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VILLEGAS, ROSSANA FRANCO, CATALINA RENDÓN, JAVIER TORRES, JOSÉ JARAMILLO, PATRICIA 2018-03-05T20:43:56Z 2018-03-05T20:43:56Z 2016-05-04 Villegas GR, Franco AC, Rendón HJ, Torres HJD, Jaramillo APE. Frequency of monoclonal B-cell lymphocytosis in relatives of patients with chronic lymphocytic leukemia. Colomb Med (Cali). 2016; 47(2): 81-6. 1657-9534 https://repositorio.unicordoba.edu.co/handle/ucordoba/618 Introduction: monoclonal B-cell lymphocytosis is a symptom free condition characterized by the circulation of small clonal population of B lymphocytes in peripheral blood (less than 5x109/L) expressing an immunophenotype similar to chronic lymphocytic leukemia. Different studies based on big hospital series have manifested a higher risk in subjects with monoclonal B-cell lymphocytosis to progress to a chronic lymphocytic leukemia. The behavior of this hematologic entity is unknown therefore its frequency in sporadic chronic lymphocytic leukemia patient relatives was determined. Methods: transversal descriptive study, 8 color flow cytometry was performed using two of the tubes of the Euro Flow recommended panel, with modifications, for the diagnose of chronic lymphoproliferative disorders of B lymphocytes; besides, a fluorescence in situ hybridization was performed. univariate and bivariate analyses of the information were performed. Results: monoclonal B-cell lymphocytosis frequency found in 51 analyzed relatives was 2%, it was a female participant, 59 years old, with a total leukocyte count of 7.7x109/L and a B lymphocyte count of 0.124x109/L; from these, 0.04x109/L were clonal cells with restrictions of the kappa light chain. Rearrangements of the IGH gene (14q32) were found. Conclusion: monoclonal B-cell lymphocytosis was detected in one relative of a patient with sporadic chronic lymphocytic leukemia in a frequency similar to the one reported in general population. spa Copyright Universidad de Córdoba, 2016 https://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess Atribución 4.0 Internacional (CC BY 4.0) Monoclonal B-cell lymphocytosis, chronic lymphocytic leukemia, B cells, flow cytometry Frequency of monoclonal B-cell lymphocytosis in relatives of patients with chronic lymphocytic leukemia Frecuencia de linfocitosis monoclonal de células B en familiares de pacientes con leucemia linfoide crónica Artículo de revista info:eu-repo/semantics/article http://purl.org/coar/resource_type/c_6501 info:eu-repo/semantics/publishedVersion Text https://purl.org/redcol/resource_type/ART http://purl.org/coar/access_right/c_abf2 http://purl.org/coar/version/c_970fb48d4fbd8a85 Publicationopen.access