Immune-mediated hemolytic anemia : understanding the nemesis. Vet Clin North Am Small Anim Pr 2003; 33:1295–315. https://doi.org/10.1016/j.cvsm.2003.08.003spa
dc.relation.referencesGe, Y., Yin, H., Rikihisa, Y., Pan, W., & Yin H. Molecular Detection of Tick-Borne Rickettsiales in Goats and Sheep from Southeastern China. Vector-Borne Zoonotic Dis. 2016; 16(5):309–16. https://doi.org/10.1089/vbz.2015.1884spa
dc.relation.referencesKarnezi D, Ceron JJ, Theodorou K, Leontides L, Siarkou VI, Martinez S, et al. Acute phase protein and antioxidant responses in dogs with experimental acute monocytic ehrlichiosis treated with rifampicin. Vet Microbiol 2016; 184:59–63. https://doi.org/10.1016/j.vetmic.2016.01.007spa
dc.relation.referencesLittle SE. Ehrlichiosis and Anaplasmosis in Dogs and Cats. Vet Clin North Am - Small Anim Pract 2010; 40(6):1121–40. https://doi.org/10.1016/j.cvsm.2010.07.004spa
dc.relation.referencesRikihisa Y. Anaplasma phagocytophilum and Ehrlichia chaffeensis : subversive manipulators of host cells. Nat Publ Gr 2010; 8(5):328–39. https://doi.org/10.1038/nrmicro2318spa
dc.relation.referencesKucuk A, Kabadere S, Tosun M, Koken T, Kinaci MK, Isikli B, et al. Protective effects of doxycycline in ischemia/reperfusion injury on kidney. J Physiol Biochem 2009; 65(2):183–91. https://doi.org/10.1007/BF03179069spa
dc.relation.referencesGabler, W.L. Creamer HR. Suppression of human neutrophil functions by tetracyclines. J Periodontal Res 1991; 26(1):52–8. https://doi.org/10.1111/j.1600-0765.1991.tb01626.xspa
dc.relation.referencesGriffin MO, Fricovsky E, Ceballos G, Villarreal F. Tetracyclines : a pleitropic family of compounds with promising therapeutic properties. Review of the literature. Am J Physiol Cell Physiol 2010; 299(3):C539-48. https://doi.org/10.1152/ajpcell.00047.2010spa
dc.relation.referencesFrank JR, Breitschwerdt EB. A Retrospective Study of Ehrlichiosis in 62 Dogs from North Carolina and Virginia. J Vet Intern Med 1999; 13(3):194-201. https://doi.org/10.1111/j.1939-1676.1999.tb02178.xspa
dc.relation.referencesDe Castro MB, Machado RZ, De Aquino LPCT, Alessi AC, Costa MT. Experimental acute canine monocytic ehrlichiosis: Clinicopathological and immunopathological findings. Vet Parasitol 2004; 119(1):73–86. https://doi.org/10.1016/j.vetpar.2003.10.012spa
dc.relation.referencesIsmail N, Crossley EC, Stevenson HL, Walker DH. Relative Importance of T-Cell Subsets in Monocytotropic Ehrlichiosis : a Novel Effector Mechanism Involved in Ehrlichia -Induced Immunopathology in Murine Ehrlichiosis. Infect Immun 2007; 75(9):4608-4620. https://doi.org/10.1128/IAI.00198-07spa
dc.relation.referencesWinslow GM, Yager E, Shilo K, Volk E, Reilly A, Chu FK. Antibody-Mediated Elimination of the Obligate Intracellular Bacterial Pathogen Ehrlichia chaffeensis during Active Infection. Infect Immun 2000; 68(4):2187-2195. https://doi.org/10.1128/IAI.68.4.2187-2195.2000spa
dc.relation.referencesHarrus S, Waner T, Friedmann-morvinski D. Down-regulation of MHC class II receptors of DH82 cells, following infection with Ehrlichia canis. Vet Immunol Immunopathol 2003; 96(3-4):239-43. https://doi.org/10.1016/j.vetimm.2003.08.005spa
dc.relation.referencesWilson RC, Kemp DT, Kitzman J V., Goetsch DD. Pharmacokinetics of doxycycline in dogs. Can J Vet Res 1988; 52(1):12–4.spa
dc.relation.referencesMaurin M, Bakken JS, Dumler JS. Antibiotic susceptibilities of Anaplasma (Ehrlichia) phagocytophilum strains from various geographic areas in the United States. Antimicrob Agents Chemother 2003; 47(1):413–5. https://doi.org/10.1128/AAC.47.1.413-415.2003spa
dc.relation.referencesCollins, S.P. Labelle, A.L. Dirikolu, L. Li, Z. Mitchell, M.A. Hamor RE. Tear film concentrations of doxycycline following oral administration in ophthalmologically normal dogs. J Am Vet Med Assoc 2016; 249(5):508–14. https://doi.org/10.2460/javma.249.5.508spa
dc.relation.referencesArciniegas-Ruiz SM, Gutiérrez-Olvera L, Bernad-Bernad MJ, Caballero-Chacón SDC, Vargas-Estrada D. Comparative pharmacokinetics of a new oral long-acting formulation of doxycycline hyclate: A canine clinical trial. Eur J Pharm Sci 2015; 80:9–15. https://doi.org/10.1016/j.ejps.2015.09.012spa
dc.relation.referencesVicente D, Pérez-Trallero E. Tetraciclinas, sulfamidas y metronidazol. Enferm Infecc Microbiol Clin 2010; 28(2):122–30. https://doi.org/10.1016/j.eimc.2009.10.002spa
dc.relation.referencesArmijo JA. Absorción, distribución y eliminación de los fármacos. In: editor. Farmacología humana. Barcelona: Masson S.A: 1997.spa
