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Dirofilaria immitis en perros domésticos de la ciudad de Barranquilla: aspectos epidemiológicos y clínicos

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dc.contributor.advisorOviedo Socarrás, Teresa
dc.contributor.advisorOviedo, Misael
dc.contributor.advisorBadillo Viloria, María Auxiliadora
dc.contributor.authorLavalle Galvis, Rodrigo José de
dc.contributor.juryTique Salleg, Vaneza Paulin
dc.contributor.juryFlórez Muños, Ángel Alberto
dc.date.accessioned2024-01-23T20:54:58Z
dc.date.available2024-01-23T20:54:58Z
dc.date.issued2024-01-03
dc.description.abstractEn la actualidad, las enfermedades infecciosas y enfermedades zoonóticas son en su mayor proporción el resultado o causa de enfermedades transmitidas por vectores. La dirofilariasis es una enfermedad zoonótica causada por el nematodo Dirofilaria immitis, el cual afecta perros, gatos y humanos que habitan zonas tropicales y templadas a nivel mundial con condiciones climáticas de altas temperaturas y humedad. La dirofilariasis canina está ampliamente distribuida a nivel mundial y es favorecida por factores ambientales como temperatura y humedad, siendo predominante en regiones de climas cálidos, tropicales y subtropicales (Simon et al. 2012). Se compararon diferentes métodos de diagnóstico para la dirofilariosis en caninos infectados naturalmente con D. immits , 59 perros fueron positivos por PCR, 59 fueron positivos por test de Knott modificado (TKM), 80 perros fueron positivos a TKM-PCR, 96 fueron positivos a la prueba de antígenos sin tratamiento térmico (TIM) y 104 perros fueron positivos con la prueba de antígenos con tratamiento térmico (TIM-TT). La sensibilidad y especificidad de TKM fue 53,0% y 92,0%, respectivamente; para PCR fue 45,0% y 84,0%, para TIM fue 92,0% y 99,0%, y para TIM-TT 95.2% y 99% respectivamente. El índice de Youden determinó el mejor punto de corte entre sensibilidad y especificidad para TIM-TT (0,94); seguido de TKM (0,55) y PCR (0,34). Kappa de Cohen estimó bajo desempeño para PCR, moderado desempeños para TKM y buen desempeño para TIM. La prevalencia real de D. immitis en los perros fue de 55,8%.spa
dc.description.abstractAt present, infectious diseases and zoonotic diseases are mostly the result or cause of vector-borne diseases. Heartworm is a zoonotic disease caused by the Dirofilaria immitis nematode, which affects dogs, cats and humans that inhabit tropical and temperate areas worldwide with climatic conditions of high temperatures and humidity. Canine heartworm is widely distributed worldwide and is favored by environmental factors such as temperature and humidity, being predominant in regions with hot, tropical and subtropical climates (Simon et al. 2012). Different diagnostic methods for heartworm disease were compared in canines naturally infected with D. immits, 59 dogs were positive by PCR, 59 were positive by modified Knott test (TKM), 80 dogs were positive by TKM-PCR, 96 were positive by the antigen test without heat treatment (TIM) and 104 dogs were positive with the test heat treated antigens (TIM-TT). The sensitivity and specificity of TKM were 53.0% and 92.0%, respectively; for PCR it was 45.0% and 84.0%, for TIM it was 92.0% and 99.0% and for TIM-TT 95.2% y 99%, respectively. The Youden index determined the best cut-off point between sensitivity and specificity for TIM-TT (0.94); followed by TKM (0.55) and PCR (0.34). Cohen's Kappa estimated low performance for CRP, moderate performance for TKM and good performance for TIM. The actual prevalence of D. immitis in dogs was 55.8.eng
dc.description.degreelevelMaestría
dc.description.degreenameMagíster en Ciencias Veterinarias del Trópico
dc.description.modalityTrabajos de Investigación y/o Extensión
dc.description.tableofcontentsRESUMEN GENERAL....................8
dc.description.tableofcontentsABSTRACT.....................10
dc.description.tableofcontentsPalabras clave....................11
dc.description.tableofcontentsKey words..................11
dc.description.tableofcontentsINTRODUCCIÓN..................12
dc.description.tableofcontents1. OBJETIVOS..................15
dc.description.tableofcontents1.1. Objetivo General:..................15
dc.description.tableofcontents1.2. Objetivos específicos:..................15
