In Colombia, patient safety is one of the five characteristics that the Ministry of Health and Social Protection (MINPRO) incorporates in the Mandatory System for the Quality Assurance of Health Care (SOGCS), which seeks to reduce and eliminating the risk of suffering unnecessary harm caused by health care and / or system failures and mitigating their consequences (Ministry of Health and Social Protection [MINPRO], 2006). However, today receiving health care involves potential risks, even though millions of people are cared for safely every day. Therefore, when an IPS implements safe practices, it promotes causal analysis that allows identifying the reasons for which the adverse event, incident and / or death occurred, so that the system can be continuously improved; define measurement methods that determine and inform strategies or actions that improve the patient care system and reduce the risk of recurrence. Likewise, the damages or deaths in the patient are born as a result of medical errors, which also imply failures in the health systems. These adverse events generate the creation of standards that help minimize errors and their consequences in health systems and therefore in patients. Consequently, the different IPS must comply with good practices for patient safety, which allows minimizing failures in the security levels in the provision of the service and innovative strategies are carried out that protect the patient from avoidable risks derived from health care. For this reason, and in order to continuously verify good practices for patient safety and minimize the occurrence of adverse events, the present research work was drawn up, which has as its main objective to evaluate compliance with good practices for patient safety at the ESE Camú Santa Teresita de Lorica - Córdoba. In addition, recommendations will be made so that the ESE remains focused on continuous improvement, through the implementation of different strategies that help reduce the occurrence of adverse events and ensure the health of people, thus minimizing the risk of suffering adverse events, or mitigating its consequences. This research work comprises a cross-sectional descriptive study, with a quantitative approach to compliance with good practices for patient safety in the ESE Camu Santa Teresita - Lorica, 2020. Its scope ranges from carrying out a diagnostic process that allows knowing the situation current topic of safe care and evaluate it through a checklist of "Good practices for patient safety in health care", of the Ministry of Health and Social Protection, as applicable to the complexity of the ESE Camu Santa Teresita; until results are obtained that guide the prioritization of specific health care processes according to the opportunity for improvement that they show. The results obtained show that the tasks carried out by health personnel are not focused on providing safe care to patients, the issue of the perception of the safety culture is evidenced with little encouraging results in each of the components of the safety of the patient, since the ESE complies in 87% with the guide of good practices for patient safety. In addition, the practice with the lowest compliance is to prevent pressure ulcers since it only complies in 63.6%, indicating that its quality level is poor. Therefore, senior management must focus sufficiently on the implementation and development of patient safety, providing equipment and supplies to the staff and the ESE in general, implement protocols and evidence their progress; further train healthcare personnel, and that if there is no greater control of it, it can cause a risk in health care.