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Baseline in vivo, ex vivo and molecular responses of Plasmodium falciparum to artemether and lumefantrine in three endemic zones for malaria in Colombia

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dc.contributor.authorAPONTE, SAMANDAspa
dc.contributor.authorGUERRA, ÁNGELAspa
dc.contributor.authorÁLVAREZ, CATALINAspa
dc.contributor.authorDURLEY, SINDYspa
dc.contributor.authorRESTREPO, CÉSARspa
dc.contributor.authorGONZALEZ, CAMILAspa
dc.contributor.authorYASNOT, MARÍAspa
dc.contributor.authorKNUDSON, ANGÉLICAspa
dc.date.accessioned2018-03-05T21:01:11Zspa
dc.date.available2018-03-05T21:01:11Zspa
dc.date.issued2017-04-13spa
dc.description.abstractBackground: Colombia began using artemisinin-based combination therapies for the treatment of uncomplicated Plasmodium falciparum malaria in 2006. It is necessary to implement resistance surveillance to antimalarial drugs in order to promptly detect changes in parasite susceptibility. The aim of this study was to establish a susceptibility baseline of P. falciparum to artemether-lumefantrine using three monitoring tools. Methods: Patients with uncomplicated malaria treated with artemether-lumefantrine underwent clinical and parasitological follow-up over 28 days. Ex vivo test was performed using the microtest technique for chloroquine, arthemeter, dihydroartemisinin and lumefantrine. Pfmdr1 copy number and polymorphisms in Pfk13, Pfatp6, Pfcrt and Pfmdr1 genes were analyzed. Results: From a total of 150 screened patients, 49 completed follow-up for 28 days. All treated patients had adequate clinical and parasitological responses. Parasitic clearance showed a drastic reduction of parasite biomass at 24 hours and complete elimination at 48 hours. One hundred eleven isolates were processed, all exhibited high susceptibility to artemisinins and a slight decrease in susceptibility to lumefantrine. No genetic polymorphisms associated with resistance to artemisinin were found. Conclusion: This study generated a susceptibility baseline in response to therapy with Coartem (artemetherlumefantrine) with numerical reference values, which will allow data comparison with future studies to systematically monitor changes in the parasite and to provide an early alert to the health authorities.spa
dc.identifier.citationAponte, S., Guerra, Á. P., Álvarez-Larrotta, C., Bernal, S. D., Restrepo, C., González, C., ... & Knudson-Ospina, A. (2017). Baseline in vivo, ex vivo and molecular responses of Plasmodium falciparum to artemether and lumefantrine in three endemic zones for malaria in Colombia. Transactions of The Royal Society of Tropical Medicine and Hygiene, 111(2), 71-80.spa
dc.identifier.other0035-9203spa
dc.identifier.urihttps://repositorio.unicordoba.edu.co/handle/ucordoba/622spa
dc.language.isoengspa
dc.relation.ispartofseriesDOI;10.1093/trstmh/trx021spa
dc.rightsCopyright Universidad de Córdoba, 2020spa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.creativecommonsAtribución 4.0 Internacional (CC BY 4.0)spa
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/spa
dc.subjectArtemisinin-based combination therapies (ACT), Colombia, Plasmodium falciparum, Polymorphisms, Resistance surveillance, Therapeutic efficacy studies (TES)spa
dc.titleBaseline in vivo, ex vivo and molecular responses of Plasmodium falciparum to artemether and lumefantrine in three endemic zones for malaria in Colombiaspa
dc.typeArtículo de revistaspa
dc.type.coarhttp://purl.org/coar/resource_type/c_6501spa
dc.type.contentTextspa
dc.type.driverinfo:eu-repo/semantics/articlespa
dc.type.redcolhttps://purl.org/redcol/resource_type/ARTspa
dc.type.versioninfo:eu-repo/semantics/publishedVersionspa
dspace.entity.typePublication
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2spa
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa
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