Díaz Pongutá, BasilioHernández Pérez, Lina Marcela2021-09-282021-09-282021-09-25https://repositorio.unicordoba.edu.co/handle/ucordoba/4579Spectroscopy is one of the tools most used in the analysis of different environmental sources, it allows to know the composition of organic and inorganic species, allowing studies in the area of health, detection of genotoxic substances, drug development, responses to treatment, among others. For decades molecular spectroscopy has made it possible to carry out quantitative and qualitative analyzes, by means of methods that reveal the properties, composition of materials, samples and simple or complex substances (molecules, ions, groups or metabolites), through the emission of radiation that said samples absorb, getting to know the composition of the matter characterizing it from spectra, images and numerical results. The following work aimed to collect information associated with molecular spectroscopy useful in determining biomarkers of exposure and susceptibility, thus revealing useful information for future research in Colombia. For this, a bibliographic compilation was carried out through the use of databases such as: Science Direct, Brazilian Journal of Pharmaceutical Sciences, Latin American Chemistry Journal, Medicine Journal, Sanitary Gazette Journal, among others. As a result of this research, bases were obtained for the orientation of research projects, analyzes, studies, types of biomarkers or alterations that may present in certain environmental spheres, health, drugs when exposed to external or toxic substances. The information to be reported will be from a reliable and updated source to obtain as a result a truthful study with current antecedents, the information to be shown was collected and verified through the use of software, which guarantees the veracity of said information, a description will be made, obtaining clear chapters with accurate information that respond to each specific objective raised in this final monograph report.RESUMEN 9INTRODUCCIÓN 11OBJETIVOS 13OBJETIVO GENERAL 13OBJETIVOS ESPECÍFICOS 13MATERIALES Y METODOS 14DESARROLLO DEL TEMA 15CAPITULO I: GENERALIDADES DE LOS BIOMARCADORES DE SUSCEPTIBILIDAD 15PRINCIPIOS DE LA MEDICIÓN 15Marcador biológico de exposición 15Biomarcador de susceptibilidad. 16Requerimientos que deberá cumplir un biomarcador ideal. 19Validación de biomarcadores. 19IDENTIFICACIÓN Y VALIDACIÓN DE NUEVOS MARCADORES BIOLÓGICOS. 20Espectrometría de masas 22Fotometría 24Potenciometría 25Pretratamiento 26Tratamiento fuera de línea 26Tratamiento en línea 26CAPITULO II: ESPECTROSCOPÍA MOLECULAR EMPLEADA EN ESTUDIOS DE SISTEMAS BIOLÓGICOS. 27Microespectroscopía de infrarrojo con Transformada de Fourier (FTIRM) en el estudio de sistemas biológicos. 27TÉCNICA DE MICROESPECTROSCOPÍA DE INFRARROJO CON TRANSFORMADA DE FOURIER (FITRM) 30Biomarcadores en toxicología humana 35Control biológico. 37Biomarcadores en monitoreo de exposición a metales pesados en metalurgia. 38Biomarcadores en carcinogénesis 40Combinando enfoques metodológicos. 41Síntesis de perilenodiaminas con aplicación como biomarcadores fluorescentes. 42ANALISIS Y DISCUSIONES 43CONCLUSIONES 46REFERENCIAS 48application/pdfspaCopyright Universidad de Córdoba, 2021Trabajo de grado - Pregradoinfo:eu-repo/semantics/openAccessAtribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)IndicadorSustancias toxicasEsferas ambientalesSustancias externasDetecciónIndicatorToxic substancesEnvironmental spheresExternal substancesDetection