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dc.contributor.authorVILLEGAS, ROSSANA
dc.contributor.authorFRANCO, CATALINA
dc.contributor.authorRENDÓN, JAVIER
dc.contributor.authorTORRES, JOSÉ
dc.contributor.authorJARAMILLO, PATRICIA
dc.date.accessioned2018-03-05T20:43:56Z
dc.date.available2018-03-05T20:43:56Z
dc.date.issued2016-05-04
dc.identifier.citationVillegas GR, Franco AC, Rendón HJ, Torres HJD, Jaramillo APE. Frequency of monoclonal B-cell lymphocytosis in relatives of patients with chronic lymphocytic leukemia. Colomb Med (Cali). 2016; 47(2): 81-6.en_US
dc.identifier.issn1657-9534
dc.identifier.urihttp://hdl.handle.net/123456789/618
dc.description.abstractIntroduction: monoclonal B-cell lymphocytosis is a symptom free condition characterized by the circulation of small clonal population of B lymphocytes in peripheral blood (less than 5x109/L) expressing an immunophenotype similar to chronic lymphocytic leukemia. Different studies based on big hospital series have manifested a higher risk in subjects with monoclonal B-cell lymphocytosis to progress to a chronic lymphocytic leukemia. The behavior of this hematologic entity is unknown therefore its frequency in sporadic chronic lymphocytic leukemia patient relatives was determined. Methods: transversal descriptive study, 8 color flow cytometry was performed using two of the tubes of the Euro Flow recommended panel, with modifications, for the diagnose of chronic lymphoproliferative disorders of B lymphocytes; besides, a fluorescence in situ hybridization was performed. univariate and bivariate analyses of the information were performed. Results: monoclonal B-cell lymphocytosis frequency found in 51 analyzed relatives was 2%, it was a female participant, 59 years old, with a total leukocyte count of 7.7x109/L and a B lymphocyte count of 0.124x109/L; from these, 0.04x109/L were clonal cells with restrictions of the kappa light chain. Rearrangements of the IGH gene (14q32) were found. Conclusion: monoclonal B-cell lymphocytosis was detected in one relative of a patient with sporadic chronic lymphocytic leukemia in a frequency similar to the one reported in general population.en_US
dc.language.isoesen_US
dc.subjectMonoclonal B-cell lymphocytosis, chronic lymphocytic leukemia, B cells, flow cytometryen_US
dc.titleFrequency of monoclonal B-cell lymphocytosis in relatives of patients with chronic lymphocytic leukemiaen_US
dc.title.alternativeFrecuencia de linfocitosis monoclonal de células B en familiares de pacientes con leucemia linfoide crónicaen_US
dc.typeArticleen_US


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