dc.relation.referencesPerez-Trallero E, Iglesias L. Tetraciclinas, sulfamidas y metronidazol. Enferm Infecc Microbiol Clin 2010; 28(2):122–30. https://doi.org/10.1016/j.eimc.2009.10.002spa
dc.relation.referencesRiond J, Riviere JE. Doxycycline binding to plasma albumin of several species. J Vet Pharmacol Ther 1989; 12(3):253-260. https://doi.org/10.1111/j.1365-2885.1989.tb00668.xspa
dc.relation.referencesBidgood TL, Papich MG. Comparison of plasma and interstitial fluid concentrations of doxycycline and meropenem following constant rate intravenous infusion in dogs. Am J Vet Res 2003; 64(8):1040–6. https://doi.org/10.2460/ajvr.2003.64.1040spa
dc.relation.referencesPassalidou, P. Giudicelli, H. Moreigne, M. Khalfi A. Un cas d'ulcère œsophagien secondaire à la prise de doxycycline. Arch Pédiatrie 2006; 13(1):90–1. https://doi.org/10.1016/j.arcped.2005.10.014spa
dc.relation.referencesMichel, G. Mosser, J. Fauran AU. Serum kinetics of doxycycline polyphosphate in dogs. Eur J Drug Metab Pharmacokinet 1979; 1:43–48. https://doi.org/10.1007/BF03189398spa
dc.relation.referencesIqbal ZRY. Reisolation of Ehrlichia canis from Blood and Tissues of Dogs after Doxycycline Treatment. J Clin Microbiol 1994; 32(7):1644–9.spa
dc.relation.referencesBreitschwerdt EB, Hegarty BC, Hancock SI, Carolina N, Carolina N. Doxycycline Hyclate Treatment of Experimental Canine Ehrlichiosis Followed by Challenge Inoculation with Two Ehrlichia canis Strains. Antimicrob Agents Chemother 1998; 42(2): 362–368.spa
dc.relation.referencesMcClure JC, Crothers ML, Schaefer JJ, Stanley PD, Needham GR, Ewing SA, et al. Efficacy of a doxycycline treatment regimen initiated during three different phases of experimental ehrlichiosis. Antimicrob Agents Chemother 2010; 54(12):5012–20. https://doi.org/10.1128/AAC.01622-09spa
dc.relation.referencesChiers K, Weyens P, Deprez P, Heerden M van, Meulemans G, Baert K, et al. Lingual and pharyngeal paralysis due to acute doxycycline intoxication in veal calves. Vet Rec 2004;155(1):25–6. https://doi.org/10.1136/vr.155.1.25spa
dc.relation.referencesRiond J, Riviere JE, Duckettt WM, Atkins CE. Cardiovascular effects and fatalities associated with intravenous administration of doxycycline to horses and ponies. Equine Vet J 1992;24:41–5. https://doi.org/10.1111/j.2042-3306.1992.tb02777.xspa
dc.relation.referencesSchölkens, B. Gerhards, H. Lindner E. Circulatory effects of intravenously administered rolitetracycline and other tetracyclines in animal experiments. Arzneimittelforschung 1971; 24(3):312–7.spa
dc.relation.referencesBrouqui P, Raoult D. In vitro susceptibility of Ehrlichia sennetsu to antibiotics. Antimicrob Agents Chemother 1990; 34(8):1593–6. https://doi.org/10.1128/AAC.34.8.1593spa
dc.relation.referencesBranger S, Rolain JM, Raoult D. Evaluation of antibiotic susceptibilities of Ehrlichia canis, Ehrlichia chaffeensis, and Anaplasma phagocytophilum by real-time PCR. Antimicrob Agents Chemother 2004; 48(12):4822–8. https://doi.org/10.1128/AAC.48.12.4822-4828.2004spa
dc.relation.referencesDavoust B, Keundjian A, Rous V, Maurizi L, Parzy D. Validation of chemoprevention of canine monocytic ehrlichiosis with doxycycline. Vet Microbiol 2005;107(3–4):279–83. https://doi.org/10.1016/j.vetmic.2005.02.002spa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.coarhttp://purl.org/coar/access_right/c_abf2spa
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0/spa
dc.sourcehttps://revistamvz.unicordoba.edu.co/article/view/1076spa
dc.subjectBlood chemistryeng
dc.subjectEhrlichia caniseng
dc.subjecthematologyeng
dc.subjectpharmacokineticseng
dc.subjecttetracyclineeng
dc.subjectEhrlichia canisspa
dc.subjectfarmacocinéticaspa
dc.subjecthematologíaspa
dc.subjectquímica sanguíneaspa
dc.subjecttetraciclinaspa
dc.titleFarmacocinética y efectos adversos de la doxiciclina en el tratamiento de la Ehrlichiosis: fundamentos teóricos para ensayos clínicos en caninosspa
dc.title.translatedPharmacokinetics and adverse effects of doxycycline in the treatment of Ehrlichiosis: theoretical foundations for clinical trials in canineseng
dc.typeArtículo de revistaspa
dc.typeJournal articleeng
dc.type.coarhttp://purl.org/coar/resource_type/c_6501spa
dc.type.coarhttp://purl.org/coar/resource_type/c_6501spa
dc.type.coarversionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa
dc.type.contentTextspa
dc.type.driverinfo:eu-repo/semantics/articlespa
dc.type.redcolhttp://purl.org/redcol/resource_type/ARTREFspa
dc.type.versioninfo:eu-repo/semantics/publishedVersionspa
dspace.entity.typePublication
Archivos
Colecciones