dc.description.tableofcontents2. MARCO TEÓRICO..................16
dc.description.tableofcontents2.1. Descripción y taxonomía..................16
dc.description.tableofcontents2.2. Epidemiología..................16
dc.description.tableofcontents2.3. Ciclo de biológico..................20
dc.description.tableofcontents2.4. Patofisiología..................23
dc.description.tableofcontents2.5. Presentación clínica..................26
dc.description.tableofcontents2.6. Diagnóstico..................27
dc.description.tableofcontents2.6.1.Diagnóstico microscópico: Knott modificado..................28
dc.description.tableofcontents2.6.2.Diagnóstico serológico..................29
dc.description.tableofcontents2.6.3.Diagnóstico molecular..................30
dc.description.tableofcontents2.6.4.Diagnóstico paraclínico..................1
dc.description.tableofcontents2.6.5.Diagnóstico clínico..................31
dc.description.tableofcontents3.CAPÍTULO 2..................33
dc.description.tableofcontentsComparación de 3 métodos diagnósticos para la detección de infección por Dirofilaria immitis en caninos...................33
dc.description.tableofcontentsResumen..................33
dc.description.tableofcontentsAbstract..................34
dc.description.tableofcontentsPalabras claves:..................35
dc.description.tableofcontentsKey words..................35
dc.description.tableofcontentsIntroducción..................35
dc.description.tableofcontentsMateriales y métodos..................37
dc.description.tableofcontentsResultados..................41
dc.description.tableofcontentsDiscusión..................43
dc.description.tableofcontentsConclusiones..................46
dc.description.tableofcontentsReferencias..................47
dc.description.tableofcontents4.CAPÍTULO 3..................52
dc.description.tableofcontentsDistribución de Dirofilaria immitis en perros en el área metropolitana del Caribe Colombiano y su correlación clínica y epidemiológica...................52
dc.description.tableofcontentsResumen..................52
dc.description.tableofcontentsPalabras claves..................53
dc.description.tableofcontentsIntroducción..................53
dc.description.tableofcontentsMateriales y métodos...................55
dc.description.tableofcontentsDiscusión...................63
dc.description.tableofcontentsConclusiones...................66
dc.description.tableofcontentsReferencias...................68
dc.description.tableofcontentsCONCLUSIONES GENERALES..................74
dc.description.tableofcontentsRECOMENDACIONES GENERALES..................75
dc.description.tableofcontents5.REFERENCIAS..................76
dc.format.mimetypeapplication/pdf
dc.identifier.instnameUniversidad de Córdoba
dc.identifier.reponameRepositorio Universidad de Córdoba
dc.identifier.repourlhttps://repositorio.unicordoba.edu.co
dc.identifier.urihttps://repositorio.unicordoba.edu.co/handle/ucordoba/8076
dc.language.isospa
dc.publisherUniversidad de Córdoba
dc.publisher.facultyFacultad de Medicina Veterinaria y Zootecnia
dc.publisher.placeBerastegui, Córdoba, Colombia
dc.publisher.programMaestría en Ciencias Veterinarias del Trópico
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dc.rightsCopyright Universidad de Córdoba, 2024
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.coarhttp://purl.org/coar/access_right/c_abf2
dc.rights.licenseAtribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourcehttps://repositorio.unicordoba.edu.co
dc.subject.keywordsHeartwormeng
dc.subject.keywordsPublic healtheng
dc.subject.keywordsZoonosiseng
dc.subject.keywordsMolecular diagnosiseng
dc.subject.keywordsMosquitoeng
dc.subject.proposalDirofilariosisspa
dc.subject.proposalSalud públicaspa
dc.subject.proposalZoonosisspa
dc.subject.proposalDiagnóstico molecularspa
dc.subject.proposalMosquitospa
dc.titleDirofilaria immitis en perros domésticos de la ciudad de Barranquilla: aspectos epidemiológicos y clínicos
dc.typeTrabajo de grado - Maestría
dc.type.coarhttp://purl.org/coar/resource_type/c_bdcc
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.contentText
dc.type.driverinfo:eu-repo/semantics/masterThesis
dc.type.redcolhttp://purl.org/redcol/resource_type/TM
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
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