Health care is one of the conditions that every human being, regardless of race, nationality, or social position seeks to obtain, however, in such care a particular situation is observed, such as services to patients with high-cost diseases. Through this monograph, a descriptive analysis and review of documents referring to catastrophic and high-cost diseases or pathologies that imply a greater expense for the general health system and for the person suffering from it is carried out. A bibliographic search and consultations were made to obtain publications and other important documents, using the following tools and sources, scielo.org.co; Academic google; University of Córdoba database (eLibro.net, vlex, proquest). For this work, it was taken into account that the state of health is the factor that most implies the variations in it, above other variables such as age, sex and socioeconomic conditions, the different normative documents related to pathologies or diseases will be sought high cost. The bibliographic search focused on obtaining material that helped to identify how the most representative high-cost diseases are documented in terms of regulations (Laws, Decrees, Resolutions). It is worth mentioning that, despite the fact that each disease has regulations that guarantee comprehensive care, it is observed that the lack of clarity limits patients to accessing the treatments at the indicated times, leading some patients to wait for treatment for several months inclusive; This situation leads one to wonder what the standard says in this regard and how it should be done to put it into operation. With this analysis, it was intended to know what was established through the Social Security System in Health on concepts of catastrophic diseases or high cost, as well as the behavior of the regulations in the most relevant high-cost diseases. On the other hand, the aim was to describe the regulations that regulate the care of patients with catastrophic or high-cost illnesses in Colombia. From every conception, there are still many things that it considers in relation to standardizing services and technologies in the care of high-cost diseases, especially making it more affordable to people who suffer from it, this is especially true in: user to the IPS, delivery with opportunity of medicine or 8 supplies necessary to cope with their health condition, generation of authorizations for consultations or surgical procedures with the appropriate opportunity and relevance. On the other hand, it is evident, the frequent adjustment that the state through the Ministry of Health and Social Protection has made to the regulations of high cost and catastrophic diseases, showing among some aspects the following: Resolutions that indicate the entry of services, procedures and pathologies to the list of high cost diseases. The creation of a high-cost account in order to ensure the resources that are destined to the care of patients who have this pathology or are qualified by them. Support institutions that are dedicated to the care of patients with high-cost pathologies.